Conjugated Polymers as Optical Probes for Protein Interactions and Protein Conformations

Herland, Anna; Inganäs, Olle

doi:10.1002/marc.200700281

Cited by 105 publications

(60 citation statements)

References 78 publications

(116 reference statements)

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“…In particular, the large absorption cross-section and collective optical response of CPEs make them superior in the transduction of optical signals [10], ultimately giving rise to higher sensitivity with lower signal-to-noise ratio as compared to small-molecule fluorophores [11]. To date, CPEs have been successfully applied to detect a variety of biomolecules, including nucleic acid [12][13][14][15][16][17][18], peptide [19], protein [20][21][22][23][24][25][26], adenosine triphosphate [27], amines [28], folic acid [29] and glucose [30].…”

Section: Introductionmentioning

confidence: 99%

Conjugated polyelectrolytes for label-free visual detection of heparin

Zhan

Liang

et al. 2011

Sci. China Chem.

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Conjugated polyelectrolytes (CPEs), with electron-delocalized backbones and charged ionic side chains, are unique sensory materials for the construction of optical biosensors. In this feature article, CPE-based visual detection of heparin is summarized. Three CPE-based heparin probes, including ratiometric, light-up and colormetric probes, are discussed in terms of molecular design, detection selectivity and quantification capability. The work summarized here provides fundamental guidelines for CPE-based label-free visual sensing. conjugated polyelectrolyte, heparin, fluorescence resonance energy transfer, sensor

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Section: Introductionmentioning

confidence: 99%

Conjugated polyelectrolytes for label-free visual detection of heparin

Zhan

Liang

et al. 2011

Sci. China Chem.

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“…[1][2][3][4][5] Especially interesting are stimulus-induced changes that take place in the electronic absorption and emission properties of these substances, which have been elegantly applied to the design of efficient chemosensors. [6][7][8][9][10][11][12][13][14][15][16][17] Thus, a variety of conjugated polymers have been constructed which undergo color and fluorescence transitions upon environmental perturbation.…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Conjugated Polymer Supramolecules with Tunable Colorimetric Responses

Ahn

Lee

Kim

2009

Adv Funct Materials

170

151

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Polydiacetylenes (PDAs), a family of highly π‐conjugated polymers, have unique characteristics associated with their ability to self‐assemble. Disruption of the extensively delocalized enyne backbones of molecularly ordered PDA sidechains induces a blue‐to‐red color change, which has been elegantly applied in the design of chemosensors. Recently, colorimetrically reversible PDAs have received significant attention, not only to gain a better understanding of the fundamentals of PDA chromism, but also to develop methodologies to overcome limitations associated with their colorimetrically irreversible counterparts. In this article, recent progress made in the field of colorimetrically tunable (reversible, stable, or sensitive) PDAs is described. Major emphasis is given to rational design strategies developed in our group. Relevant mechanistic investigations, a diagnostic method to test colorimetric reversibility, as well as future challenges in this area will be also discussed.

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“…Analyte‐induced aggregation and conformational change have also been demonstrated to influence the luminescence, which could be further explored for CP‐based sensing . Since several comprehensive review papers about sensing applications of CPs have previously been published, here we briefly introduce the recent progress in the use of water soluble CPs and cross‐linked CPs for luminescent sensing.…”

Section: Luminescent Conjugated Polymers For Sensingmentioning

confidence: 99%

Polymers for Luminescent Sensing Applications

Kim

Chang

2014

Macro Chemistry & Physics

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presence of an analyte is fi rst detected by interaction with a receptor and is then followed by the transduction of this binding event into a measurable signal. [ 2 ] Selectivity and sensitivity are the most important requirements of a sensor. The selectivity of a chemical sensor is very dependent on its receptor. To attain high selectivity, specifi c interaction between the receptor and an analyte should exist. [ 3 ] Polymers used for chemical sensing applications can be classifi ed into two categories: polymers interacting with analyte molecules in a receptor and those functioning in a transducer with generating signals. Molecularly imprinted polymers (MIPs) are an interesting class of polymers designed as artifi cial receptors. Conjugated polymers (CPs) are typical Polymers are widely used for chemical sensing applications, as a receptor or as a signal transducer. Fluorescent conjugated polymers (CPs) are extensively studied for signaling. Water-soluble CPs are particularly attractive due to their potential sensing applications in environmental and biorelated fi elds. The CPs by themselves do not provide specifi c binding sites by folding into secondary or tertiary structures. Molecularly imprinted polymers (MIPs) are artifi cial receptors fabricated using the molecular-imprinting technique. They contain in-built information about the shape and functionality of specifi c potential analytes. However, most MIPs do not have optical-signaling properties. In this article, the recent developments regarding luminescent polymeric sensors are briefl y summarized. It will be of great interest if the optical-signal properties of CPs and the selectivity of MIPs are integrated in an advanced polymeric sensor.

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Conjugated Polymers as Optical Probes for Protein Interactions and Protein Conformations

Cited by 105 publications

References 78 publications

Conjugated polyelectrolytes for label-free visual detection of heparin

Conjugated polyelectrolytes for label-free visual detection of heparin

Rational Design of Conjugated Polymer Supramolecules with Tunable Colorimetric Responses

Polymers for Luminescent Sensing Applications

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