Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats

Inoue, Nao; Nagao, Koji; Hirata, Junichi; Wang, Yu Ming; Yanagita, Teruyoshi

doi:10.1016/j.bbrc.2004.08.139

Cited by 70 publications

(39 citation statements)

References 34 publications

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“…Recently, CLAs have received attention because of their anti-obesity effect [1], anti-hypertensive effect [2], and anti-cancer effect [3]. In particular, it has been reported that dietary CLA decreases body fat and body mass [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Production of phosphatidylcholine containing conjugated linoleic acid mediated by phospholipase A2

Yamamoto

Hosokawa

Miyashita

2006

Journal of Molecular Catalysis B: Enzymatic

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Esterification of lysophosphatidylcholine (LPC) with conjugated linoleic acid (CLA) was carried out using porcine pancreatic phospholipase A 2 (PLA 2 ). PLA 2 only slightly synthesized phosphatidylcholine containing CLA (CLA-PC) at 2.6% by the addition of water. Addition of formamide in place of water markedly increased the yield of CLA-PC. In addition, synthesis of CLA-PC by PLA 2 was affected by the amount of substrate CLA and PLA 2 in the reaction system. Under optimal reaction conditions using 11 mg LPC, 18 mg CLA, 550 mg glycerol, 50 μL formamide, 3.3×104 U PLA 2 , and 0.3 μmol CaCl 2 at 37 o C for 6 h, the reaction yield of CLA-PC reached 65 mol%. Furthermore, addition of protein such as albumin and casein suppressed the decrease of CLA-PC yield after 6 h. In addition, PLA 2 exhibited the highest activity for the 10t,12c-CLA isomer among four CLA isomers (9c,11t-CLA, 9c,11c-CLA, 9t,11t-CLA and 10t,12c-CLA), whereas that for 9c,11c-CLA was the lowest. These results showed that the present esterification system for LPC and CLA by PLA 2 is effective for producing CLA-PC.

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Section: Introductionmentioning

confidence: 99%

Production of phosphatidylcholine containing conjugated linoleic acid mediated by phospholipase A2

Yamamoto

Hosokawa

Miyashita

2006

Journal of Molecular Catalysis B: Enzymatic

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“…In spontaneously hypertensive rats (SHR), blood pressure was normalized after CLA treatment. This effect was manifest in obese and non-obese animals [61,62]. However, the fact that a decrease in blood pressure was associated with a 30% reduction of fat mass raises the question whether this hypotensive effect was a consequence of the anti-obesity effect of CLA or not.…”

Section: In Animal Modelsmentioning

confidence: 86%

Effects of dietary conjugated linoleic acids in the control of adiposity and obesity‐related disorders

Quignard‐Boulangé¹,

Clouet²,

Schmitt³

2007

Euro J Lipid Sci & Tech

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Effects of dietary conjugated linoleic acids in the control of adiposity and obesity-related disordersThe body fat-lowering effect of conjugated linoleic acids (CLA) in experimental animals has attracted much interest because of the potential use of CLA as weight loss agents in humans. The objective of this review was to give an overview of the results from human intervention trials. The review also addresses experimental studies in animal models and in cultured cells. CLA appear to provoke fat mass loss and an increase of fat-free mass in rodents, but the results in humans are inconsistent and much less clear than in rodents. Thus, the results of studies in humans do not support a body fat-lowering effect of CLA. There are indications from animal studies that the trans-10, cis-12 CLA isomer induces liver steatosis and insulin resistance due to a redistribution of fat deposition. Some studies suggest that the trans-10, cis-12 isomer induces insulin resistance in obese subjects. In addition, no major effect of CLA on plasma lipids was detected in human studies. An overview of the potential mechanisms involved in the anti-obesity effect of CLA in animals and humans is provided. Do draw conclusions on CLA supplementation effects on human health, further human studies are required.

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“…[3][4][5] Therefore, an effect of CLA on BP could be expected in humans as well. A possible mechanism by which CLA and other trans fatty acids might influence blood pressure could be through endothelial function.…”

Section: Discussionmentioning

confidence: 99%

“…2 In addition, CLA was found to lower blood pressure (BP) in several rat models. [3][4][5] On the other hand, CLA is a trans fatty acid and its harmful effects on the cardiovascular system cannot be excluded. Little is known about the effect of CLA on human BP.…”

Section: Introductionmentioning

confidence: 99%

The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study

et al. 2011

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Cis-9, trans-11 conjugated linoleic acid (CLA) is a natural trans fatty acid that is largely restricted to ruminant fats and consumed in foods and supplements. Its role in blood pressure (BP) regulation is still unclear. We examined the effect of cis-9, trans-11 CLA on BP compared with oleic acid. A total of 61 healthy volunteers were sequentially fed each of 3 diets for 3 weeks, in random order, for a total of 9 weeks. The diets were identical except for 7% of energy (18.9 g in a diet of 10 MJ day -1 ) that was provided either by oleic acid, by industrial trans fatty acids or by cis-9, trans-11 CLA. We measured BP on two separate days at the end of each intervention period. At baseline, mean BP was 113.8 ± 14.4 mm Hg systolic and 66.3 ± 9.6 mm Hg diastolic. The effect of the CLA diet compared with the oleic acid diet was 0.11 mm Hg (95% confidence interval: À1.27, 1.49) systolic and À0.45 mm Hg (À1.63, 0.73) diastolic. After the industrial trans fatty acid diet, the effect was 1.13 mm Hg (À0.25, 2.51) systolic and À0.44 mm Hg (À1.62, 0.73) diastolic compared with the oleic acid diet. Our study suggests that short-term high intakes of cis-9,trans-11 CLA do not affect BP in healthy volunteers.

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Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats

Cited by 70 publications

References 34 publications

Production of phosphatidylcholine containing conjugated linoleic acid mediated by phospholipase A2

Production of phosphatidylcholine containing conjugated linoleic acid mediated by phospholipase A2

Effects of dietary conjugated linoleic acids in the control of adiposity and obesity‐related disorders

The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study

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