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Cited by 10 publications
(6 citation statements)
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“…Once the technology to produce these vectors has been improved, and optimal stuffer DNA sequences have been identified, gutted adenoviruses might indeed become an important tool for liver-directed shRNA transfer. 78 …”
Section: Grimm and Ma Kaymentioning
confidence: 99%
“…Once the technology to produce these vectors has been improved, and optimal stuffer DNA sequences have been identified, gutted adenoviruses might indeed become an important tool for liver-directed shRNA transfer. 78 …”
Section: Grimm and Ma Kaymentioning
confidence: 99%
“…To ensure stable, long-term transgene expression and avoid side effects elicited by anti-adenoviral immune responses, high-capacity helper-dependent Adv vectors (HC-Adv) have been developed and tested. The second generation helper-dependent or ''gutless'', HC-Adv vectors were completely devoid of all viral coding sequences, which was proved to have a significantly favorable immunological profile and high capacity for extrinsic gene (*37 kbp) (Ehrhardt and Kay 2005;Candolfi et al 2006;Xiong et al 2006;Barcia et al 2007;King et al 2008). The transgene expression from HC-Adv remained stable for up to 1 year even in the presence of pre-existing systemic anti-adenoviral immune response (Barcia et al 2007).…”
Section: Modification Of Engineered Adenoviral Vectorsmentioning
confidence: 96%
“…For eventual translation to human use, the possibility that it might stimulate an immune response against the vector should be considered, but "gutted" AdV vectors have been developed that have minimal if any tendency to induce immune responses (Cao et al, 2004;Ehrhardt and Kay, 2005). Furthermore, the expression of FasL by the Guided Missiles would kill any T cells that may respond to AdV antigens.…”
Section: Adenoviral Vectors For Gene Deliverymentioning
confidence: 98%