Conjunctival Oxygen Tension Measurements for Assessment of Tissue Oxygen Tension during Pulmonary Surgery

Asmussen, J.; Gellett, S C; Pilegaard, Hans K.; Gottrup, Finn

doi:10.1159/000129358

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…While a few studies have questioned the use of conjunctival oxygen readings (30)(31)(32), others have found a role for conjunctival monitoring in pulmonary surgery and in resuscitation from shock (33)(34)(35). A possible role for conjunctival oxygen monitoring during cardiopulmonary resuscitation to help determine prognosis for recovery has also been described (36).…”

Section: Discussionmentioning

confidence: 99%

Monitoring the Conjunctiva for Carbon Dioxide and Oxygen Tensions and pH During Cardiopulmonary Bypass

Weiss¹,

Isenberg²,

McArthur³

et al. 2011

J Extra Corpor Technol

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The purpose of this study was to measure, for the first time, multiple physiologic parameters of perfusion (pH, PCO2, PO2, and temperature) from the conjunctiva of adult patients during cardiopulmonary bypass while undergoing cardiothoracic surgery. Ten patients who underwent either intracardiac valve repair, atrial septal defect repair, or coronary artery bypass graft surgery had placement of a sensor which directly measured pH, PCO2, PO2, and temperature from the conjunctiva. Data were stratified into seven phases (0–5 minutes prior to bypass; 0–5, 6–10, and 11–15 minutes after initiation of bypass; 0–5 minutes prior to conclusion of bypass; and 0–5 and 6–10 minutes after bypass) and analyzed using a mixed model analysis. The change in conjunctival pH over the course of measurement was not statistically significant (p = .56). The PCO2 level followed a quadratic pattern, decreasing from a mean pre-bypass level of 37.7 mmHg at baseline prior to the initiation of cardiopulmonary bypass to a nadir of 33.2 mmHg, then increasing to a high of 39.4 mmHg at 6–10 minutes post bypass (p < .01). The PO2 declined from a mean pre-bypass level of 79.5 mmHg to 31.3 mmHg by 6–10 minutes post bypass and even post-bypass, it never returned to baseline values (p < .01). Temperature followed a pattern similar to PCO2 by returning to baseline levels as the patient was re-warmed following bypass (p < .01). There was no evidence of any eye injury or inflammation following the removal of the sensor. In the subjects studied, the conjunctival sensor yielded reproducible measurements during the various phases of cardiopulmonary bypass without ocular injury. Further study is necessary to determine the role of conjunctival measurements in critical settings.

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Section: Discussionmentioning

confidence: 99%

Monitoring the Conjunctiva for Carbon Dioxide and Oxygen Tensions and pH During Cardiopulmonary Bypass

Weiss¹,

Isenberg²,

McArthur³

et al. 2011

J Extra Corpor Technol

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“…[11] keine Beziehung zwischen der transkonjunktivalen Sauerstoffspannung und dem zerebralen Blutfluß (CBF), gemessen mittels Xenon, beschrieben werden. Sie zogen den Schluss, dass nicht der Sauerstoffmangel das Absinken der Sauerstoffspannung in den Konjunktiven bewirkt, sondern die Hyperventilation zu einer Vasokonstriktion im konjunktivalen Gefäßbett führt.Andere Untersucher konnten den Einfluss der Hyperventilation nicht bestätigen [1,12]. Sie zogen den Schluss, dass nicht der Sauerstoffmangel das Absinken der Sauerstoffspannung in den Konjunktiven bewirkt, sondern die Hyperventilation zu einer Vasokonstriktion im konjunktivalen Gefäßbett führt.Andere Untersucher konnten den Einfluss der Hyperventilation nicht bestätigen [1,12].…”

Section: Transkonjunktivaler Sauerstoffpartialdruck (Pcjo 2 )unclassified

“…Rutherford et al [17] konnten an gesunden Probanden dann eine signifikante Korrelation zwischen dem CBF, gemessen mittels Positronen-Emissions-Tomographie (PET), und dem pcjO 2 /paO 2 -Index nachweisen, wenn der zerebrale Blutfluß mittels aktiver Hyperventilation variiert wurde. des pcjO 2 /paO 2 -Index im Gegensatz zur Xenon-Methode und der PET-Methode nicht möglich, einen kritischen Grenzwert der Perfusionseinschränkung zu definieren [1]. Darüber hinaus war es aufgrund der großen interindividuellen Streuung der pcjO 2 -Werte bzw.…”

Section: Transkonjunktivaler Sauerstoffpartialdruck (Pcjo 2 )unclassified

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Die Messung lokaler Sauerstoffparameter zur Detektion zerebraler Ischämien

et al. 2000

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During carotid endarterectomy the measurement of conjunctival oxygen tension is not useful to detect cerebral ischemia. The use of NIRS as a single neuronal monitor is not appropriate to perform, "selective shunting". In contrast to SEP, however, NIRS is characterized by its rapid changes immediately following carotid occlusion. This non invasive method is likely to complete the standard method SEP in a modified monitoring concept of neuronal function during carotid endarterectomy.

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Conjunctival Oxygen Tension Measurements for Assessment of Tissue Oxygen Tension during Pulmonary Surgery

Cited by 2 publications

References 14 publications

Monitoring the Conjunctiva for Carbon Dioxide and Oxygen Tensions and pH During Cardiopulmonary Bypass

Monitoring the Conjunctiva for Carbon Dioxide and Oxygen Tensions and pH During Cardiopulmonary Bypass

Die Messung lokaler Sauerstoffparameter zur Detektion zerebraler Ischämien

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