Conformational Preferences of DNA Strands from c-MYC Promoter Region

Abstract

It is now well established that the anionic porphyrin, N-methylmesoporphyrin IX (NMM) exhibits binding selectivity for the DNA G-quadruplex (G4) over other DNA secondary structures. Specifically, NMM binds, promotes and stabilizes a K þ -induced mixed-hybrid G4 conformation, and dem-