Congenital Temporary Diabetes Mellitus

Hutchison, John A.; Keay, A. J.; Kerr, Murray

doi:10.1136/bmj.2.5302.436

Cited by 57 publications

(13 citation statements)

References 10 publications

(5 reference statements)

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“…The child was still well at 4 years. It was not until 1962 that Hutchinson, Keay and Kerr [4] distinguished what they called 'Congenital temporary diabetes mellitus' from permanent neonatal diabetes. Cornblath and Schwartz were the first to call the condition 'Transient Neonatal Diabetes Mellitus' [5].…”

Section: Introductionmentioning

confidence: 98%

6q24 transient neonatal diabetes

Temple

Shield

2010

Rev Endocr Metab Disord

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Transient Neonatal Diabetes (type 1) is the commonest cause of diabetes presenting in the first week of life. The majority of infants recover by 3 months of age but are predisposed to developing type 2 diabetes in later life. It is associated with low birth weight but rapid catch up by 1 year of life. The condition is usually due to genetic or epigenetic aberrations at an imprinted locus on chromosome 6q24 and can be sporadic or inherited. Early diagnosis alters medical treatment strategies and differentiates it from other types of early onset diabetes. In some individuals, diabetes may be the initial presentation of a more complex imprinting disorder due to recessive mutations in the gene ZFP57 and may be associated with other developmental problems.

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Section: Introductionmentioning

confidence: 98%

6q24 transient neonatal diabetes

Temple

Shield

2010

Rev Endocr Metab Disord

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“…Our experience has been different, and we are, therefore, reporting this further series of hypoglycaemic dysmature infants. Neligan et al (1963), Engleson and Zetterqvist (1957), and Hutchison, Keay, and Kerr (1962), commented upon the similarity in appearance between such infants and infants with temporary neonatal hyperglycaemia. One of our patients with symptomatic hypoglycaemia developed temporary neonatal hyperglycaemia and required insulin therapy.…”

mentioning

confidence: 99%

Hypoglycaemia and temporary hyperglycaemia in infants of low birth weight for materity.

Chance¹,

Bower²

1966

Archives of Disease in Childhood

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“…It is noteworthy that 3 out of the 4 cases previously described by Hutchison, Keay, and Kerr (1962) were found to be mentally retarded but not spastic when examined later. While 2 of their patients had had hypoglycaemic episodes during treatment these did not occur in the present case.…”

Section: Case Historymentioning

confidence: 81%

Insulin studies in temporary neonatal hyperglycaemia.

Dune¹

1971

Archives of Disease in Childhood

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Congenital Temporary Diabetes Mellitus

Cited by 57 publications

References 10 publications

6q24 transient neonatal diabetes

6q24 transient neonatal diabetes

Hypoglycaemia and temporary hyperglycaemia in infants of low birth weight for materity.

Insulin studies in temporary neonatal hyperglycaemia.

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