Congenital Cutaneous Candidiasis

Sonnenschein, Harry; Taschdjian, Claire L.; Clark, Daniel H.

doi:10.1001/archpedi.1964.02080060262007

Cited by 25 publications

(11 citation statements)

References 10 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5][6][7] The purpose of this report is to record the fourth known instance of congenital cutaneous candidiasis. Most of these infections are contracted during passage through the vagina and become manifest during the first weeks of life.…”

mentioning

confidence: 99%

Congenital Cutaneous Candidiasis

Rhatigan¹

1968

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

CANDIDA infections of the neonate occur relatively commonly. Most of these infections are contracted during passage through the vagina and become manifest during the first weeks of life. It is rare, however, for candidiasis to be diagnosed at birth and therefore to have developed in utero. Several cases of fatal disseminated congenital candidiasis have been reported.1-4 Only three cases of congenital cutaneous candidiasis have been reported.5-7The purpose of this report is to record the fourth known instance of congenital cutaneous candidiasis. The case recorded here is of a full-term infant with diffuse congenital cutaneous candidiasis whose mother had no known rupture of the amnionic sac before delivery. Report of a CaseThe patient was the product of a full-term pregnancy and normal spontaneous delivery from a gravida 2, para 0, 20-year-old white woman with one first trimester abortion. The mother had been treated throughout the pregnancy for vaginal candidiasis. Vinegar douches controlled the infection until the last month of preg¬ nancy when because of some cervical dilatation douching was discontinued. Following this, the vaginitis became more severe and nystatin sup¬ positories were used. No other infections or complications of the gestation were noted. Re¬ peated checks of the urine for glucose and albumin were negative, and results of a fasting blood glucose test were normal.Labor began spontaneously at home; and when the mother was admitted to the hospital, the ville, Fla 32206. cervix was completely dilated. The membranes were intact but ruptured spontaneously shortly after. The amnionic fluid was considered normal.About one-half hour after admission, a 4,350 gm (9 lb 1 ounce) female infant was delivered. The newborn was active, had a vigorous cry, and soon became pink. It was noted immediately that the infant's skin had numerous discrete yellow vesi¬ cles up to 2 to 3 mm in diameter. These vesicles had a red border about 1 mm in width. The vesicles were present over the face, neck, shoul¬ ders, arms, chest, abdomen, and lower extremi¬ ties. The lesions were numerous, probably numbering about 200, and the only area not involved was the back. Photographs of the infant were not obtained, but the child's appearance was very similar to that depicted in the articles by Sonnenschein et alß'7 and in the article by Jahn and Cherry.6The baby was placed in isolation with the mother. Routine newborn care was instituted and the baby continued to do well. The vesicu¬ lar papules were the only positive physical find¬ ings. In other respects the child was normal. Scrapings and cultures of the lesions were taken. In the scrapings from the vesicles, organisms were not seen. Cultures of this material, however, on Mankowski's chlamydospore agar revealed chlamydospore formation and pseudomycelia. Fermentation reactions were character¬ istic of Candida albicans; that is, glucose and maltose were fermented with acid and gas; sucrose was fermented with acid only; and lac¬ tose was not fermented. Similar organisms were culture...

show abstract

mentioning

confidence: 99%

Congenital Cutaneous Candidiasis

Rhatigan¹

1968

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

show abstract

“…In addition to our patient, at least nine other infants with CCC and nail dystrophy have been previously reported (3)(4)(5)(6)(7)(8)(9)(10)(11). Six of the 10 patients were born at 26-37 weeks.…”

Section: Discussionmentioning

confidence: 61%

“…Nail lesions were first noted at birth in one patient (3), but others were noted to develop nail changes at 2–6 weeks of age. In the first case description of CCC with nail dystrophy, 10 nails had “thickened and discolored” changes (3), while others have been noted to be “pitted” (5) and “roughened, opaque, and slightly raised” (7,9). In one patient, the only manifestation of CCC was nail dystrophy (7).…”

Section: Discussionmentioning

confidence: 99%

Nail Dystrophy in Congenital Cutaneous Candidiasis

Clegg

Prose

Greenberg

2003

Pediatric Dermatology

View full text Add to dashboard Cite

Congenital cutaneous candidiasis (CCC) is usually a benign condition characterized by various skin manifestations and is rarely associated with nail changes. We report a premature infant with CCC who developed dystrophy of all 20 nails at about 1 month of age. Nail dystrophy due to Candida albicans in the young infant may be differentiated from other congenital or hereditary nail malformations by appearance, recovery of the organism in nail culture, and complete resolution over a period of several months.

show abstract

“…8 As in the current case, invasion of the interstitium of the lungs or lumen of the bowel may occur in severe infections, with dissemination of disease. Neonatal outcome remains dependent on gestational age and birth weight.…”

Section: Commentmentioning

confidence: 65%