“…Similarly, filaggrin mutations are associated with greater risks for developing atopic dermatitis, a condition that is associated with higher risks for nonmelanoma skin cancer. Finally, some have speculated that the chronic inflammation associated with the impaired skin barrier in ichthyosis could contribute to carcinogenesis (Wakumoto et al, 2020). Despite these findings, the true relationship between ichthyosis and skin cancer risk remains unclear (Natsuga et al, 2011; Skaaby et al, 2014); however, given the potential association, some have suggested that patients with IV undergo lifelong skin cancer surveillance (Tas et al, 2017).…”