Congenital cutaneous candidiasis: A rare and unpredictable disease

Jagtap, Sujit; Saple, Pallavi; Dhaliat, Saleha B

doi:10.4103/0019-5154.77564

Cited by 17 publications

(48 citation statements)

References 8 publications

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“…Onychia and paronychia may occur and rarely it may be limited to nails. 7 Scalded or burn-like appearance of skin lesions may herald systemic involvement. 8 Severe involvement of gastrointestinal and respiratory tract can occur due to aspiration of infected amniotic fluid that culminates in candidial septicemia manifesting as bronchopneumonia, meningitis, arthritis, endocarditis with microabscesses in liver, brain, kidneys, or spleen.…”

Section: Discussionmentioning

confidence: 99%

Congenital Candidiasis

2019

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Congenital candidiasis is an extremely rare disease with less than 100 cases being reported in the literature. It presents within six days of life with manifestations ranging from localized skin disease to systemic involvement in the form of respiratory distress, sepsis with hepatosplenomegaly, and death. Intrauterine infection by candida may give rise to this condition and it differs from neonatal candidiasis, which manifests as thrush or diaper dermatitis. We report a neonate who presented with diffuse pustular eruption on erythematous background involving head, face, trunk, and palms at birth. Candida albicans was identified on blood culture and budding yeast cells were seen on 10% potassium hydroxide (KOH) preparation on the pus drained from the pustules. Intravenous fluconazole and topical ketoconazole were given and the condition improved completely in two weeks.

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Section: Discussionmentioning

confidence: 99%

Congenital Candidiasis

2019

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“…[ 9 ] Bullae may occur rarely. [ 10 ] Palmar and plantar pustules are considered as hallmark of the disease, but mucosae and napkin area are spared. [ 11 ] Onychia and paronychia may occur and rarely CC may be limited to nails.…”

Section: Discussionmentioning

confidence: 99%

Congenital candidiasis

Aruna¹,

Seetharam²

2014

Indian Dermatol Online J

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Congenital candidiasis (CC) is a rare disease with less than 100 cases being reported in the literature. It presents within six days of life with manifestations ranging from localized skin disease to systemic involvement in the form of respiratory distress, sepsis, and death. We report a neonate who presented with diffuse pustular eruption on erythematous background involving face, trunk, and palms within 24 h after birth. Candida albicans was identified in 10% potassium hydroxide (KOH) smear and culture from the pustules. Intravenous fluconazole and topical ketoconazole were given and the condition improved completely in two weeks. CC is rare and needs to be differentiated from other conditions presenting with pustular lesions at birth in order to avoid complications. Early diagnosis and prompt treatment of this condition is important as untreated cases carry a mortality rate of 8-40%.

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“…In vitro drug release followed by in vitro antifungal studies dictates the efficacy of AmB emulgel against fungal infection, which is further confirmed by in vivo studies. Thus, it could be concluded that AmB[ 21 22 ] in emulgel system represent an excellent means of delivery of antifungal agent. However, systematic clinical studies are further required to extrapolate its effects on humans.…”

Section: Discussionmentioning

confidence: 99%

Delivery of amphotericin B for effective treatment of Candida albicans induced dermal mycosis in rats via emulgel system: Formulation and evaluation

Ganeshpurkar¹,

Vaishya²,

Jain³

et al. 2014

Indian J Dermatol

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Background:Amphotericin B (AmB) is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. However, the drug has various side- effects. Transdermal approach for the delivery of drug is one of the accepted and convenient modes of drug delivery. Aim: The current work was designed to formulate and to evaluate the AmB emulgel system.Materials and Methods:In the preparation of AmB emulgel, Carbopol 930 was used as a gel in this study. The formulation was evaluated for viscosity, spreadability, drug content, drug release and in vitro and in vivo antifungal testing.Results:AmB emulgel was found to penetrate skin effectively and without any irritation. Further, in vivo studies revealed effective therapeutic potential against Candida albicans induced dermal mycosis. Conclusions: The current work, for the first time, revealed effective delivery of AmB across the skin.

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Congenital cutaneous candidiasis: A rare and unpredictable disease

Cited by 17 publications

References 8 publications

Congenital Candidiasis

Congenital Candidiasis

Congenital candidiasis

Delivery of amphotericin B for effective treatment of Candida albicans induced dermal mycosis in rats via emulgel system: Formulation and evaluation

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