Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital

Wills, Vinitha; Abraham, Jacob; Sreedevi, NS

doi:10.18203/2320-1770.ijrcog20171427

Cited by 4 publications

(6 citation statements)

References 6 publications

(10 reference statements)

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“…This is in agreement with study done by Sarkar et al, and Wills V. 11 et al, where most of the mothers (55.7% and 69.8% respectively) belonged to the age group between 21 and 30 years. 10 Many studies report a very close and significant association of congenital anomalies with advanced maternal age which was in contrast with our study which could be explained by the fact that we included only the absolute numbers and did not include the rest of the mother in these age groups who delivered normal babies. 13,17,18 Only 2% of mothers of neonates with congenital anomalies in this study had multiple pregnancy which indicated an insignificant association.…”

Section: Sga Aga Lgacontrasting

confidence: 89%

“…A study done by Wills V et al, in Kerala showed that 149 mothers gave birth to 151 newborns with congenital anomalies in their study period. 10 Another research by Sarkar S et al, in a tertiary center in East India revealed the incidence to be 2.22%. 11…”

Section: Discussionmentioning

confidence: 96%

“…This was in accordance to a study conducted by Wills V et al, which showed that anomalies related to genitourinary system were most common followed by other system related anomalies. 10 However, many studies reported musculoskeletal anomalies to be most common whereas studies done by Patel KG et al, reported cardiovascular system related anomalies to be most common. 9,11,13,14 Hence the spectrum of malformations varies in different regions.…”

Section: Sga Aga Lgamentioning

confidence: 99%

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Clinical profile of neonates with congenital malformation born at a tertiary teaching hospital in a Himalayan state of India

Daizy

Pradhan

2019

Int J Contemp Pediatr

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Background: Congenital malformations are assuming prominence as a contributor to neonatal and childhood mortality. This study is aimed at identifying the pattern and profile of congenital malformations among neonates delivered in a tertiary teaching hospital in Sikkim which will provide baseline data for future studies.Methods: A hospital based cross sectional observational study was conducted from 15 October 2015 till 15 April 2017 among live newborns delivered in the only teaching hospital of Sikkim. Out of 2521 neonates delivered, 96 neonates met the inclusion criteria. These neonates underwent a detailed clinical evaluation and appropriate investigations. Data collected were entered into Microsoft excel worksheet 2017, SPSS (version 22) was used for data analysis.Results: The occurrence of congenital malformations in the hospital was 3.8%. Neonates with major anomalies were 50% and majority of the anomalies were of genitourinary system (23.96%). The relation between gender and congenital malformation was found to be statistically significant with p value <0.05, predominantly affecting male. Only 6.25% of the malformations were diagnosed prenatally.Conclusions: This study gives data on the pattern and profile of malformation from a geographically isolated place in the Himalayan regions of India which showed some significant variation. It also highlights the lack of adequate facilities for prenatal diagnosis of congenital malformation in these regions.

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Section: Sga Aga Lgacontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Section: Sga Aga Lgamentioning

confidence: 99%

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Clinical profile of neonates with congenital malformation born at a tertiary teaching hospital in a Himalayan state of India

Daizy

Pradhan

2019

Int J Contemp Pediatr

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“…Mode of delivery of congenital fetal anomaly's cases can be seen in figure 3 (29 cases; 48,3%) were born sectio caesarian. The study by Wills also shows that most cases of congenital anomalies were born caesarian (59,1%) and mainly done for obstetric indication (Wills, et al, 2017).…”

Section: Resultsmentioning

confidence: 96%

Clinical Characteristic of Congenital Fetal Anomaly In Tertiary Referral Hospital in East Java, Indonesia

Amani

et al. 2021

IIMJ

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Background: Congenital fetal anomalies were defined as any structural defect present at birth. Congenital fetal anomalies are an important causes of neonatal morbidity and mortality in developed and developing countries that affect health care system. Reliable data on these congenital anomalies are still lacking, especially in Indonesia. Objective: This study aims to determine the characteristic profile of congenital fetal anomaly in single tertiary hospital in East Java, Indonesia. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January – December 2017. Results: There were 58 cases (4,3%) with fetal congenital anomaly from 1360 deliveries in 2017. The majority of cases were referral cases (51 cases; 88%) and only seven cases were booked cases in obstetric outpatient dr. Soetomo General Hospital. Most of these congenital fetal anomaly cases ( 25 cases / 43,1%) were born from mother with ages 20 – 30 years old. Most cases (34 cases; 58,64%) were diagnosed first at third trimester (gestational age > 28 weeks). There were 36 cases (62%) had active termination of pregnancy. Thirty eight percent (22 cases) were born at 37-42 weeks and majority were born section caesaria. The three highest proportion of organ systems involved in fetal congenital anomalies were those of abdomen (22 cases; 37,9%); head (20 cases; 34,5%); thorax and muskuloskeletal (each 12 cases; 20,7%). Conclusion: The incidence of congenital fetal anomaly in dr. Soetomo Hospital at 2017 was 4,3%. Omphalocele and CTEV were two most common types of congenital fetal anomaly found. Most cases of congenital fetal anomalies have a poor prognosis, 67% cases born died. Further research about risk factors and comprehensive database are needed on cases of congenital anomaly to establish appropriate prevention and management.

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“…In another study conducted in the middle part of Kerala also showed an increased incidence of urogenital anomalies (28.5%). 32 Gupta et al found the commonest anomaly was nervous system malformations (41.9%). 27 His findings were similar to that of Mashuda et al who noted 29.8% of nervous system malformations in their study.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of congenital anomalies in a tertiary care centre in North Kerala, India

Jayasree¹,

D’Couth²

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Congenital anomalies have emerged as an important cause for neonatal morbidity and mortality. The prevalence as well as pattern of anomaly varies from place to place. Literature search reveals that India has the highest number of children with birth defects. Methods: This is a cohort study conducted in the Department of Obstetrics and Gynecology during the period [2009][2010][2011][2012][2013][2014][2015]. All mothers admitted with congenital structural defects to the fetus diagnosed by imaging and those who delivered anomalous babies were included in this study. The anomalies were classified based on ICD-10 system. Results: There were a total of 911 anomalous babies born during the study period of which 554 were males and 338 were females.19 babies had ambiguous genitalia. Anomalies were more common in multigravidae and in mothers of age group 20-29 years. Maximum number of babies were born between 37-40weeks. Maternal diabetes was associated with increased incidence of anomalies. Most common system involved was urinary system followed by musculoskeletal system. Conclusions: The prevalence of structural anomalies in the present study is 0.84%. Patients with risk factors for anomalies should undergo pre-pregnancy counselling. Routine antenatal anomaly screening with ultrasound before viability should be done for all patients so that early termination of lethal anomalies can be done. Jayasree S et al. Int J Reprod Contracept Obstet Gynecol. 2018 Mar;7(3):864-869 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 7 · Issue 3 Page 865 rate as well as cause of infant mortality. Immunization and use of broad spectrum antibiotics along with improvement in nutritional status have reduced the problem in low and middle income countries also. In this scenario birth defects will begin to emerge as one of the major contributor of infant morbidity and mortality. 7 A large number of congenital malformations are incompatible with life. But children with congenital defects may develop long term disability which can cause a significant impact on individuals, families, healthcare system and societies. Keywords4 40% of pediatric surgery admissions are contributed by structural birth defects.8 As the healthcare facilities improves life expectancy of children with congenital anomalies also increases with all its consequences.The birth prevalence of congenital anomalies in the developing countries is actually underestimated due poor registry, lack of diagnostic techniques and their reliability.9 Like other low and middle income countries, still congenital anomalies are not considered as a major problem in India. But literature search reveals that India has the highest number of children with birth defects. 10About 2.5% neonates at birth are affected by birth defects which accounts for 8-15% of perinatal deaths and 13-16% of neonatal deaths in India. 11,12About 60% of major malformations have no recognized aetiology. They can occur as an inherent genetic condition, poor diet, ...

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Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital

Cited by 4 publications

References 6 publications

Clinical profile of neonates with congenital malformation born at a tertiary teaching hospital in a Himalayan state of India

Clinical profile of neonates with congenital malformation born at a tertiary teaching hospital in a Himalayan state of India

Clinical Characteristic of Congenital Fetal Anomaly In Tertiary Referral Hospital in East Java, Indonesia

Prevalence of congenital anomalies in a tertiary care centre in North Kerala, India

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