Nail Dystrophy in Congenital Cutaneous Candidiasis

Abstract

Congenital cutaneous candidiasis (CCC) is usually a benign condition characterized by various skin manifestations and is rarely associated with nail changes. We report a premature infant with CCC who developed dystrophy of all 20 nails at about 1 month of age. Nail dystrophy due to Candida albicans in the young infant may be differentiated from other congenital or hereditary nail malformations by appearance, recovery of the organism in nail culture, and complete resolution over a period of several months.

Twenty nail dystrophy in vitiligo

“…The pathogenesis of TND has not been fully elucidated and a nail matrix biopsy is required to delineate the underlying pathology. Lichenoid, spongiotic and psoriatic changes have been reported in various histopathological studies with the spongiotic change being the most common finding 9,10 . Wilkinson et al.…”

“…Lichenoid, spongiotic and psoriatic changes have been reported in various histopathological studies with the spongiotic change being the most common finding. 9,10 Wilkinson et al 13 and Jerasutus et al 14 also revealed spongiotic inflammation in the nail matrix and suggested TND to be a manifestation of endogenous dermatitis with a predilection for the nail matrix. The strong association with dermatoses which have an autoimmune etiopathogenesis, has led some to speculate that the nail changes are primarily due to an autoimmune process.…”

“…It has also been shown to be a manifestation of various dermatoses such as lichen planus, alopecia areata, atopic dermatitis and psoriasis vulgaris 8 . Rarely, it has been linked with ichthyosis vulgaris, incontinentia pigmenti, cutaneous T cell lymphoma, pemphigus, primary biliary cirrhosis, immunoglobulin (Ig)A deficiency, congenital cutaneous candidiasis and vitiligo 9,10,11,12 …”

“…8 Rarely, it has been linked with ichthyosis vulgaris, incontinentia pigmenti, cutaneous T cell lymphoma, pemphigus, primary biliary cirrhosis, immunoglobulin (Ig)A deficiency, congenital cutaneous candidiasis and vitiligo. 9,10,11,12 The pathogenesis of TND has not been fully elucidated and a nail matrix biopsy is required to delineate the underlying pathology. Lichenoid, spongiotic and psoriatic changes have been reported in various histopathological studies with the spongiotic change being the most common finding.…”

Bullous Dermatoses in Childhood: Part I

“…Desquamation usually occurs within 1 to 2 weeks of onset. Congenital cutaneous candidiasis is generally a benign condition, but it may be associated with disseminated infection, especially in premature infants 39 . Patients with congenital or acquired defects in cell‐mediated immunity (T cells, particularly CD 4 ) are susceptible to mucocutaneous forms 40 …”