Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability

Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo

“…[17][18][19] In addition, with its excellent hydrophilicity, high biocompatibility, nontoxic and nonirritant properties, HA is a favorable natural material for biomedical applications, such as cosmetics, 20 cell therapy, 21 tissue engineering 22 and drug delivery. [23][24][25] One of the advantages of using HA conjugation is that it improves the water solubility of hydrophobic drugs such as paclitaxel and curcumin [26][27][28] and provides the targeting ability for drug delivery system. HA of different molecular weights has various roles in the body.…”

Hyaluronic Acid in the 3^rd Millennium

“…The conjugation of P40 to HA successfully prevents its systemic absorption and, therefore, improves its topical therapeutic effect [180]. Other researches have shown that conjugation of curcumin with HA represents a strategy to enhance water solubility and stability of curcumin [181]. Moreover, HA-curcumin conjugate displays improved healing properties compared to free curcumin and free HA, both in vitro -wound model of human keratinocytes-and in vivo -wound model of diabetic mouse.…”

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

“…With a curcumin loading content of 25.3 wt.%, the Curc-OEG conjugate formed stable nanoparticles in aqueous solution and exhibited dramatic anticancer effect in vitro and in vivo without causing significant toxicity (123). Curcumin-polymer conjugates were also synthesized with hyaluronic acid (124) and polyvinylpyrrolidone (125). Most recently, Yang et al (126) demonstrated that the covalent curcumin-polymer conjugates can be further used to physically encapsulate additional curcumin.…”