Congenital Spinal Cysts: An Update and Review of the Literature

McNutt, Sarah; Mrowczynski, Oliver; Lane, Jessica; Jafrani, Ryan; Rohatgi, Pratik; Specht, Charles S.; Tubbs, R. Shane; Zacharia, Thomas; Rizk, Elias

doi:10.1016/j.wneu.2020.08.092

Cited by 10 publications

(30 citation statements)

References 345 publications

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“…This entity is a benign developmental lesion of endodermal origin. 2,3,[11][12][13] Its pathogenesis is not fully understood, but probably arises after failure of obliteration of the neurenteric canal, with displacement of endodermal cells. It is more commonly found in the spine, rarely as an encephalic lesion.…”

Section: Discussionmentioning

confidence: 99%

“…It is more commonly found in the spine, rarely as an encephalic lesion. 2,[11][12][13] Histologically, the cyst is lined by gastrointestinal or respiratory-type epithelium, with or without cilia, cuboidal to columnar, and simple to pseudostratified. It is sometimes impossible to histologically distinguish a Rathke cleft cyst from an enterogenous cyst; the former is often diagnosed when the lesion is intra-or suprasellar.…”

Section: Discussionmentioning

confidence: 99%

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Enterogenous Cyst and Glioblastoma: A Brief Histopathological Review of Two Uncommon Cystic Lesions of the Central Nervous System

Cambruzzi

Ferreira

et al. 2022

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Intracranial cystic lesions are common findings in cerebral imaging and might represent a broad spectrum of conditions. These entities can be divided into nonneoplastic lesions, comprising Rathke cleft cyst, arachnoid cyst, and colloid cyst, as well as neoplastic lesions, including benign and malignant components of neoplasms such as pilocytic astrocytoma, hemangioblastoma, and ganglioglioma. Surgical resection and histological evaluation are currently the most effective methods to classify cysts of the central nervous system. The authors report two uncommon cases presenting as cystic lesions of the encephalic parenchyma—a enterogenous cyst and a glioblastoma—and discuss typical histological findings and differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Enterogenous Cyst and Glioblastoma: A Brief Histopathological Review of Two Uncommon Cystic Lesions of the Central Nervous System

Cambruzzi

Ferreira

et al. 2022

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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“…5 Secondary causes of cyst formation such as infection, trauma and surgical procedures including lumbar myelography and laminectomy have been reported, but are less common. 1,2,5,[8][9][10] The mechanism of cyst formation is poorly understood and multiple theories have been proposed including osmotic gradients resulting in fluid shifts, and active fluid secretion from the cyst itself. 3,5 Additionally, inflammatory adhesions of the arachnoid layer are known to form arachnoid webs.…”

Section: Neurospine Eissn 2586-6591 Pissn 2586-6583mentioning

confidence: 99%

“…1,2,5,[8][9][10] The mechanism of cyst formation is poorly understood and multiple theories have been proposed including osmotic gradients resulting in fluid shifts, and active fluid secretion from the cyst itself. 3,5 Additionally, inflammatory adhesions of the arachnoid layer are known to form arachnoid webs. 11 Such arachnoid granulations have been postulated to create a one-way valve mechanism entrapping circulating cerebrospinal fluid (CSF), ultimately leading to the formation of SAC.…”

Section: Neurospine Eissn 2586-6591 Pissn 2586-6583mentioning

confidence: 99%

“…[1][2][3][4] The majority of these cysts are thoracic in nature and are more common in men with a peak incidence in the second decade of life. [1][2][3]5,6 SAC are classified into 3 subtypes. Type 1 cysts are extradural (EACs) without nerve root involvement, type 2 cysts are EACs with nerve root involvement, and type III cysts are intradural meningeal cysts.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Surgical Timing on Neurological Outcomes for Spinal Arachnoid Cyst: A Single Institution Series

Chatain

Shrestha²,

Kortz³

et al. 2022

Neurospine

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Objective: Spinal arachnoid cysts (SACs) are rare lesions that often present with back pain and myelopathy. There is a paucity of literature evaluating the impact of surgical timing on neurological outcomes for primary SAC management. To compare long-term neurological outcomes in patients who were managed differently and to understand natural progression of SAC.Methods: We conducted a retrospective analysis of adult patients treated for SAC at our institution from 2010 to 2021, stratified into 3 groups (conservative management only, surgical management, or conservative followed by surgical management). Study outcome measures were neurological outcomes as measured by modified McCormick Neurologic Scale (MNS), postoperative complications, and cyst recurrence. Nonparametric analysis was performed to evaluate differences between groups for selected endpoints.Results: Thirty-six patients with SAC were identified. Eighteen patients were managed surgically. The remaining 18 patients were managed conservatively with outpatient serial imaging, 7 of whom (38.9%) ultimately underwent surgical treatment due to neurological decline. Most common presenting symptoms included back pain (50.0%), extremity weakness (36.1%), and numbness/paresthesia (36.1%). Initial/preoperative (p = 0.017) and 1-year postoperative (p = 0.006) MNS were significantly different between the 3 groups, but not at 6 weeks or 6 months postoperatively (p > 0.05). Additionally, at 1 year, there was no difference in MNS between patients managed surgically and those managed conservatively but ultimately underwent surgery (p > 0.99).Conclusion: Delayed surgical intervention in minimally symptomatic patients does not seem to result in worse long-term neurofunctional outcomes. At 1 year, postoperative MNS were significantly higher in both surgical groups, when compared to the conservative group highlighting worsening clinical picture regardless of preoperative observational status.

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Differential Diagnosis of Intraspinal Arachnoid Cysts

Akhaddar

2023

Arachnoid Cysts

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Congenital Spinal Cysts: An Update and Review of the Literature

Cited by 10 publications

References 345 publications

Enterogenous Cyst and Glioblastoma: A Brief Histopathological Review of Two Uncommon Cystic Lesions of the Central Nervous System

Enterogenous Cyst and Glioblastoma: A Brief Histopathological Review of Two Uncommon Cystic Lesions of the Central Nervous System

Impact of Surgical Timing on Neurological Outcomes for Spinal Arachnoid Cyst: A Single Institution Series

Differential Diagnosis of Intraspinal Arachnoid Cysts

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