Connective Tissue‐Associated Proteins in Crevicular Fluid:

Bowers, Mary R.; Fisher, Larry W.; Termine, John D.; Somerman, Martha J.

doi:10.1902/jop.1989.60.8.448

Cited by 36 publications

(28 citation statements)

References 20 publications

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“…In an alternative approach, Bowers et al (1989) used antisera raised toward the N-propeptide obtained from the a 1 -chains of type I collagen. Dot-blot ELISA assays indicated the presence of N-propeptide in all GCF samples, with higher amounts evident in samples from moderate to severe periodontitis by comparison with gingivitis-only sites.…”

Section: Collagensmentioning

confidence: 99%

“…The primary report is that of Bowers et al (1989) in which osteonectin, a phosphorylated glycoprotein, and bone sialoglycoproteins I and II were studied by use of specific antisera against GCF collected from patients showing increasing periodontal disease. Neither sialoglycoprotein I nor II was identified in GCF, although osteonectin was present in most samples and increased with more severe periodontal disease.…”

Section: Other Connective Tissue Proteinsmentioning

confidence: 99%

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Gingival Crevicular Fluid: Biomarkers of Periodontal Tissue Activity

Embery¹,

Waddington²

1994

Adv Dent Res.

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The lack of precise clinical criteria for assessment of periodontal disease has led to a search for alternative means of determining active disease sites, prognosis of future sites of breakdown, and response to therapy. This review highlights the potential array of biomarkers present in gingival crevicular fluid and which may relate to existing or predicted tissue regions undergoing metabolic change and derived from bacterial or host-cell-derived products. Among the former may be listed endotoxin, amines, butyrate, and a variety of enzymes and their inhibitors, such as trypsin-like proteases and bacterial collagenase. Arising from host cells is a variety of leucocytic hydrolase enzymes, lactoferrin, and lysozyme. These appear to be useful inflammatory markers and may be distinguished from products of connective tissue breakdown which include collagenous and non-collagenous products, including collagen peptides, osteonectin, and fibronectin. The proteoglycans have found particular favor as biomarkers of possible bone-resorptive activity. Attention has also been directed at the immune response, including comment on immunoglobulins, complement, eicosanoids, and cytokines. This review lists available information on the presence of these in gingival sulcus fluid and wherever possible relates their presence to disease activity.

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Section: Collagensmentioning

confidence: 99%

Section: Other Connective Tissue Proteinsmentioning

confidence: 99%

Gingival Crevicular Fluid: Biomarkers of Periodontal Tissue Activity

Embery¹,

Waddington²

1994

Adv Dent Res.

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“…Also, salivary alkaline phosphatase levels may be useful as a potential bone turnover marker to establish the diagnosis and prognosis of periodontal disease (4). On the other hand, periodontal tissue destruction via osteoclastic action results in the sequestration of bone specific matrix proteins, like telopeptides type I collagen (5), osteocalcin (6), osteonectin (7), osteopontin (8) and bone phosphoprotein (9) in the gingival crevicular fluid, all of which have been positively associated with the progression of periodontal disease (10,11). …”

Section: Introductionmentioning

confidence: 99%

Effect of gingival application of melatonin on alkaline and acid phosphatase, osteopontin and osteocalcin in patients with diabetes and periodontal disease

Cutando¹,

López-Valverde²,

Gómez-de-Diego³

et al. 2013

Med Oral

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Objectives: To assess the effect of topical application of melatonin to the gingiva on salivary fluid concentrations of acid phosphatase, alkaline phosphatase, osteopontin, and osteocalcin. Study Design: Cross-sectional study of 30 patients with diabetes and periodontal disease and 30 healthy subjects. Diabetic patients were treated with topical application of melatonin (1% orabase cream formula) once daily for 20 days and controls with a placebo formulation. Results: Before treatment with melatonin, diabetic patients showed significantly higher mean salivary levels of alkaline and acid phosphatase, osteopontin and osteocalcin than healthy subjects (P < 0.01). After treatment with melatonin, there was a statistically significant decrease of the gingival index (15.84± 10.3 vs 5.6 ± 5.1) and pocket depth (28.3 ± 19.5 vs 11.9 ± 9.0) (P < 0.001). Also, use of melatonin was associated with a significant reduction of the four biomarkers. Changes of salivary acid phosphatase and osteopontin correlated significantly with changes in the gingival index, whereas changes of alkaline phosphatase and osteopontin correlated significantly with changes in the pocket depth. Conclusions: Treatment with topical melatonin was associated with an improvement in the gingival index and pocket depth, a reduction in salivary concentrations of acid phosphatase, alkaline phosphatase, osteopontin and osteocalcin. Key words:Melatonin, diabetes mellitus, alkaline phosphatase, acid phosphatase, osteopontin, osteocalcin.

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“…Griffiths et al .,[101] Isik et al .,[102] Kunimatsu et al .,[103] Nakashima et al .,[104] demonstrated significantly elevated levels of Osteocalcin, a bone turnover marker in GCF of patients with periodontal breakdown. Elevated levels of Osteonectin[105] and Osteopontin,[106107]) detected in GCF with progressive increase in periodontal breakdown. Root resorption markers like dentin matrix protein-1, dentin phosphophoryn and dentin sialoprotein had significantly high concentrations in GCF of teeth showing severe root resorption.…”

Section: Rank-rankl-opgmentioning

confidence: 99%

Understanding the advances in biology of orthodontic tooth movement for improved ortho-perio interdisciplinary approach

Patil

Shetty

Setty

et al. 2013

J Indian Soc Periodontol

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This article provides an insight on detailed current advances in molecular understandings of periodontal ligament cells and the influence of orthodontic force on them in the light of recent advances in molecular and genetic sciences. It sequentially unfolds the cellular events beginning from the mechanical force initiated events of cellular responses to bone remodeling. It also highlights the risks and limitations of orthodontic treatment in certain periodontal conditions, the important areas of team work, orthodontic expectations from periodontal treatment and the possibility of much more future combined research to improve the best possible periodontal health and esthetic outcome of the patient.

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Connective Tissue‐Associated Proteins in Crevicular Fluid:

Cited by 36 publications

References 20 publications

Gingival Crevicular Fluid: Biomarkers of Periodontal Tissue Activity

Gingival Crevicular Fluid: Biomarkers of Periodontal Tissue Activity

Effect of gingival application of melatonin on alkaline and acid phosphatase, osteopontin and osteocalcin in patients with diabetes and periodontal disease

Understanding the advances in biology of orthodontic tooth movement for improved ortho-perio interdisciplinary approach

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