Congenital ichthyosis patient with squamous cell carcinoma of the skin who received concurrent chemoradiation: A case report

Cerra-Franco, A.; Grethlein, Sara J.; Bertrand, Todd; Wooden, William A.; Saito, Naoyuki G.

doi:10.1016/j.adro.2017.09.006

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Recently, a case of SCC (in a 51-year old patient) and a case of melanoma (in a 54-year old patient) in association with ichthyosis vulgaris at relatively young ages have been reported. 3,4 A particular severe subtype of ichthyosis seems to be prone to skin cancers. However, there has been no report on the occurrence of skin cancers in patients with X-linked recessive ichthyosis.…”

Section: Discussionmentioning

confidence: 99%

“…1 There have been sporadic case reports of patients with various types of ichthyoses who developed skin cancers. [2][3][4][5] However, there has been no report of X-linked recessive ichthyosis with cutaneous malignancy. We report a rare case of X-linked recessive ichthyosis with basal cell carcinoma and discuss the risk of skin cancers in relation to ichthyosis.…”

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confidence: 99%

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Is X-linked Recessive Ichthyosis a High Risk for Basal Cell Carcinoma?

2020

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We report a case of X-linked recessive ichthyosis with basal cell carcinoma. An 86-year-old man was referred to our department for evaluation of a 1-year history of an ulcer on his left leg. He had suffered from dry skin with scales on his entire body since childhood. Histopathological examination of the lower leg revealed intradermal proliferation of a solid nest of basaloid cells showing unclear palisading in the periphery. Marked hyperkeratosis and hypergranulosis were also seen in the adjacent dermis. Loss of the steroid sulfatase gene was found on chromosome X. Based on these finding, we made a diagnosis of X-linked recessive ichthyosis with basal cell carcinoma. To our knowledge, there has been no report of X-linked recessive ichthyosis with cutaneous malignancy. We discuss the risk of skin cancer in relation to ichthyosis.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%