Congenital nevocytic nevi and malignant melanomas

Kopf, Alfred W.; Bart, Robert S.; Hennessey, Patrick

doi:10.1016/s0190-9622(79)70009-0

Cited by 364 publications

(169 citation statements)

References 17 publications

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“…22,23 They are classified into three groups based on size: small (less than 1.5 cm), medium (1.5-19.9 cm), and large or giant (20 cm or greater). 24 Large congenital melanocytic nevi have an increased risk for the development of cutaneous and extracutaneous melanomas. [24][25][26] The overall incidence of malignant transformation of congenital melanocytic nevi ranges from 0.025 to 5.9% in different studies (2-42% in large congenital nevi) with very high risk during the first decade of life.…”

Section: Discussionmentioning

confidence: 99%

“…24 Large congenital melanocytic nevi have an increased risk for the development of cutaneous and extracutaneous melanomas. [24][25][26] The overall incidence of malignant transformation of congenital melanocytic nevi ranges from 0.025 to 5.9% in different studies (2-42% in large congenital nevi) with very high risk during the first decade of life. 25,26 The expression of fatty acid synthase in congenital nevi could represent either persistence of or regression to a fetal immunophenotype, since it is known that fetal cells express high levels of fatty acid synthase.…”

Section: Discussionmentioning

confidence: 99%

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Fatty acid synthase expression in cutaneous melanocytic neoplasms

et al. 2005

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Mammalian fatty acid synthase is a multifunctional enzyme complex involved in de novo synthesis of saturated fatty acids, and inhibitors of fatty acid synthase are being evaluated as potential therapeutic agents. Increased fatty acid synthase expression has been demonstrated in subsets of malignancies, including colon, breast, endometrium, prostate and ovarian carcinomas, and recently malignant melanomas. We evaluated the immunohistochemical expression of fatty acid synthase in 155 cutaneous melanocytic lesions. They included 30 congenital nevi, 19 compound nevi, 40 Spitz nevi, 48 primary melanomas, and 18 metastatic melanomas. Fatty acid synthase expression was stronger in malignant melanomas in comparison to conventional nevi and Spitz nevi, and was the highest for metastatic melanoma. Of the primary malignant melanomas, mean fatty acid synthase scores were significantly greater for Clark levels IV and V compared to Clark levels I and II (Po0.001). In addition, melanomas with Breslow thickness 0.75-1.50 mm and 41.50 mm showed significantly higher mean fatty acid synthase scores compared with those with Breslow thickness o0.75 mm (P ¼ 0.013 and o0.001, respectively). Of interest, congenital melanocytic nevi also showed strong fatty acid synthase expression, similar to that seen in metastatic melanoma. This may represent persistence of or regression to a fetal phenotype since normal fetal tissues are known to express high levels of fatty acid synthase.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fatty acid synthase expression in cutaneous melanocytic neoplasms

et al. 2005

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“…CMNs are usually classified according to their current size or the size that the CMN is predicted to attain at adulthood: small (less than 1.5 cm in diameter), medium (1.5∼20 cm) and large (more than 20 cm) 3 . The classification system is important because it has an effect on the management of CMNs.…”

Section: Introductionmentioning

confidence: 99%

A Combination of Dual-mode 2,940 nm Er:YAG Laser Ablation with Surgical Excision for Treating Medium-sized Congenital Melanocytic Nevus

Lim

Jeong

Whang³

2009

Ann Dermatol

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Background: There are various treatment options for congenital melanocytic nevus (CMN), including surgical excision, dermabrasions, curettage, laser treatment, chemical peels and cryosurgery. The proper choice of treatment depends on the size, location, thickness and clinical appearance of the nevi, the risk for developing melanoma, the psychological effect and the cosmetic component. Objective: The purpose of this study is to evaluate the outcome of a combination of surgical excision with Er: YAG laser ablation for treating CMNs. Methods: A total of 13 patients were included in this study. The nevus was excised as much as possible and only dermal suturing was performed, without epidermal suturing, for the primary closure. We then ablated the whole lesion, including the suture lines, by using a dual-mode 2,940 nm Er:YAG laser with three to five passes. All the lesions were followed up for 6 months and they were evaluated with respect to the healing status, infection, erythema, scarring, textural change and pigmentary change. Subject satisfaction was scored at the 16 th week by the patients. Results: Eleven (83%) of the 13 patients were clinically rated as having a good to excellent result by the physicians' Global Assessment Scale (GAS) scores for the lesions' reduction of size, the degree of scarring and the pigmentary change with only a one stage procedure. 10 (77%) of the total 13 patients reported a good to excellent result at four months after treatment. Conclusion: A combination of surgical excision with Er:YAG laser ablation as a one stage procedure is a safe, effective modality and it should be considered as one of the options for treating medium-sized CMNs.

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“…Buna göre <1,5 cm olanlar küçük, 1,5-19,9 cm olanlar orta, >20 cm olanlar da büyük konjenital nevüs olarak adlandı-rılmıştır. 6 KDN'lerde melanom gelişme riski bü-yüklükle doğru orantılı olarak artar. Bu hastalarda tüm yaşamları boyunca melanom gelişme riski %5-10 oranında bildirilmiştir.…”

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