Congenital Heart Disease and Maternal Diabetes Mellitus

Seyidov, Nabil; Petropoulos, Andreas; Khudiyeva, A; İsmailova, İ

doi:10.28942/ejcs.v1i4.36

Cited by 1 publication

(1 citation statement)

References 12 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to that, our OR (1.88) was within a narrow confidence interval (CI: 1.1-3.22). Petropoulos et al 30 concluded that the evidence sufficiently supports declaring pregnancies in mothers with gestational diabetes to have a similar risk to insulin-dependent diabetes mellitus in developing CHD, and to include them among the high-risk group needing fetal cardiac consultation. A possible cofounder that was overlooked is the association between pre-pregnancy BMI and the risk of CHD in offspring.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for transposition of the great arteries in Saudi population

Alfarhan

Alquayt

Alshalhoub

et al. 2020

SMJ

View full text Add to dashboard Cite

5¹«dAÃ« q¹b³ð-uDð vKŽ U¼dOŁQðË WKL²;« dD)« qÄ«uŽ rOOI²Ã ∫•«b¼_‫ا‬ AE©TGA® …dO³JÃ«-s¹cÃ« v{d*« lOL' wFł-dŁQÐ ôUŠ WÝ«-oe X¹dł√ ∫WO−NM*« e¹eFÃ« b³Ž pK*« WM¹bÄ w Â2016 Ë Â1999 wÄUŽ 5Ð TGA ? Ð rNBO Að fM'«Ë dLFÃ« jÐ«u{ b¹b%-AEW¹oeuF Ã« WOÐdFÃ« WJKL*« ¨ ÷U¹dÃ« ¨WO³DÃ« qL(« ÍdJÝË »-UÁ_« Ã«Ë" pÃ-w U0 ¨dD)« qÄ«uŽ XFLł AEWIÐUD²*«-AE UNÄ_« R UJðË s¹bÃ«uÃ« dLŽË WOIK)« VKIÃ« ÷«dÄ_ wKzUFÃ« a¹-U²Ã«Ë AETGA d¹uDð vKŽ dD)« qÄ«uŽ-UŁ¬ qOK×²Ã-«b×½ô« Ã-u/ Â«b ²Ý« w Èd³JÃ« 5¹«dAÃ« q¹b³ð lÄ v{dÄ 206 tŽuL−Ä UMK−Ý ∫ZzU²MÃ« WDO Ð TGA vÃ≈ …dO³JÃ« 5¹«dAÃ« q¹b³ð ôUŠ rO Ið-AEWÝ«-bÃ«-¨WÝË-b*« ôU(« w AE446 …-U² *« WO×BÃ« jÐ«uCÃ« X½UÂ AE…bIFÄË w qL(« ÍdJÝ hO Að-Ë ¨ ôU(« sÄ ©46%® 95 w WÐ«dÁ vKŽ-u¦FÃ« sÄ bÂRÄ wKzUŽ a¹-Uð UN¹bÃ ©17%® 35Ë ¨ UNÄ_« sÄ ©17.5%® 36 ¨jÐ«uCÃUÐ ôU×KÃ dD)« qÄ«uŽ W½-UIÄ X9 UÄbMŽ AE WOIK)« VKIÃ« ÷«dÄ√ sÄ dO³Â qJAÐ b¹eð R UJ²Ã«Ë ¨Â_« dLŽË ¨qL(« ÍdJÝË ¨WÐ«dIÃ« Ê√ błË AETGA ÀËbŠ U0 …dO³JÃ« 5¹«dAÃ« q¹b³ð-uD²Ã …dO³Â dDš qÄ«uŽ UM²Ý«-oe dNþ« ∫W ö)« wKzUFÃ« a¹-U²Ã«Ë ¨qL(« ÍdJÝË ¨vÃË_« Wł-bÃ« sÄ »-UÁ_« Ã«Ë" pÃ-w sÄ qÄ«uFÃ« Ác¼ oe«" AER UJ²Ã«Ë Â_« dLŽ …oeU¹"Ë ¨WOIK)« WO³KIÃ« U¼uA²KÃ AEqÁ_« vKŽ 5HF{-«bI0 dD)« Objectives: To assess potential risk factors and their effect on the development of transposition of the great arteries (TGA). Methods: A retrospective case-control study of all patients diagnosed with TGA between 1999 to 2016 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Age and gender-matched controls were selected. Risk factors, including consanguinity, gestational diabetes, family history of congenital heart disease, parental age, and maternal parity, were collected. Regression modeling was used to analyze the effects of risk factors on the development of TGA. Results: A total of 206 patients with transposition of the great arteries were enrolled in the study. Transposition of the great arteries cases were divided into simple and complex TGA. Selected healthy Original Article controls were 446. In the studied cases, consanguinity was found in 95 (46%) of cases, gestational diabetes was diagnosed in 36 (17.5%) mothers, and 35 (17%) had a confirmed family history of congenital heart disease. When risk factors of the cases were compared to the controls, consanguinity, gestational diabetes, maternal age, and parity were found to significantly increase the incidence of TGA. Conclusion: Our study revealed significant risk factors for the development of transposition of great arteries including first degree consanguineous marriages, gestational diabetes, family history of congenital cardiac anomalies, and increasing maternal age and parity. These factors increased the risk by at least 2 folds.

show abstract

Section: Discussionmentioning

confidence: 99%