Congenital Granular Cell Epulis

Conrad, Robert; Perez, Mia

doi:10.5858/arpa.2012-0306-rs

Cited by 56 publications

(88 citation statements)

References 9 publications

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“…[5] The tumor is limited to the soft tissue and does not involve deeper tissues such as bone and teeth. [6] It is important to mention that CGCT does not involve or damage the dentition. Reported dentition damage seems to be an iatrogenic damage related to the surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…[12] Because of the location, potential size of the tumor, and risk of interference with breathing and feeding, complete surgical excision is the treatment of choice. [6][7][8] Recurrence rarely occurs, and the prognosis is reported to be excellent. [13] Spontaneous regression has been reported in isolated few cases and may occur even in case of incomplete resection.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a positive staining result is seen for vimentin and neuron-specific enolase. [6] To achieve an accurate diagnosis, it is essential that all data, both histopathologic and clinical, are thoroughly analyzed. [8] …”

Section: Discussionmentioning

confidence: 99%

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Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

et al. 2018

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Congenital granular cell tumor (CGCT) is an uncommon congenital benign epulis in neonates. A preliminary diagnosis is usually put forth clinically but may be confused with other anomalies. Herein, we report an unusual case of intra-oral congenital granular cell tumor in a 4-day-old female newborn. The tumor was excised completely. At 3-month follow-up, the baby is doing fine without any recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

et al. 2018

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“…Although its higher prevalence in girls suggested hormonal impact, the fact that estrogen and progesteron receptors could not be found on tumor cells confuted this assumption. Although malign forms of other GCTs have been observed, no malignancy related with CE has been reported in the literature so far (2,4). Although spontaneous reduction has been reported in the literature, its treatment generally consists of complete excision of the mass.…”

Section: Discussionmentioning

confidence: 99%

A premature newborn with intraoral tumor

Surmeli-Onay

Api

2015

Turk Arch Ped

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Figure 1. Mass obstructing the mouth space nearly completely 353 Diagnosis: Congenital epulisThe mass which had a short handle, erythematous, punctate minimally hemorrhagic areas and a moderately firm consistency was sent for histopathological examination. On macroscopic examination, a creambrown lesion covered with mucosa with dimensions of 2.5 x 2.1 cm was observed and hemorrhage was observed on the surface. The cross sections were solid, brown and elastic. On microscopic examination, a nodular lesion covered with stratified squamous epithelium with diffuse ulcers on the surface which was characterized with small monotonous poligonal cells with large, granular, eozinophilic cytoplasms was observed. These histopathological findings were compatible with congenital epulis (CE). DiscussionCongenital epulis is a rare, benign soft tissue lesion of the newborn generally originating from the alveolar prominence of the maxilla or mandible. CE which is also called congenital granular cell tumor (GCT) was described by Neumann (1) in 1871 for the first time and hundreds of cases have been reported until the present time. Its characteristic property is that it generally originates from the upper chin and has a single, polypoid structure. However, multiple masses have been reported in 10% of the cases (2). Its etiology has not been elucidated yet. It is observed in girls with a higher rate compared to boys (3). The maxilla/mandible ratio is 3:1 and the female/male ratio is 8:1 or 10:1. Although its higher prevalence in girls suggested hormonal impact, the fact that estrogen and progesteron receptors could not be found on tumor cells confuted this assumption. Although malign forms of other GCTs have been observed, no malignancy related with CE has been reported in the literature so far (2, 4). Although spontaneous reduction has been reported in the literature, its treatment generally consists of complete excision of the mass. No recurrence or metastasis has been reported after surgery. The prognosis is excellent (2, 5, 6).Premature delivery has been reported very rarely in hundreds of patients with congenital epulis in the literature (7,8). The fact that our patient was delivered prematurely is the speciality of our case.Con genital epulis for which the biological origin has not been elucidated yet is histologically observed as cell groups in diffuse layers. These cell groups contain round, intense small nuclei and rough granular cytoplasms. Fine vascular plexus is found between the granular cells. This predisposes to hemorrhage in the lesion (9). It is thought that congenital epulis originates from undifferentiated mesenchymal cells, fibroblasts, myofibroblasts, Schwann cells or odontogenix epithelial cells (10).Congenital epulis causes to problems which require urgent intervention related with respiration and nutrition and severe parental anxiety because of the region of origin. Congenital epulis may render feeding impossible by preventing closure of the mouth and swallowing. This swallowing disorder leads to polyhydramnio...

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“…1 Among its other designations, congenital granular cell myoblastoma, granular cell epulis of infancy, granular cell fibroblastoma come atop. 2 Histologically, the congenital epulis of newborn usually composes of nests of cells with granular cytoplasm set in a scanty to prominent vasculature. Although some cases reported self-involution, the surgical excision is indicated if it grossly interferes with breast feeding.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and management of congenital epulis of new-born: a rare case report and literature review

Ottoman

2015

Int J Sci Rep

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The congenital epulis of new-born is a rare disease of idiopathic etiology and lineage. The literature recorded spontaneous regression of some cases. This finding rendered skeptical questions about its neoplastic nature and posed some speculations about hormonal influences, towards the end of pregnancy, on the growth of the lesion. No malignant potential has been ever reported. Surgery is indicated if the lesion grossly interferes with breast feeding. This paper reports an established diagnosis of congenital epulis of new-born, which was excised surgically with no evidence of recurrence hitherto. Keywords: Congenital epulis, Neonatal lesions, Mucosal swellings, Pediatric oncology

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Congenital Granular Cell Epulis

Cited by 56 publications

References 9 publications

Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

Multiple Congenital Granular Cell Tumor in a Neonate - A Rare Case

A premature newborn with intraoral tumor

Diagnosis and management of congenital epulis of new-born: a rare case report and literature review

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