Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models

Abdelkader, Hamdy; Ismail, Sayed; Hussein, Amal K.; Wu, Zimei; Al‐Kassas, Raida; Alany, Raid G.

doi:10.1016/j.ijpharm.2012.04.063

Cited by 77 publications

(67 citation statements)

References 25 publications

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“…No signs of irritation were observed for cornea, and conjunctiva of the treated eyes monitored at the different time intervals for 72 hours, compared with the contralateral control eyes. Similar results have been reported for conventional niosomal systems composed of Span 60:CH at surfactant/lipid concentrations up to 5% w/v employing in vitro models (Abdelkader et al, 2012a). These results could suggest the good ocular safety and tolerability for the developed nano-sized ethoniosomes and incorporation of ethanol (20%) into niosomes can be safely applied into the eye.…”

Section: Modified Draize's Eye Testsupporting

confidence: 84%

“…On another report, irritation scores based on an in vitro model of a total score ranged from 0 to 21. The scores were interpreted in more details as follow: slight irritation scored from 1 to 4.9, moderate irritation (5-8.9) and strong irritation (9-21) (Abdelkader et al, 2012a). This interpretation scheme was adopted in this study.…”

Section: Eye Irritancy Studymentioning

confidence: 99%

“…Niosomes can show many favorable physicochemical properties; such as physical and chemical stability, thermoresponsiveness and spreading ability on lipophilic corneal epithelium (Abdelkader et al, 2011), and in vivo ocular performance; such as enhanced transcorneal permeation and controlled drug release on the surface of the eye (Abdelkader et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

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Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

Gaafar

Abdallah

Farid

et al. 2014

Journal of Liposome Research

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Niosomes embodying ethanol and minimum amount of cholesterol (ethoniosomes) could be promising ocular delivery systems for water soluble and insoluble drugs. This manuscript reports on novel nano-sized elastic niosomes (ethoniosomes) composed of Span 60: cholesterol (7:3 mol/mol) and ethanol, for ocular delivery of prednisolone acetate (Pred A) and prednisolone sodium phosphate (Pred P). These ethoniosomes were prepared with the thin film hydration (TFH) and ethanol injection (EI) methods, characterized for percentage entrapment efficiency (% EE), size, zeta potential, morphology, elasticity, in vitro release and physical stability. Ocular irritation, bioavailability and anti-inflammatory effects were evaluated and compared with the conventional suspension and solution eye drops. The prepared ethoniosomal vesicles (EV) had a Z-average diameter of 267 nm, zeta potential of approximately -40 mV and % change in size after extrusion of 4%. They were physically stable for at least 2 months at 4 °C. The prepared EV showed good ocular tolerability using the modified Draize's test and the estimated relative ocular bioavailability for Pred A EV and Pred P EV was 1.54 and 1.75 times greater than that for the suspension and solution eye drops, respectively. The time required for complete healing from the clove oil-induced severe ocular inflammation was reduced to half with Pred A and Pred P EV. More interestingly, the intraocular pressure (IOP) elevation side effect recorded for Pred A and Pred P EV was significantly less than that for the conventional suspension and solution eye drops.

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Section: Modified Draize's Eye Testsupporting

confidence: 84%

Section: Eye Irritancy Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

Gaafar

Abdallah

Farid

et al. 2014

Journal of Liposome Research

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“…This study has revealed minimal ocular irritations indicating good ocular tolerability for niosomes (Abdelkader et al, 2012a).…”

Section: Toxicity Of Niosomesmentioning

confidence: 57%

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

2013

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Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such serve as versatile drug delivery devices of numerous applications. Additionally, niosomes can be considered as more economically, chemically, and occasionally physically stable alternatives to liposomes. Niosomes can be fabricated using simple methods of preparations and from widely used surfactants in pharmaceutical technology. Many reports have discussed niosomes in terms of physicochemical properties and their applications as drug delivery systems. In this report, a brief and simplified summary of different theories of self-assembly will be given. Furthermore manufacturing methods, physical characterization techniques, bilayer membrane additives, unconventional niosomes (discomes, proniosomes, elastic and polyhedral niosomes), their recent applications as drug delivery systems, limitations and directions for future research will be discussed.

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“…Niosomes can be used in drug targeting to various organs such as skin [21], liver [22, 23], lung [24, 25], and ocular systems [26, 27] due to their very small volume which can pass through the narrowest capillaries. They can remain in the blood stream for prolonged period because of their ability to avoid the phagocytes, and as a consequence, they are amenable to controlled and continuous release properties.…”

Section: Nonionic Surfactant Vesicles (Nsvs) Considerationsmentioning

confidence: 99%

Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives

Sahoo

Biswas

Guha

et al. 2014

BioMed Research International

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With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug delivery system like lacking of permeability through ocular barrier and poor bioavailability of water soluble drugs have been overcome by the emergence of NSVs. The drug loaded NSVs (DNSVs) can be fabricated by simple and cost-effective techniques with improved physical stability and enhance bioavailability without blurring the vision. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more subdisciplines expected to coexist in the near future. This review gives a comprehensive emphasis on NSVs considerations, formulation approaches, physicochemical properties, fabrication techniques, and therapeutic significances of NSVs in the field of ocular delivery and also addresses the future development of modified NSVs.

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Conjunctival and corneal tolerability assessment of ocular naltrexone niosomes and their ingredients on the hen's egg chorioallantoic membrane and excised bovine cornea models

Cited by 77 publications

References 25 publications

Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

Preparation, characterization and evaluation of novel elastic nano-sized niosomes (ethoniosomes) for ocular delivery of prednisolone

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

Nonionic Surfactant Vesicles in Ocular Delivery: Innovative Approaches and Perspectives

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