Congenital Toxoplasmosis: Late Appearance of Retinal Lesions After Treatment

Vroede, Monique De; Piepsz, Amy; Dodion, J; Verougstraete, Claire; Meuter, F. De

doi:10.1111/j.1651-2227.1979.tb18453.x

Cited by 7 publications

(4 citation statements)

References 4 publications

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“…These patients went through two to three month therapeutic cycles, with follow up exams by ophthalmologists, until it was clear that the lesions were healed. Late ocular lesions in children who have congenital toxoplasmosis is widely documented in the literature, including children adequately treated during the first year of life [9,27,28], confirming the necessity of an intensive follow up for these children.…”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil

Sáfadi¹,

Berezin²,

Farhat³

et al. 2003

Braz J Infect Dis

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We evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in Brazil, taking into consideration the shortage of national publications on this disease. Follow-up evaluations were made of 43 children with congenital toxoplasmosis referred to Santa Casa de São Paulo, during a period of at least five years. Selection of the cases was based in clinical and laboratory criteria. A clear predominance of children with subclinical presentation of the disease at birth (88%) was found. Of the 43 children, 22 (51%) developed neurological manifestations. Using skull radiography, we detected neuroradiologic alterations in seven children (16%) and with tomography in 33 children (77%). Neurological sequelae were identified in 15 children (54%) in the group with cerebral calcifications and in 7 (47%) in the group without cerebral calcifications. We observed chorioretinitis in 95% of the cases. Reactivation of cicatricial lesions and the emergence of new ocular lesions were observed in five cases. The most frequent neurological manifestation was a delay in neuropsychomotor development. Most remarkable was the finding that cerebral calcifications were not associated with a higher incidence of neurological sequelae among the children. Chorioretinitis was the main ocular sequel of the infection, found in nearly all children; it can manifest years from birth, even in children submitted to specific therapy during the first year of life, highlighting the importance of a follow-up of these children

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Section: Discussionmentioning

confidence: 82%

“…However, most of these children will develop sequelae during childhood or early adult life [4,5,6,7]. Studies have shown that even in infants with subclinical disease at birth and who have had appropriate therapy in the first year of life, there is risk of later appearance of ocular lesions [8,9,10].…”

mentioning

confidence: 99%

Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil

Sáfadi¹,

Berezin²,

Farhat³

et al. 2003

Braz J Infect Dis

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“…It was less in the first 4 years of life (approximately 23%) than after 5 years of age (40% to 50%). Thus localized ocular phenomena frequently develop as a late manifestation [245,359,361,400]. De Roever-Bonnet and colleagues [245] postulated that late development of eye lesions may be caused by second infections rather than by relapses, although supporting data for this hypothesis are lacking.…”

Section: Eye Chorioretinitismentioning

confidence: 99%

Toxoplasmosis

Remington¹,

McLeod²,

Wilson³

et al. 2011

Infectious Diseases of the Fetus and Newborn

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“…Some infected children without overt disease as neonates may escape serious consequences of the infection; however, a significant number develop chorioretinitis, strabismus, blindness, hydrocephalus or microcephaly, cerebral calcifications, developmental delay, epilepsy, or deafness months or years later. 6,7 Presentation only in the form haemolytic anaemia and hepatosplenomegaly is uncommon.…”

Section: Case Studymentioning

confidence: 99%