Conformal static field radiation therapy treatment of early prostate cancer versus non-conformal techniques: A reduction in acute morbidity

Daily-Diary Evaluated Side-Effects of Conformal versus Conventional Prostatic Cancer Radiotherapy Technique

“…The mean numbers of daily stools and diarrhea score (Tables 2, 3) are also in favor of conformal therapy during the acute phase. Soffen et al (22) showed that acute morbidity after 3-D conformal radiotherapy decreased both medication and interruptions of treatment with up to 50% compared with conventional treatment to the prostate. Vijayakuwar et al (31) and Hanks et al (2) noticed less grade 2 acute toxicities for patients treated with conformal radiotherapy compared with those treated with the conventional box technique.…”

“…In an attempt to decrease these problems Henriksson et al (20) in a prospective, controlled, randomized, doubleblind study showed that sucralfate decreased both acute and late intestinal toxicity, in patients treated with radiotherapy where the pelvic area was involved (20,21). Improved planning of external beam radiotherapy has now rapidly emerged by using a CT-based three-dimensional (3-D) planning and conformal beam radiotherapy (7,22). This technique permits better spearing of the surrounding normal tissue and gives a better opportunity to increase tumor dose within a limited area.…”

Conformal Radiotherapy for Prostate Cancer&Longer Duration of Acute Genitourinary Toxicity in Patients with Prior History of Invasive Urological Procedure

“…Only 9.1% of the initially symptomatic patients had signs of toxicity 12 weeks after treatment. Similarly, Soffen et al (14) reported acute symptoms lasting more than one month in 3 26 (11%) patients treated with 3D-CRT. The authors did not distinguish between GI and GU symptoms.…”

Update on the treatment of prostate cancer with external beam irradiation

“…Patients treated with a two-field technique showed a trend towards increased complications compared to patients treated with four fields [25][26][27]. The acute morbidity of 3DCRT was assessed by the number of patients requiring medication for GI or GU symptoms during the course of radiation treatment [28,29]. Table III shows grade 2 and higher rates of GU and GI morbidity for patients stratified by treatment technique and field size.…”