“…The resulting mixture was heated under reflux for (6 hours).The resultant mixture was concentrated , and carefully acidified with hydrochloric acid HCl(10%) to give pale yellow precipitate. The crude product was filtered and washed with cold water, recrystallized from ethanol to give the desired product5-Amino-1,3,4thiadiazole-2-thiol (A1) as White needles (7,8), yield (81%),m.p (9).233-235C.A mixture(A1) (0.02mol, 2gm) and Ethyl acetate (0.02mol, 2ml) dissolved in ethanol (50ml) was refluxed on a water bath for(3) hrs, .The resultant mixture[ligand] was concentrated and the Yellow solid which separated was filtered and recrystallised from ethanol. Yield: (86 %), m. p.…”
Syntheses, Characterization and biological Activity of a new ligand [N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)acetamide with some transition metal complexes weam .A
“…The resulting mixture was heated under reflux for (6 hours).The resultant mixture was concentrated , and carefully acidified with hydrochloric acid HCl(10%) to give pale yellow precipitate. The crude product was filtered and washed with cold water, recrystallized from ethanol to give the desired product5-Amino-1,3,4thiadiazole-2-thiol (A1) as White needles (7,8), yield (81%),m.p (9).233-235C.A mixture(A1) (0.02mol, 2gm) and Ethyl acetate (0.02mol, 2ml) dissolved in ethanol (50ml) was refluxed on a water bath for(3) hrs, .The resultant mixture[ligand] was concentrated and the Yellow solid which separated was filtered and recrystallised from ethanol. Yield: (86 %), m. p.…”
Syntheses, Characterization and biological Activity of a new ligand [N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)acetamide with some transition metal complexes weam .A
“…The resulting mixture was heated under reflux for (6 hours).The resultant mixture was concentrated , and carefully acidified with hydrochloric acid HCl(10%) to give pale yellow precipitate. The crude product was filtered and washed with cold water, recrystallized from ethanol to give the desired product5-Amino-1,3,4thiadiazole-2-thiol (A1) as White needles (7,8), yield (81%),m.p (9).233-235C.A mixture(A1) (0.02mol, 2gm) and Ethyl acetate (0.02mol, 2ml) dissolved in ethanol (50ml) was refluxed on a water bath for(3) hrs, .The resultant mixture[ligand] was concentrated and the Yellow solid which separated was filtered and recrystallised from ethanol. Yield: (86 %), m. p.…”
A-new series of transition metal (Cr(III),Fe(III), Co(II) , Ni(II)and Cu(II) ) complexes of ligand [N-(5-sulfonyl-1,3,4,thiadiazol-2-yl)acetamide were synthesized. All the synthesized complexes were characterized by analytical techniques, magnetic susceptibility measurements, elemental analyses, conductance, IR , 1HNMR and mass spectra. The electrolytic behavior were confirmed from their conductance data . It may be concluded that the ligand coordinate through Nitrogen and sulfur atoms as shown in figure (6). for all complexes. The ligand acts as a didentate ligand coordinating through the sulfur[S6] and the nitrogen atom of shiff base [N5]. This view is further supported by the appearance of a band corresponding to the metal–nitrogen stretching vibration at( 547–563) cm–1 in the complexes. From results it was suggested tetrahedral geometry for Ni(II) and Cu(II) complexes, while Cr(III),Fe(III) and Co (III)complexes were assigned octahedral geometrics. All complexes and their parent organic moiety have been screened for antibacterial by using spread method and measurement inhibition zone by using (DMSO). this study showed positivity results, by comparison of inhibition zone with E-coli and staph aurens.
“…Characteristic compounds include sesquiterpenoids,1–4 diterpenoids,5 and triterpenoids6 derivatives. Verbesina virginica L. (white crownbeard) is one of 18 species of Verbesina distributed in the North American continent that has been used ethnobotanically as a gastrointestinal and urinary aid, as well as for antirheumatic, emetic, and laxative, and ceremonial purposes 7.…”
Verbesinosides A–F (1–6), six new 15,27-cyclooleanane-type triterpenoid saponins carrying different aromatic acyl moieties on the aglycon, were isolated from the leaves and flowers of Verbesina virginica. Their structures were established by interpretation of spectroscopic data and chemical methods. The representative major saponin, verbesinoside A, (1) has the structure, 21-trimethoxybenzoyl 15α,27-cycloolean-12-en-3β,21β-diol-28-oic acid 3-O-β-D-xylopyranosyl(1→4)-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside. This is the first report of triterpenoid saponins possessing the unique 15,27-cyclooleanane skeleton. The anisotropic effects of the aromatic acyl moieties to the triterpenoid skeleton are discussed.
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