Congenital Cystic Disease of the Liver, Pancreas, and Kidney in a Nubian Goat (Capra hircus)

Abstract

A congenital cystic disease of the liver, pancreas, and kidney was diagnosed in a 3-week-old female Nubian goat (Cupru hircus). Gross and histologic features were similar to autosomal recessive polycystic kidney disease in humans and to previous reports of juvenile polycystic disorders in several animal species. Grossly, the lesions were confined to the liver and pancreas. The liver was severely enlarged and contained multiple fluid-filled cysts of various sizes. There was tortuous ectasia of the extrahepatic bile ducts. In the pancreas, multiple small cysts were disseminated throughout the parenchyma. Histologically, there was cavernous ectasia of the intra-and extrahepatic biliary system. Dilated intrahepatic biliary channels formed a branching and anastomosing pattern throughout the hepatic parenchyma and were often bordered by fibrous connective tissue. The pancreas had dilation of intra-and interlobular ducts. Renal cortical tubules and collecting ducts were ectatic. Congenital polycystic disorder has not been documented previously in the goat.

Congenital Cystic Disease of the Liver and Kidney in a Pygmy Goat

“…The literature contains reports of polycystic disorders in African gazelles, cats, dogs, mice, pigs, and, most recently, a 3.5-week-old Nubian goat. 4,6,8,[10][11][12][13][14] The present case has a clinical and pathologic presentation similar to 1 case described previously in a Nubian goat kid, but, in contrast, there were both gross and histologic lesions in the kidney and liver and the pancreas was unaffected.…”

“…10,11,14 Cystic disease was suspected in four juvenile Nubian goats over a 5-year period in the herd with the documented case, but necropsy examinations were not performed to confirm this suspicion. 8 The goat described in this case report was from a primiparous doe and was born with a twin that died from unknown causes at birth.…”

“…This is in contrast to the previous caprine report where there was grossly detectable involvement of the pancreas and liver and histologic involvement of the pancreas (pancreatic ducts), liver (intrahepatic and extrahepatic bile ducts), and kidney (renal cortical tubules and renal collecting ducts). 8 Although cystic disorders of the liver and kidney are the most common manifestations of the syndrome in most species, pancreatic ductular changes have been reported in humans and pigs with polycystic disease. 12 This cystic disorder in juvenile animals of any species most closely resembles the autosomal recessive polycystic disease complex seen in young children.…”

Polycystic Liver Disease in Senile Chamois (Rupicaprae rupicaprae)

“…As in humans, most cystic hepatic disorders are regarded as a congenital malformation (Krotec et al, 1996;McAloose et al, 1998;Straub et al, 2003) and cystic formations can also be present in the kidneys and pancreas (McKenna and Carpenter, 1980;Krotec et al, 1996;Bosje et al, 1998). In most cases liver cysts do not communicate with the intrahepatic biliary duct system and are filled with water and electrolytes without containing bile acid and bilirubin (Van den Ingh and Rothuizen, 1985).…”

Congenital Polycystic Kidney in a White-Tailed Deer (Odocoileus Virginianus)

“…The autosomal recessive form is rare, often diagnosed in early infancy by massive nephromegaly, and is rapidly progressive. 17 Syndromes resembling both the recessive and dominant forms of human PKD have been recognized in animals including cats, 1,2 where Persian cats appear disproportionately affected, 8 dogs, 9,15 mice, 13 pigs, raccoons, 5 and ruminants such as cattle, 14 goats, 7,10 sheep, 3 and springbok (Antidorcas marsupialis). 6 To the authors' knowledge, PKD has not been reported in any member of the family Cervidae.…”