Conjunctival Lymphangiectasia: A Report of 11 Cases and Review of Literature

Successful Treatment of Conjunctival Lymphangiectasia With Subconjunctival Injection of Bevacizumab

“…14 Conjunctival lymphangiectasis may result from the obstruction of lymphatic vessels because of surgery, radiotherapy, or other disease processes. 1 The etiology of lymphangiectasis in our patient was unclear, but treatment was warranted because of persistent ocular irritation and redness. We have found that a single subconjunctival injection of bevacizumab resulted in a prompt and complete resolution of conjunctival lymphangiectasia in a patient with no recurrence and side effects of treatment observed at 36 months.…”

“…This simple intervention can spare the patient from undergoing surgery or the complications/high recurrence in other modalities. 1 Aman et al similarly reported the successful treatment of diffuse pulmonary lymphangiomatosis with bevacizumab. 15 Of interest, blocking VEGF-C has also been shown to suppress inflammation and lymphangiogenesis in mice …”

“…2 In such situations, treatment options include topical steroids, surgical excision, diathermy, liquid nitrogen cryotherapy, and highfrequency radio wave electrosurgery. [1][2][3] We describe a case of diffuse conjunctival lymphangiectasia successfully treated with a single injection of subconjunctival bevacizumab (Avastin), an antibody that binds to vascular endothelial growth factor-A (VEGF-A).…”

Conjunctival lymphangiectasia associated with classic Fabry disease

“…Presence or absence of CL was determined according to the definition of Welch et al 15 by the primary evaluator (MDS) and was independently observed in each case from the images by a second observer (WJB). Clinical data for patients included age, duration of ERT, mutation status, ocular symptoms and presence of peripheral lymphoedema.…”

“…Having assessed the ocular surfaces of tens of thousands of patients in clinical practice, the authors can attest to the rarity of CL in the general population. These lesions usually occur due to lymphatic stasis from trauma, atopy or neoplastic disease 15. We present the ocular findings and related symptoms for eight adult male and five adult female patients with classic FD, all of whom had received enzyme replacement therapy (ERT) for at least 4 years prior to evaluation.…”