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Cited by 234 publications
(80 citation statements)
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References 20 publications
(24 reference statements)
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“…Transplantation of hepatocytes by intrasplenic injection in Gunn rats has been shown to decrease serum bilirubin concentrations (8,23). However, bilirubin levels also decreased after intrasplenic injection of Gunn rat hepatocytes, suggesting that decrease in bilirubin levels might have been due to interference with splenic bilirubin production (9).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Transplantation of hepatocytes by intrasplenic injection in Gunn rats has been shown to decrease serum bilirubin concentrations (8,23). However, bilirubin levels also decreased after intrasplenic injection of Gunn rat hepatocytes, suggesting that decrease in bilirubin levels might have been due to interference with splenic bilirubin production (9).…”
Section: Resultsmentioning
confidence: 99%
“…Transportation of hepatocytes (1)(2)(3), injection of hepatocyte extracts (1), and hepatocyte culture supernatants have been reported to prolong survival of rats with D(+)-galactosamine-induced liver injury (4) and animals with acute liver ischemia (5). Because homozygous Gunn rats lack UDP-glucuronosyltransferase activity for bilirubin, they cannot efficiently excrete bilirubin and, thus, exhibit lifelong nonhemolytic unconjugated hyperbilirubinemia (6)(7)(8). Hepatocyte transplantation has been used to impart the transferase activity in Gunn rats (9,10).…”
mentioning
confidence: 99%
“…It is also possible that supersaturated solutions of B F can persist in plasma without aggregation and precipitation. 43 Indeed, there is little evidence that precipitates of bilirubin commonly exist in icteric plasma (or other aqueous tissues of the body; exceptions being the renal papillary tip of the Gunn rat, 44 infected bile or tissues of terminally ill patients with kernicterus 45 ). Even in Crigler-Najjar patients with very high bilirubin levels or homozygous Gunn rats there is no evidence of precipitation or aggregation of bilirubin in the circulation, observations that are consistent with circular dichroism studies on serum albumin-bilirubin binding by Lehner and colleagues 46 and their conclusion that 'even at pathophysiological total concentrations of bilirubin, the unbound portion does not exceed the solubility limit'.…”
mentioning
confidence: 99%
“…The authors utilized the well-established Gunn rat model for CN disease, 2 which provides an attractive animal model to test gene therapy protocols for genetic diseases. CN disease type I is a rare inherited metabolic disorder caused by lack of the hepatic bilirubin uridine diphosho-glucuronosyltransferase (UGT1A1) activity, an enzyme which is responsible for the metabolic breakdown of bilirubin.…”
mentioning
confidence: 99%