Congenital lobar emphysema concurrent with pneumothorax and pneumomediastinum in a dog

Yun, Sungho; Lee, Ho-Hyun; Lim, Jae-Hyun; Lee, Kija; Jang, Kwang-Ho; Shiwa, Nozomi; Boonsriroj, Hassadin; Kimitsuki, Kazunori; Park, Chunho; Kwon, Youngho

doi:10.1292/jvms.15-0362

Cited by 16 publications

(35 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung lobectomy has been described for management of CLE, with a good outcome reported in 8 of 8 cases reported. [4][5][6][9][10][11]14,15 Congenital defects of bronchial cartilage commonly are associated with development of CLE in human infants. 2 Extramural bronchial obstructions, including vascular developmental abnormalities such as a pulmonary artery sling anomaly, also have been reported as causes of CLE.…”

Section: Introductionmentioning

confidence: 99%

Imaging findings in 14 dogs and 3 cats with lobar emphysema

Warwick¹,

Guillem

Batchelor

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Lobar emphysema in dogs and cats is caused by bronchial collapse during expiration and subsequent air trapping. Congenital causes such as bronchial cartilage defects or acquired causes such as compressive neoplastic lesions have been reported. Morbidity results from hyperinflation of the affected lung lobe and compression of adjacent thoracic structures.Objective: To describe patient characteristics and imaging findings in dogs and cats with lobar emphysema.Animals: Fourteen dogs and 3 cats with lobar emphysema diagnosed by imaging findings were retrospectively identified from veterinary referral hospital populations over a 10-year period.Methods: Cases that included thoracic radiography, thoracic computed tomography (CT), or both were included. All images were reviewed by a European College of Veterinary Diagnostic Imaging diplomate. Relevant case information included signalment, clinical findings, treatment, and histopathology where available.Results: Ten of 17 (59%) patients were presented for evaluation of dyspnea and 6 (35%) for coughing. Eleven (65%) patients were <3 years of age. The right middle lung lobe was affected in 12 cases (71%) and multiple lobes were affected in 7 cases (41%). Congenital lobar emphysema was suspected in 14 cases (82%). Conclusion and ClinicalImportance: Lung lobe hyperinflation, atelectasis of nonaffected lung lobes, mediastinal shift, and thoracic wall and diaphragmatic wall deformation were common findings. Lobar or multilobar emphysema should be considered in patients with dyspnea or coughing, particularly younger patients. Although radiography is useful, CT provides better detail. In older patients, acquired causes of bronchial compression should be considered.

show abstract

Section: Introductionmentioning

confidence: 99%

Imaging findings in 14 dogs and 3 cats with lobar emphysema

Warwick¹,

Guillem

Batchelor

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…CLE has been previously reported several times in dogs (Herrtage and Clarke 1985, Voorhout and others 1986, Amis and others 1987, Billet and Sharpe 2002, Stephens and others 2002, Matsumoto and others 2004, Gopalakrishnan and Stevenson 2007, Moon and others 2007, Ruth and others 2011, Yun and others 2016). Of the 11 dogs described in these case reports the breed was recorded for 10.…”

Section: Discussionmentioning

confidence: 87%

“…CLE is characterised by overinflation or hyperplasia of alveoli, typically within a single lung lobe. This condition leads to emphysema and pneumothorax and is most commonly seen in young animals (Herrtage and Clarke 1985, Voorhout and others 1986, Amis and others 1987, Billet and Sharpe 2002, Stephens and others 2002, Matsumoto and others 2004, Gopalakrishnan and Stevenson 2007, Moon and others 2007, Ruth and others 2011, Yun and others 2016). …”

Section: Introductionmentioning

confidence: 99%

Fatal pneumothorax in a dog caused by a lesion resembling congenital pulmonary airway malformation (CPAM) of children

Knight

Malaguti²,

Rajotte

et al. 2016

Vet Record Case Reports

View full text Add to dashboard Cite

An 8 month old boxer dog was referred for management of acute spontaneous pneumothorax. CT showed multiple variably sized bullae in the right middle lung lobe, and partial or complete atelectasis of all remaining lung lobes. This was assumed to be a case of congenital lobar emphysema (CLE). The dog was anaesthetised for surgery but died from cardiopulmonary arrest during presurgical thoracocentesis. Postmortem examination confirmed that ruptured bullae in the right middle lung lobe were responsible for the dog's pneumothorax and death. In addition, a malformation of the right subclavian artery was present. Histologically, the right middle lung lobe and primary bronchus were malformed, with microscopic changes resembling those of human congenital pulmonary airway malformation (CPAM), rather than CLE. CPAM has not been reported in the veterinary literature and should be considered in the differential diagnosis for spontaneous pneumothorax in dogs.

show abstract

“…This is a rare change that has been reported in nonlaboratory dogs. [169][170][171] The change is often associated with dyspnea. Laboratory dogs with this change would likely be culled prior to being used in toxicity studies.…”

Section: Commentmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

Woicke¹,

Al-Haddawi

Bienvenu³

et al. 2021

Toxicol Pathol

View full text Add to dashboard Cite

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/inhand.asp ) is a joint initiative of the societies of toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in most tissues and organs from the dog used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet ( http://www.goreni.org/ ). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions, lesions induced by exposure to test materials, and relevant infectious and parasitic lesions. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

show abstract

Congenital lobar emphysema concurrent with pneumothorax and pneumomediastinum in a dog

Cited by 16 publications

References 11 publications

Imaging findings in 14 dogs and 3 cats with lobar emphysema

Imaging findings in 14 dogs and 3 cats with lobar emphysema

Fatal pneumothorax in a dog caused by a lesion resembling congenital pulmonary airway malformation (CPAM) of children

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

Contact Info

Product

Resources

About