Conjugation of Glycans with Carbon Nanostructures

Michael, Zachary P.; Star, Alexander; Vidal, Sébastien

doi:10.1002/9781118860212.ch5

Cited by 2 publications

(1 citation statement)

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“…In a different context, we have recently designed nano‐detection devices using carbon nanotubes in field‐effect transistors (FET) for the detection of bacterial lectins such as LecA or LecB. The non‐covalent functionalization of the carbon nanotubes was achieved by π‐π stacking of pyrene‐based of porphyrin‐based glycoconjugates.…”

Section: Introductionmentioning

confidence: 99%

Cyclotriveratrylene‐Based Glycoclusters as High Affinity Ligands of Bacterial Lectins from Pseudomonas aeruginosa and Burkholderia ambifaria

et al. 2016

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The design of multivalent glycoconjugates has been largely studied using a variety of core scaffolds. Cyclotriveratrylenes (CTV) have been scarcely used in this context. The synthesis of the tri‐ and hexa‐propargylated CTV cores allowed the preparation of the corresponding glycoclusters with galactose or fucose residues through azide‐alkyne “click” chemistry. Their interactions with bacterial lectins (LecA, LecB and BambL) was confirmed and studied by titration microcalorimetry. Adsorption onto carbon nanotubes was then attempted based on the hydrophobic CTV cores. Their incorporation into field effect transistor (FET) devices was accomplished but the data collected largely suggested a poor interaction of CTV‐based glycoclusters with the carbon nanotubes leading to non‐specific detection of the lectins.

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Section: Introductionmentioning

confidence: 99%