Connarus favosus Planch.: An inhibitor of the hemorrhagic activity of Bothrops atrox venom and a potential antioxidant and antibacterial agent

Silva, Thaís Pereira da; Moura, Valéria Mourão de; Souza, Maria Carolina Scheffer de; Santos, Vanessa Neves Carvalho; Silva, Kissinara A.M. Moreira da; Mendes, Mara Giselle Guimarães; Núñez, Cecília Veronica; Almeida, Patrícia Danielle Oliveira de; Lima, Émerson Silva; Mourão, Rosa Helena Veras; Dos-Santos, Maria Cristina

doi:10.1016/j.jep.2016.02.043

Cited by 18 publications

(12 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacterial infection secondary to snakebites is a common complication in envenomed victims [ 113 , 114 ]. The main source of bacteria is the oral cavity of snakes, but the microbiota in the different layers of the victim's skin or even microorganisms from victim's clothes could also contribute [ 115 , 116 ]. Abscess formation is a common complication found in patients bitten by Viperidae snakes, being a risk factor for amputation in these patients, and it may be associated with sepsis [ 113 , 114 , 117 ].…”

Section: Antivenom Activities Of Extracts Of Medicinal Plants Agaimentioning

confidence: 99%

“…The use of antibiotics following snakebites is often recommended, usually therapeutically than prophylactically, mainly to avoid complications due to infections [ 114 , 118 ]. In this context, medicinal plants presenting antimicrobial activities, especially against those microorganisms usually detected in snakebite victims' abscesses, could be interesting [ 115 ].…”

Section: Antivenom Activities Of Extracts Of Medicinal Plants Agaimentioning

confidence: 99%

See 1 more Smart Citation

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Félix-Silva

Silva-Júnior

Zucolotto

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects. Thus, the search for complementary alternatives for snakebite treatment is relevant. There are several reports of the popular use of medicinal plants against snakebites worldwide. In recent years, many studies have been published giving pharmacological evidence of benefits of several vegetal species against local effects induced by a broad range of snake venoms, including inhibitory potential against hyaluronidase, phospholipase, proteolytic, hemorrhagic, myotoxic, and edematogenic activities. In this context, this review aimed to provide an updated overview of medicinal plants used popularly as antiophidic agents and discuss the main species with pharmacological studies supporting the uses, with emphasis on plants inhibiting local effects of snake envenomation. The present review provides an updated scenario and insights into future research aiming at validation of medicinal plants as antiophidic agents and strengthens the potentiality of ethnopharmacology as a tool for design of potent inhibitors and/or development of herbal medicines against venom toxins, especially local tissue damage.

show abstract

Section: Antivenom Activities Of Extracts Of Medicinal Plants Agaimentioning

confidence: 99%

Section: Antivenom Activities Of Extracts Of Medicinal Plants Agaimentioning

confidence: 99%

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Félix-Silva

Silva-Júnior

Zucolotto

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Therefore, these enzymes can act as essential mediators of intracellular and intercellular signaling, hydrolyzing phospholipids and generating bioactive lipid mediators or messengers that control multiple cell functions and regulate a physiological and pathophysiological processes (Cechetti, Spadaro, Gessani, Podo, & Fantuzzi, ; Masud et al., ; Ramanadtham et al., ). Several plant extracts have been described with inhibitory activity on phospholipases A 2 and being efficient in inhibiting or preventing inflammatory processes, aiding in the management of inflammatory diseases (Kishore et al., ; Kuganesan et al., ; Moura et al., ; Silva et al., ). This inhibitory activity was attributed to phenolic compounds, such as gallic acid, ferulic acid, caffeic acid, propyl gallate, and epigallocatechin gallate, which showed to be effective in inhibiting the enzymatic and myotoxic activities induced by phospholipases A 2 (Guimarães et al., ; Pereanez, Nunez, Patino, Londono, & Quintana, ).…”

Section: Resultsmentioning

confidence: 99%

Fruit Bagasse Phytochemicals from Malpighia Emarginata Rich in Enzymatic Inhibitor with Modulatory Action on Hemostatic Processes

Marques

César

Braga

et al. 2018

Journal of Food Science

View full text Add to dashboard Cite

Agro‐industrial wastes are promising sources of phytochemicals for the development of products to be used in health promotion and maintenance. In this study, extracts from acerola bagasse (AB) were characterized by HPLC, and evaluated according to its modulatory action on phospholipases A2 and proteases involved in processes such as inflammation and blood clotting. Snake venoms were used as biological tools once they have high functional and structural homology between their enzymes and human enzymes. Two types of extracts were prepared from AB: aqueous and methanolic. These extracts, evaluated at different proportions (venom:extract, w:w), significantly inhibited the phospholipase activity induced by the venoms of Bothrops moojeni, Bothrops atrox (11% to 31%), and Crotalus durissus terrificus (C. d. t.) (11% to 19%). The hemolytic activity induced by the venoms of B. moojeni and C. d. t. was better inhibited by the methanolic extract (inhibition between 23% and 48%). Thrombolysis induced by the venoms of B. moojeni and C. d. t. was inhibited by both extracts, with inhibition ranging from 13% to 63% for the aqueous extract, and from 12% to 92% for the methanolic one. Both extracts increased the time of coagulation induced by the venoms of B. moojeni and Lachesis muta muta in 26 and up to 68 s. These inhibitory actions were related to the following phenolic compounds present in the extract of AB: gallic acid, catechin, epigallocatechin gallate, epicatechin, syringic acid, p‐coumaric acid, and quercetin. Additional studies are needed to confirm their potential use for nutraceutical purposes. Practical Application Agro‐industrial wastes are promising sources of phytochemicals for the development of products that can be used by pharmaceutical, cosmetics, and food industries. Studies report the use of the acerola bagasse extract in health improvement. However, its toxic‐pharmacological characterization is still scarce. In this study, the extracts of acerola bagasse presented phenolic compounds that can modulate the activity of enzymes such as phospholipases A2 and proteases that act on the coagulant/anticoagulant and thrombotic/thrombolytic activities and the break of phospholipids, decreasing the inflammation and platelet aggregation. Although the in vivo effects of the extracts are not fully understood, this study shed light upon the possibilities of their usage.

show abstract

“…These extracts are widely used in folk medicine, particularly to treat snakebites (7). Their efficacy as snakebite anti-venoms has been confirmed in vitro through the inhibition of the hemorrhagic activity of Bothrops atrox venom (5,6). However, several other medicinal properties need to be validated.…”

Section: Introductionmentioning

confidence: 99%

“…The first, from Plathymenia reticulata Bentham (Fabaceae), is rich in condensed tannins and phenolic compounds (5), while the second, from Connarus favosus Planch. (Connaraceae) is rich in condensed tannins, phenolic compounds, flavonoids, and catechins (6). These extracts are widely used in folk medicine, particularly to treat snakebites (7).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects ofPlathymenia reticulataandConnarus favosusAqueous Extracts against Cadmium- and Mercury-Induced Toxicities

et al. 2019

Self Cite

View full text Add to dashboard Cite

The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the Δycf1 mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.

show abstract

Connarus favosus Planch.: An inhibitor of the hemorrhagic activity of Bothrops atrox venom and a potential antioxidant and antibacterial agent

Cited by 18 publications

References 39 publications

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Fruit Bagasse Phytochemicals from Malpighia Emarginata Rich in Enzymatic Inhibitor with Modulatory Action on Hemostatic Processes

Protective Effects ofPlathymenia reticulataandConnarus favosusAqueous Extracts against Cadmium- and Mercury-Induced Toxicities

Contact Info

Product

Resources

About