Premenstrual dysphoric disorder (PMDD) affects countless women and girls globally; the symptoms are severe enough to generate impairment and distress. The hypothalamic-pituitary-adrenal axis is dysregulated in PMDD, according to previous research. However, few studies examine stress-related processes in real-time and in the real world among affected women. This research aims to analyze the individual and social factors of PMDD. The individual factor is discrimination. Especially for ethnic minority women, perceived discrimination can be toxic. Social factors include poverty, sexism, and abuse. Depression caused by a period of poverty is closely correlated with PMDD. Sexism might reduce the treatment efficacy of PMDD. Among early life traumas, emotional abuse is the most severe. The four factors: discrimination, poverty, sexism, and abuse, are closely related to PMDD. The article calls on the public to be aware of PMDD, and that society needs to treat women with PMDD fairly or even show more respect.