Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

Zhang, Yifei; Huang, Yixian; Li, Song

doi:10.1208/s12249-014-0113-z

Cited by 295 publications

(153 citation statements)

References 128 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…Micelles accumulate at poorly vascularized tumors and enhance permeability and retention, and increase the half-life of anticancer agents. 44 They have been shown to overcome P-gp efflux, act through receptor-mediated endocytosis, and increase intracellular drug concentration with enhanced cytotoxicity in MCF-7/ doxorubicin-resistant cells. 45,46 Moreover, fabricated immune micelles (antibodies bound to the surface of micelles) were also used in breast adenocarcinomas.…”

Section: Organic Drug Delivery Approaches Micellesmentioning

confidence: 99%

Drug delivery approaches for breast cancer

Singh

Lillard

et al. 2017

IJN

174

View full text Add to dashboard Cite

Breast cancer is one of the most common cancers affecting women worldwide. The controlled release of drugs to the precise site of the disease using a nanocarrier vehicle increases the therapeutic efficiency of the drugs. Nanotechnology-based approaches used to endorse clinical improvement from a disease also help to understand the interaction of malignant cells with their microenvironment. Receptor-based targeting is another approach for drug delivery which is undergoing clinical trials. Nanoparticles (NPs) delivery has been proven to promise high loading capacity, less toxicity, and stability of the drugs or biomolecules compared to traditional chemotherapeutic drugs. The goal of this review is to present the current problems of breast cancer therapy and discuss the NP-based targeting to overcome the hurdles of conventional drug therapy approach.

show abstract

Section: Organic Drug Delivery Approaches Micellesmentioning

confidence: 99%

Drug delivery approaches for breast cancer

Singh

Lillard

et al. 2017

IJN

174

View full text Add to dashboard Cite

show abstract

“…Polymeric micelles, which are a type of drug carrier with a hydrophobic core and hydrophilic polyethylene glycol (PEG) shell, present an ideal choice for the effective delivery of anticancer drugs (particle size, 10-100 nm) with poor solubility (38,39). Compared with the free drug, drug-loaded polymeric micelles, which demonstrate a higher stability and biocompatibility in vitro and vivo, and a significantly increased blood circulation time, are transferred to the tumor site via active and passive targeting mechanisms.…”

Section: Polymeric Micellesmentioning

confidence: 99%

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer

et al. 2016

View full text Add to dashboard Cite

Abstract. Multidrug resistance (MDR) to chemotherapy presents a major obstacle in the treatment of cancer patients, which directly affects the clinical success rate of cancer therapy. Current research aims to improve the efficiency of chemotherapy, whilst reducing toxicity to prolong the lives of cancer patients. As with good biocompatibility, high stability and drug release targeting properties, nanodrug delivery systems alter the mechanism by which drugs function to reverse MDR, via passive or active targeting, increasing drug accumulation in the tumor tissue or reducing drug elimination. Given the potential role of nanodrug delivery systems used in multidrug resistance, the present study summarizes the current knowledge on the properties of liposomes, lipid nanoparticles, polymeric micelles and mesoporous silica nanoparticles, together with their underlying mechanisms. The current review aims to provide a reliable basis and useful information for the development of new treatment strategies of multidrug resistance reversal using nanodrug delivery systems. IntroductionAt present, chemotherapy remains the optimal choice for cancer therapy, and tumor multidrug resistance (MDR) is a major factor that reduces the efficacy of chemotherapy (1). MDR is a phenotype that tumor cells acquire, which confers resistance to certain chemotherapy drugs, as well as concurrent cross-resistance to additional antitumor drugs that have different structures or mechanisms of action (2,3). The complexity of MDR has impeded the study of reversal agents (3-5). In recent years, the application of nanotechnology for drug carrier design has resulted in the development of novel nanoparticle drug delivery systems that aim to reverse MDR (6-8). Inorganic nanodrug delivery systems, lipid-based systems and polymer nanodrug delivery systems are the most common nanodrug delivery systems, which exhibit non-toxic, biocompatible and highly stable properties (8,9). The application of nanoparticle drug delivery systems is increasing due to their advantage of controlled and targeted drug release (9,10). Studies have demonstrated that entrapped small molecule drugs (10-200 nm in diameter) are more conducive to drug uptake and efflux; these nanodrug particles function via passive and active mechanisms, whereas in the systemic blood circulation they exhibit sustained release that subsequently enhances intracellular drug accumulation in tumor cells, yielding an improved effect (1,(11)(12)(13)(14). In the present review, the application of nanoparticle drug delivery systems in reversing the MDR of tumors is reviewed, which may provide an improved understanding of novel strategies for cancer therapy. Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer (Review)YINGHONG HUANG 1 , SUSAN P.C. COLE 2 , TIANGE CAI 3 , and YU CAI

show abstract

“…Silk fibroin-derived curcumin nanoparticles found to be highly effective against breast cancer due to their local, sustained, and long-term therapeutic delivery [51]. Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs due to their ability to show prolonged circulation time in the blood and enhanced tumor accumulation [52].…”

Section: Therapeutic Application Of Nanoparticles For Tumor-targetingmentioning

confidence: 99%

Nanoparticles: A Promising Drug Delivery Approach

Kadian¹

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Nanoparticles are particles having a size range of 1 and 100 nanometers, defined as a small object behaving as a complete unit with respect to the drug transport and therapeutic properties. They have several advantages such as improvement in the intracellular infiltration, enhanced hydrophobic solubility, and circulation time of the drug. They reduce non-specific uptake and side effects of the conventional drug delivery systems. Nanoparticles offer more effective and convenient routes of administration (oral, pulmonary, parenteral, and transdermal) and used for drug delivery for treatment of cancer, diabetes, pain, asthma, allergy, infections, and so on. They allow targeted delivery and controlled release of the drug. Further research on their mechanism of action to meet better stability of nanoparticles in the biological system could be done.

show abstract

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

Cited by 295 publications

References 128 publications

Drug delivery approaches for breast cancer

Drug delivery approaches for breast cancer

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer

Nanoparticles: A Promising Drug Delivery Approach

Contact Info

Product

Resources

About