Congenital dyserythropoietic anemia type I

Woessner, S; Pardo, Patricia López; Lafuente, R; Feliú, Evarist; Vives, Jordi; Sans-Sabrafén, J

doi:10.1007/bf01080264

Cited by 4 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This unusual finding has been reported, however, in a few previous cases [2,5,10). Even if this erythrocyte marker is constantly present in all the cases of type-II CDA (HEMPAS), it is nevertheless not a specific one, since it has been reported in some other erythropaties.…”

Section: Resultsmentioning

confidence: 59%

Congenital Dyserythropoietic Anemia Type I: Report of a Pair of Siblings

Favareto

Schenone

et al. 1986

Acta Haematol

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 59%

Congenital Dyserythropoietic Anemia Type I: Report of a Pair of Siblings

Favareto

Schenone

et al. 1986

Acta Haematol

View full text Add to dashboard Cite

show abstract

Dyserythropoiesis in iron‐deficiency anemia: Ultrastructural reassessment

et al. 1992

View full text Add to dashboard Cite

Iron deficiency is usually included among the causes of acquired dyserythropoiesis. This concept was derived mainly from light microscopic studies. To reassess such a notion at ultrastructural level, a transmission electron microscopic evaluation of bone marrow was performed in seven patients with iron-deficiency anemia. In contrast to the widely accepted concept, derived from light microscopic studies, only a small proportion (2-4%, not different from controls) of erythroblasts displayed some of the features of nuclear dyserythropoiesis. On the contrary, when examining the cytoplasm, we found a significantly increased number of void ropheocytotic vesicles in the majority of late erythroblasts as compared to controls (P less than 0.001). This feature may be considered as an ultrastructural marker of iron deficiency and is consistent with the present knowledge on transferrin-mediated delivery of iron to the cell.

show abstract

Congenital dyserythropoietic anemia type I: A freeze-fracture and thin section electron microscopic study

Hiraoka

Kanayama

Yonezawa

et al. 1983

Blut

View full text Add to dashboard Cite

Congenital dyserythropoietic anemia type I was diagnosed in a Japanese patient. Electron microscopic examination of thin sections revealed the features of erythroblasts peculiar to CDA type I; namely "spongy appearance" of nucleus and "internuclear chromatin bridge" etc. However, the widening of nuclear pores, which has been reported as another peculiar feature of CDA type I erythroblasts, were not confirmed. Aberrations of erythroblast nuclear membrane which have not been hitherto noticed were as follows: The nuclear envelopes of erythroblasts frequently lacked heterochromatin application in wide areas where they often showed a marked invagination or evagination. This is associated with the invasion of cytoplasmic organelles into the nuclear territory and occasionally with the extrusion of the nucleolus into the cytoplasm. There were no nuclear pores on the invaginated or the evaginated portions of the nuclear envelope where the perinuclear cistern was compressed to lose the cisternal space, or widened to contain some membrane debris. The findings with thin sectionings were confirmed with freeze-fracturing. Both findings suggest that an aberration may reside in the erythroblast nuclear membrane itself, but not in nuclear pores.

show abstract

Congenital dyserythropoietic anemia type I

Cited by 4 publications

References 8 publications

Congenital Dyserythropoietic Anemia Type I: Report of a Pair of Siblings

Congenital Dyserythropoietic Anemia Type I: Report of a Pair of Siblings

Dyserythropoiesis in iron‐deficiency anemia: Ultrastructural reassessment

Congenital dyserythropoietic anemia type I: A freeze-fracture and thin section electron microscopic study

Contact Info

Product

Resources

About