Congenital Perceptive Deafness: Role of Intrauterine Rubella

Gumpel, Shirley M.; Hayes, Kathleen; Dudgeon, J. A.

doi:10.1136/bmj.2.5757.300

Cited by 32 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Apart from these all but one of the children with deafness alone had a birthweight above 2 8 kg and all except this child had subsequent heights and weights above the 10th centile. This bears out what has been previously shown (Gumpel, Hayes, and Dudgeon, 1971), that children whose only defect resulting from intrauterine rubella is deafness may have an average birthweight and subsequent normal physical development.…”

Section: Resultssupporting

confidence: 86%

Clinical and Social Status of Patients with Congenital Rubella

Gumpel¹

1972

Archives of Disease in Childhood

Self Cite

View full text Add to dashboard Cite

Gumpel, S. M. (1972). Archives of Disease in Childhood, 47, 330. Clinical and social status of patients with congenital rubella. Eighty-five older patients with congenital rubella attending The Hospital for Sick Children were reassessed, paying special attention to their development and adaptation to their handicaps.They were a very handicapped group of children, nearly all were deaf, over twothirds had ocular defects, and over half had cardiac defects. 15 children had a single defect. Abnormal finger patternings were present in 35 %, but 21% of the mothers of these children had similar patterning. Only 9 children attended normal schools, the rest attended partial hearing units of residential schools for the deaf, and 24 children were in residential care for the mentally subnormal. Of the patients who had left school, 3 work in sheltered workshops, and 4 work as unskilled labour. No patient known to have had rubella antibody has lost antibody and there was no loss of immunological competence.In the past 30 years rubella has been clearly identified as a cause of fetal damage. Much information has been collected on the progress of the severely handicapped child up to school age (Sheridan, 1964), but less is known about his further prospects, and of the children with less severe handicaps.Since 1962 the staff of the Department of Microbiology have made a special study of the relation between infection in pregnancy and congenital defects, and in particular into the effect of rubella as a cause of fetal damage. As part of this study, it was felt that all the patients seen and closely studied during their earlier years should be reassessed, paying special attention to their development and adaptation to their handicaps, together with their antibody and immunological status.Among the important recent work on rubella, two aspects were particularly relevant to this study: firstly, the work of Menser, Dods, and Harley (1967) from Sydney, where they reported a 25-year follow-up of a group of patients with congenital rubella, and showed that many of these patients had become well adjusted despite severe handicaps; and secondly, the work of Kenrick et al. (1968) and Hardy et al. (1969) in which a few patients with

show abstract

Section: Resultssupporting

confidence: 86%

Clinical and Social Status of Patients with Congenital Rubella

Gumpel¹

1972

Archives of Disease in Childhood

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other studies have also reported between 40% and 75% of deaf seropositive children had such a maternal history [24]. …”

Section: Discussionmentioning

confidence: 99%

Congenital rubella syndrome in Iran

2005

View full text Add to dashboard Cite

Background: Congenital rubella syndrome (CRS) can be prevented with appropriate vaccination programs. The prevalence rates of rubella and CRS in Iran are unknown; therefore, the risk of exposure in pregnant women is not clear. The prevalence of CRS in the pre-vaccine period can be estimated by evaluating the proportion of children in the population with sensorineural hearing loss attributable to rubella.

show abstract

“…The serological means of diagnosis in our sample, together with the clinical evaluation of congenital defects at preschool age, allow the recognition of children infected in utero who were otherwise normal and the detection of late manifestations of congenital rubella such as deafness. In studies in which the diagnosis of rubella infection was based on serological grounds, it has been reported that children whose only defect is deafness may have a birthweight within normal limits (Gumpel, Hayes, and Dudgeon, 1971); furthermore, the mean birthweight of rubella deaf children did not differ significantly from the mean for children who were deaf for other reasons. However, when compared to standards for normal children, the mean birthweight of our deaf patients was significantly reduced.…”

Section: Discussionmentioning

confidence: 99%