Congenital Cranio-Orbital Myofibroma

Abstract

A 1-day-old female newborn presenting with a severe left proptosis was found, on imaging, to have a cranial mass extending in both orbits and ethmoid sinuses. Tumor debulking and biopsy were performed through a lateral orbitotomy. Based on histologic findings, a diagnosis of infantile myofibroma was made. No involvement was found in other areas of the body. The patient died because of respiratory arrest after intracranial surgery that was performed 45 days after the orbital surgery. To the authors' knowledge, only one similar case of cranio-orbital myofibroma has been reported previously. This tumor should be considered in the differential diagnosis of congenital proptosis and cranio-orbital tumor. In such cases, tumor debulking can be performed through orbitotomy.

A rare erosive orbital mass in a child: Case report of myofibroma

“…From clinical, imaging, and histopathological perspectives, the current case was similar to other reported cases. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 It appeared to be among rare cases in terms of location in the superolateral orbital area 1 , 2 , 3 , 4 , 5 and had similar extents of soft tissue and bone involvement. Other cases predominantly involved either bone (interosseous) or soft tissue (no bone erosion).…”

“…There is also a rare chance for the tumor to extend to adjacent orbital structures, like extraocular muscles, 7 lacrimal gland and sinuses, or even the cranium. 11 …”

Solitary adult orbital myofibroma: Report of a case and review of the literature

“…The head and neck is the most common anatomic sub-region involved by myofibroma and the tumor is mainly seen in infancy and childhood. There are several case reports and series of infantile/childhood orbital myofibroma 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 and involvement of periocular soft tissues. 20 , 21 , 22 However, though myofibroma is the most common fibrous tumor of infancy, the tumor remains rare in the orbit.…”