Congenital Chylothorax in Neonatal Thyrotoxicosis

Ibrahim, Hassan; Asamoah, Alexander; Krouskop, Richard W.; Lewis, David; Webster, Patricia A.; Pramanik, Arun K.

doi:10.1038/sj.jp.7200049

Cited by 16 publications

(7 citation statements)

References 9 publications

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“…Previously, it has been suggested that pleural effusions with a lymphocyte count above 80% confer a better outcome and support the diagnosis of primary fetal hydrothorax . By definition, primary fetal hydrothorax is a diagnosis of exclusion once causes for secondary hydrothorax are ruled out (eg, genetic conditions, immune hydrops, thoracic masses, and infection) and preliminary evaluation of fetal hydrothorax include the ruling out such potential causes …”

Section: Introductionmentioning

confidence: 99%

“…2 By definition, primary fetal hydrothorax is a diagnosis of exclusion once causes for secondary hydrothorax are ruled out (eg, genetic conditions, immune hydrops, thoracic masses, and infection) and preliminary evaluation of fetal hydrothorax include the ruling out such potential causes. [3][4][5][6][7][8][9] One of the underlying etiologies that may significantly affect the long-term prognosis is genetic abnormality that is classified as chromosomal (aneuploidy and microdeletion/duplication) or single gene disorders. 10,11 Previous studies have reported a prevalence of 4.5% to 41% for karyotype abnormalities in pregnancies affected by pleural effusion.…”

Section: Introductionmentioning

confidence: 99%

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Fetal pleural effusion: Contemporary methods of genetic evaluation

et al. 2019

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Objective To determine the contribution of chromosomal microarray (CMA) and other advanced genetic tests to the genetic evaluation of fetal pleural effusion (FPE) and to identify parameters that might assist in predicting genetic abnormality. Methods A retrospective study of FPE cases referred between 2013 and 2018 was conducted. Cases that underwent genetic evaluation were divided into two groups, chromosomally normal and genetically abnormal. The types and prevalence of genetic abnormalities were reported. Clinical and sonographic parameters were compared. Univariate and multivariate analyses were performed to determine an association between different parameters and genetic abnormality. Results Sixty‐two cases were included in the study. Forty‐eight cases were genetically assessed (karyotype, CMA, whole exome sequencing, Noonan panel, or a combination). A clinically significant genetic abnormality was detected in 29.17% (14/48) of cases. Aneuploidy and single gene disorders were found in 78.6% (11/14) and 21.4% (3/14) of abnormal cases. Four additional cases had microdeletion/duplications detected, yet none were of clinical significance. Multivariate analysis indicated that the presence of anomalies was statistically associated with genetic abnormality (95% CI, 1.144‐168.2; 0.039). Conclusion In our cohort, CMA did not demonstrate an additional clinical yield over karyotyping. The presence of anomalies was independently associated with underlying genetic abnormality.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fetal pleural effusion: Contemporary methods of genetic evaluation

et al. 2019

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“…W konsekwencji przedostawanie się płynów i białka do tkanek skutkuje uogólnionym obrzękiem płodu, który stanowi zagrożenie życia płodu, zwłaszcza jeśli pojawi się przed 24. tygodniem ciąży. Jednak wrodzony chłonkotok opłucnowy jest rzadką przyczyną uogólnionego obrzęku płodu o podłożu nieimmunologicznym -stanowi ok 5% przypadków [11,12,13].…”

Section: Rozwój Układu Chłonnegounclassified

“…Diagnostyka i rozpoznanie wrodzonego chłonkotoku opłucnowego powinno być rozszerzone o badania dodatkowe umożliwiające potwierdzenie bądź wykluczenie obecności w tkankach miękkich i trzewiach malformacji limfatycznych. Wrodzony chłonkotok ponadto obliguje lekarza do poszukiwania cech i objawów zespołów chorobowych, w których istotnym elementem są zaburzenia dotyczące układu chłonnego takich jak zespół Hennekama, zespół Aagenaesa, zespół obrzęk limfatyczny-podwójny rząd rzęs, zespół CLAPO, zespół ODELAID, zespół Turnera [2,11,12].…”

Section: Diagnostyka I Rozpoznanie Chłonkotokuunclassified

“…Oczywiście w przypadkach występowania dużej lub szybko narastającej ilości płynu, konieczne są zabiegi chirurgiczne. W okresie zdrowienia konieczne jest całkowite żywienie pozajelitowe, które zmniejsza produkcję chłonki, lub stosowanie doustnej diety ubogotłuszczowej z suplementacją średniołańcuchowych kwasów tłuszczowych [11,12,13]. Natomiast w przypadkach urazowego uszkodzenia przewodu piersiowego konieczna okazać się może interwencja torakochirurgiczna, a w przypadkach chłonkotoku w przebiegu procesu nowotworowego -radioterapia.…”

Section: Leczenie Chłonkotokuunclassified

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Chłonkotok u pacjentów z wrodzonymi wadami serca w przebiegu leczenia kardiologicznego i kardiochirurgicznego

Romanowicz¹,

Sołtyszewski²,

Haponiuk

et al. 2018

Folia Cardiologica

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StreszczenieChłonkotok jest rzadkim, lecz bardzo poważnym powikłaniem rozległych zabiegów operacyjnych w obrębie klatki piersiowej (operacje wrodzonych wad serca), jak również wrodzonym problemem noworodków, lub konsekwencją procesów rozrostowych w obrębie klatki piersiowej. Przedstawiamy przyczyny chłonkotoku, postępowanie diagnostyczne oraz możliwości terapeutyczne farmakologiczne oraz operacyjne.Słowa kluczowe: chłonkotok, wrodzona wada serca, kardiochirurgia dziecięca Cardiologica 2018; 13, 4: 359-366 Folia

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Long‐term outcome of cases of fetal pleural effusion: A study at a single perinatal center in Japan

Takita

Matsuoka

Goto

et al. 2022

J of Clinical Ultrasound

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Purpose To analyze the long‐term prognosis of primary and secondary fetal pleural effusion (FPE). Methods We investigated all cases of FPE in a single University hospital (2005–2020). Cases were classified as primary (cases with only pleural effusion) and secondary (cases with other abnormalities such as chromosomal abnormalities or fetal cardiac failure). We retrospectively reviewed the medical records from the time of diagnosis, to assess medical procedures performed, chromosomal test results, and clinical outcomes. Results Among 18 027 deliveries, 17 FPEs were identified (primary FPE: 8, secondary FPE: 9). Most primary FPEs were diagnosed in the second trimester of pregnancy, while all secondary FPEs were diagnosed in the third trimester. Secondary FPE was often associated with chromosomal abnormalities, including trisomy 21. The prognosis of pleural effusion caused by trisomy 21 was relatively good, except for cases with TAM. Cases of secondary FPE without trisomy 21 were of cardiac origin, and the neonatal prognosis was poor. The short‐term prognosis was better in the primary FPE group, but long‐term follow‐up identified conditions such as acute encephalitis with refractory, repetitive partial seizures, developmental delay and attention deficit hyperactivity disorder. Conclusion Fetal pleural effusion without the presence of chromosomal abnormalities or morphologies has a good short‐term prognosis, but the long‐term prognosis is poor. Thus, long‐term follow‐up is necessary for all cases of fetal pleural effusion.

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Congenital Chylothorax in Neonatal Thyrotoxicosis

Cited by 16 publications

References 9 publications

Fetal pleural effusion: Contemporary methods of genetic evaluation

Fetal pleural effusion: Contemporary methods of genetic evaluation

Chłonkotok u pacjentów z wrodzonymi wadami serca w przebiegu leczenia kardiologicznego i kardiochirurgicznego

Long‐term outcome of cases of fetal pleural effusion: A study at a single perinatal center in Japan

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