Congenital Hydronephrosis: Disease or Condition?

Petrovski, Mile; Симеонов, Ристо; Todorovikj, Lazar; Chadikovski, Vladimir; Memeti, Shaban; Petrovska, Branka; Risteski, Toni; Cvetanovska, Vesna

doi:10.2478/prilozi-2014-0016

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Congenital hydronephrosis is frequently encountered in pediatric urology resulting from ureteropelvic junction obstruction (UPJO). This disease results in many pathological and physiological problems, including renal interstitial edema, focal inflammatory cell infiltration, and degeneration and necrosis of renal tubular epithelial cells, thereby leading to fibrosis and atrophy of renal interstitium eventually [ 1 , 2 ]. Investigation on how to block or reverse the progress of renal tissue impairment is of great significance for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells

Liu

Qü

2020

Bosn J of Basic Med Sci

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Congenital hydronephrosis caused by ureteropelvic junction obstruction (UPJO) eventually leads to renal interstitial fibrosis and atrophy, after a series of pathophysiological problems. Renal repair after injury depends on renal stem cells. This study aimed to determine the expression of renal stem cell marker CD133 in children of different ages and the regulatory effect of stem cell microenvironment. Renal stem cells from children of different ages were identified and screened out by flow cytometry in the study. Children with hydronephrosis were divided into neonates, infants, preschool age, school age, and adolescents groups. A hypoxic cell model prepared with CoCl2 was developed to detect the effect of hypoxia on the proliferation and apoptosis of renal stem cells. The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. Both hypoxia and HIF-1α significantly promoted the proliferation of renal stem cells and inhibited cell apoptosis. HIF-1α could bind to the promoter region of proliferating cell nuclear antigen (PCNA) and PROM1 (CD133) to mediate their transcription and expression. The content of CD133+ renal stem cells was the highest in the neonatal group and it decreased with the increase of age. Taken together, this study clarified the effect of age on the content of human renal stem cells and determined the regulatory mechanism of hypoxia on renal stem cells. We expect our results to provide a research basis for the treatment and clinical application of renal stem cells.

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Section: Introductionmentioning

confidence: 99%

The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells

Liu

Qü

2020

Bosn J of Basic Med Sci

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“…To eliminate the cystoscopy and reduce the application of narcotic drugs, surgeons have made some advanced attempts in the procedures which were reported in the literature. [ 2 – 4 ] Nevertheless, they cannot be accepted by the physician and patients due to the obvious flaws in all these clinical trials, such as costliness, infection or uncomfortableness. In this report, a novel technique without cystoscope has been introduced to remove the retained double J stent under minimal sedation which evidently reduces operation time, costs, postoperative urination discomfort, and hospital stays compared with the cystoscope-assisted procedure.…”

Section: Introductionmentioning

confidence: 99%

Noncystoscopic removal of retained ureteral stents in children

Shao

Liu²,

Zhang³

et al. 2018

Medicine

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Cystoscopic technique is the current common method of retrieving double J ureteral stent in most pediatric urological centers. In this study, we evaluated the feasibility and efficacy of a novel noncystoscopic method to remove retained ureteral stents in pediatric patients.We reviewed all medical records from a total of 102 patients who were treated in our hospital between January 2013 and December 2016 to remove the double J ureteral stent retained into the ureter. The pediatric patients were divided into 2 groups based on different surgical options: cystoscopic group and noncystoscopic group. The surgery time (including time for instrument preparation), operation time, expenses, postoperative urination discomfort, and hospitalization were compared between the 2 groups.The noncystoscopic group took significantly less time for surgery and operation than the cystoscopic group (surgery time:7.40 ± 3.75 vs 18.42 ± 2.77 min, P <.05; operation time: 3.54 ± 2.03 vs 4.48 ± 2.04 min, P <.05). The mean spending for patients in the noncystoscopic group were less than that in the cystoscopic group ($736.70 ± 105.96 vs $618.23 ± 110.31, P <.05). There were less children with postoperative urination discomforts in the noncystoscopic group than that in the cystoscopic group (8 vs 20 cases, χ2 = 4.241, P <.05). The mean hospitalization of the noncystoscopic group was shorter than that of the cystoscopic group (3.20 ± 1.25 vs 4.13 ± 1.63 d, P <.05). The differences in all comparison projects were significant.The noncystoscopic procedure is a safe and viable technique that may be used successfully in pediatric urology. This novel procedure which is much safer and more affordable provides an alternative solution to remove retained ureteral stents in child patients.

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confidence: 99%

Colour Doppler and Biomarkers Utility for Renal Damage due to Congenital Hydronephrosis

Guo

Chen

Liu

2019

J Coll Physicians Surg Pak

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Congenital hydronephrosis, as one of the most common urinary system abnormalities is often found in children with ureteropelvic junction obstruction. [1][2][3] Finding effective, safe and minimally invasive indicators for congenital hydronephrosis evaluation has become a hotspot in current clinical research. Ultrasonography is an easy-to-use, non-invasive and non-radioactive means of examination that can detect morphological damage of hydronephrosis. However, using grayscale ultra-sonography to distinguish cases of mild hydronephrosis from normal cases showing fullness only, is relatively difficult. [4][5][6] Studies show that the levels of serum biomarkers, such as cystatin C (CysC),  2 -micro-globulin ( 2 -MG) and  1 -microglobulin ( 1 -MG) could be used to effectively evaluate renal function. [7][8] Previous studies find that serum CysC,  2 -MG may be potential biomarkers of obstruction in hydronephrosis. 9 The aim of this study was to evaluate the clinical value of colour doppler combined with serum CysC,  2 -MG and  1 -MG in the evaluation of congenital hydronephrosis, with a view to provide a reference for management of congenital hydronephrosis.

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Congenital Hydronephrosis: Disease or Condition?

Cited by 4 publications

References 28 publications

The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells

The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells

Noncystoscopic removal of retained ureteral stents in children

Colour Doppler and Biomarkers Utility for Renal Damage due to Congenital Hydronephrosis

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