Congenital malformations and assisted reproductive technique: Where is assisted reproductive technique taking us?

Tandulwadkar, Sunita; Lodha, Pooja; Kharb, Vineeta

doi:10.4103/0974-1208.106334

Cited by 7 publications

(8 citation statements)

References 13 publications

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“…This is because serious adverse events, of which fetal malformations is one category, were individually reported in all contraceptive efficacy studies and should have been reported to study investigators by the participant. Accordingly, these data are also consistent with the 4% congenital malformation rate that occurs during spontaneous pregnancies 64 and after artificial reproductive technologies 65 . Nevertheless, there is insufficient power to conclusively exclude the possibility that congenital malformation rates could be increased by MHC, even when all studies are aggregated.…”

Section: 6 Mhc Methods Do Not Increase Fetal Risksupporting

confidence: 87%

Male hormonal contraception: hope and promise

Piotrowska

Wang

Swerdloff

et al. 2017

The Lancet Diabetes & Endocrinology

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Family planning is a shared responsibility, but currently available male-directed methods are either not easily reversible (vasectomy) or not sufficiently effective (condom). Despite this, approximately 20% of couples using a contraceptive method worldwide, and up to 80% in some countries, choose a male-directed method. Male hormonal contraception (MHC) is acceptable and highly effective, with perfect use failure rates of 0.6% (95% confidence interval 0.3–1.1%) provided sperm concentration are maintained below 1 M/mL. Upon cessation of MHC, sperm quality fully recovers in a predictable manner resulting in pregnancies and live births. Spontaneous miscarriage and fetal malformation rates overlap that observed in the general population. Short-term adverse events, namely acne, night sweats, increased weight and altered mood and libido are recognized, but are generally mild. Further optimization of specific androgen-progestin regimens followed by Phase 3 studies of lead combinations is still required for successful development of an approved MHC and to determine long term adverse effects.

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Section: 6 Mhc Methods Do Not Increase Fetal Risksupporting

confidence: 87%

Male hormonal contraception: hope and promise

Piotrowska

Wang

Swerdloff

et al. 2017

The Lancet Diabetes & Endocrinology

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“…23 Similarly, increased numbers of congenital anomalies are described in infants born through the transfer of cryopreserved embryos. 24 2.5. Imprinting disorders Studies conclude that there is a correlation between assisted reproductive techniques and imprinting disorders.…”

Section: Congenital Abnormalitiesmentioning

confidence: 99%

Perinatal outcomes following assisted reproductive technology: A Review of the Literature

Papadatou¹,

Zachariou²,

Pergialiotis³

2022

HJOG

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Nowadays, infertility affects approximately 8-12% of the population. Μultiple causative factors are leading to the failure of subfertile couples to achieve a normal pregnancy, as well as various types of assisted reproductive techniques that have developed globally in order to confront infertility. Over the past few years, especially after the birth of the world’s first baby to be conceived by In Vitro Fertilization (IVF) in 1978, numerous studies have been conducted concerning the risk of obstetric and perinatal complications. In this review, we aimed to detail the perinatal outcomes in relation to the ART procedures routinely applied. Consequently, the above-mentioned procedures have been associated with the presentation of hypertensive disorders and gestational diabetes mellitus in women, multiple pregnancy, preterm birth and low birth weight. Furthermore, studies indicate that infants born from assisted reproductive technologies appear to suffer much more frequently not only by congenital or epigenetic abnormalities, but also by neurodevelopmental disorders and specific types of cancer. Indisputably, artificial fertilization methods still continue growing worldwide with new medical technologies’ evolvement. It becomes, therefore, evident that the possible long-term, adverse neonatal outcomes have not been completely clarified yet. Taking into consideration that the number of the couples that undergo fertility treatments is constantly rising, more research is of vital importance so that their potential impact of such exposure on maternal and neonatal health can be understood.

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“…Entre los factores de riesgo del PPT se considera el antecedente de parto pretérmino, de rotura prematura de membranas, aborto tardío o feto muerto, la existencia actual de embarazo gemelar o múltiple, polihidramnios, preeclampsia, infecciones urinarias y de transmisión sexual, malformaciones uterinas, incompetencia ístmico-cervical, conización cervical, edad materna mayor, tabaquismo, alcoholismo y uso de sustancias tóxicas, estrés físico y psicológico (16) , y ahora con cierta frecuencia, la gestación obtenida por técnicas de reproducción asistida (17) .…”

Section: Factores De Riesgo -Causasunclassified

Parto pretérmino, avances y retos. A manera de prólogo

Romero¹

2018

Rev peru ginecol obstet.

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El presente artículo es una introducción al simposio Enfoque perinatal del parto pretérmino, que incluye los temas de causalidad, manejo de la rotura prematura de membranas, avances en el manejo del bebe prematuro y futuro de la madre y el bebe. El prólogo incluye cifras que señalan cómo la incidencia de parto pretérmino ha continuado aumentando con el tiempo. Sin embargo, los avances peri y neonatológicos permiten una mayor y mejor sobrevida de los niños que nacen lejos de término y con peso muy bajo. Las medidas preventivas en la madre con riesgo también contribuyen a los mejores resultados perinatales.

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Congenital malformations and assisted reproductive technique: Where is assisted reproductive technique taking us?

Cited by 7 publications

References 13 publications

Male hormonal contraception: hope and promise

Male hormonal contraception: hope and promise

Perinatal outcomes following assisted reproductive technology: A Review of the Literature

Parto pretérmino, avances y retos. A manera de prólogo

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