1997
DOI: 10.1016/s0024-3205(97)00166-5
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Conjugation-deconjugation cycling of diflunisal via β-glucuronidase catalyzed hydrolysis of its acyl glucuronide in the rat

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Cited by 19 publications
(9 citation statements)
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“…Indeed, the phase II enzyme activities contribute to eliminating potential carcinogens, while b-glucuronidase is involved in recirculating glucurono-conjugates. 34,35 More precisely, we describe an enhancement of the speci®c activities of microsomal GST and UGTÐ 4MU (1.7-fold) in the caeco-colon. In the liver, only the speci®c activity of microsomal GST increased and the concentration of CYP450 remained unchanged.…”
Section: Discussionmentioning
confidence: 87%
“…Indeed, the phase II enzyme activities contribute to eliminating potential carcinogens, while b-glucuronidase is involved in recirculating glucurono-conjugates. 34,35 More precisely, we describe an enhancement of the speci®c activities of microsomal GST and UGTÐ 4MU (1.7-fold) in the caeco-colon. In the liver, only the speci®c activity of microsomal GST increased and the concentration of CYP450 remained unchanged.…”
Section: Discussionmentioning
confidence: 87%
“…Hydrolysis might, however, occur intracellularly, followed by export of the resveratrol formed into the circulation by passive diffusion (Maier-Salamon et al, 2006) or via an as-yet-unidentified transporter. Intracellular deglucuronidation is not without precedent, because HepG2 cells can form quercetin from quercetin-glucuronide (O'Leary et al, 2003); moreover, diflunisal-glucuronides are deglucuronidated by rat liver during perfusion experiments (Brunelle and Verbeeck, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…This can result in conjugation–deconjugation cycling that does not involve enterohepatic recirculation, as documented for the drug diflunisal. Treatment of rats with a specific β-glucuronidase inhibitor decreased metabolic clearance of diflunisal by 54% in experiments in which the bile duct was cannulated to prevent enterohepatic recirculation (Brunelle and Verbeeck 1997). Deconjugation of a variety of other xenobiotic metabolites has been documented in human liver preparations, including acetaminophen (Bohnenstengel et al 1999) and the aromatic amines benzidine and 4-aminobiphenyl (Zenser et al 1999).…”
Section: Why Rapid Metabolism Is Not the End Of The Storymentioning
confidence: 99%