Confirmed clinical Neospora caninum infection in a boxer puppy from Argentina

Basso, Walter; Venturini, Marı́a Cecilia; Bacigalupe, D.; Kienast, Mariana Eva; Unzaga, Juan Manuel; Larsen, Alejandra Edith; Machuca, Mariana Alejandra; Venturini, L.

doi:10.1016/j.vetpar.2005.05.003

Cited by 23 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some antigens of similar size to the antigenic polypeptides detected in this study were also recognized by canine sera in other studies (Bjerkås et al 1994;Schares et al 2001b;Basso et al 2005;Pinheiro et al 2005). Basso et al (2005) reported a case of clinical neosporosis in a 2-monthold Boxer pup that also had a high IFAT antibody titer (1:12,800).…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Immunoanalysis of three litters born to a Doberman bitch infected with Neospora caninum

Heckeroth

Tenter

2006

Parasitol Res

View full text Add to dashboard Cite

Neospora caninum is a tissue cyst-forming coccidium that may cause neuromuscular disorders in dogs. Infected bitches can transmit the parasite to their pups in utero. Vertical transmission may occur after primary infection during pregnancy and in subsequent pregnancies. The reason why only a few pups develop clinical neosporosis is unknown. We obtained sera from a Doberman bitch and its offspring delivered in three litters. The bitch had a titer of 1:640 in an indirect fluorescent antibody test (IFAT). At least three pups of litter A, one pup of litter B, and two pups of litter C were also seropositive for N. caninum. However, clinical neosporosis developed only in one pup of litter C, which had the highest IFAT titer (1:5,120) of all dogs examined. Western blots carried out after one-dimensional and two-dimensional separation of N. caninum tachyzoites revealed that the largest number of antigens was recognized by sera derived from the bitch. The lowest number of antigens was recognized by serum from the pup with clinical neosporosis. However, this pup uniquely recognized a major antigen with a molecular weight of about 17,000. The information collected in this study adds to our knowledge on why some pups develop clinical neosporosis and others do not.

show abstract

Section: Discussionsupporting

confidence: 83%

“…Basso et al (2005) reported a case of clinical neosporosis in a 2-monthold Boxer pup that also had a high IFAT antibody titer (1:12,800). Serum obtained from this Boxer pup recognized three major antigens at 30, 37, and 45 kDa and five minor antigens at 28, 29, 43, 47, and 67 kDa.…”

Section: Discussionmentioning

confidence: 99%

Immunoanalysis of three litters born to a Doberman bitch infected with Neospora caninum

Heckeroth

Tenter

2006

Parasitol Res

View full text Add to dashboard Cite

show abstract

“…DUBEY et al, 1998;KLEIN;MÜLLER, 2001), although IgG titers are generally greater than 1:400 (DUBEY et al, 1998;BASSO et al, 2005). Antibodies against N. caninum have also been observed in dogs without neurological signs.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of antibodies against Neospora caninum and/or Toxoplasma gondii in dogs with neurological signs

Plugge

Montiani‐Ferreira

Richartz

et al. 2011

Rev. Bras. Parasitol. Vet.

View full text Add to dashboard Cite

This study aimed to evaluate occurrences of antibodies against Neospora caninum and Toxoplasma gondii in dogs with neurological signs. Blood samples from 147 dogs were collected: 127 from owned dogs (attended at the Veterinary Teaching Hospital of the Federal University of Paraná (HV-UFPR) and at private veterinary clinics in the city of Curitiba), and 20 from stray dogs found in Curitiba's metropolitan region. The dogs presented one or more of the following neurological signs: seizures, paresis or paralysis, ataxia, behavioral abnormalities, sensory and somatic disorders and chorioretinitis. The samples were analyzed by means of the indirect fluorescent antibody test (IFAT), at a cutoff dilution of 1:50. Out of the 147 samples obtained, 17 (11.56%) were seropositive for N. caninum, 31 (21.08%) for T. gondii and four (2.72%) for both protozoa. Serum titration on the positive animals showed that 54.83% (17/31) and 41.18% (7/17) had titers > 1:200 against T. gondii and N. caninum, respectively. A significant difference in seropositivity for T. gondii (P = 0.021; OR = 2.87; CI = 1.1 > 2.8 > 7.4) was observed between owned dogs (18.11%) and stray dogs (40%). Inclusion of serological tests for neosporosis and toxoplasmosis is recommended in diagnosing neurological diseases in dogs.

show abstract

“…Dogs can serve as intermediate or definitive hosts and vertical as well as horizontal routes of transmission have been proposed . Dogs of any age can be affected by this polysystemic disease, which can cause inflammation of the brain, spinal cord, meninges, nerve radices, muscles, myocardium, liver, lungs, skin, and pancreas , , . As nonsuppurative inflammation and malacia may be present throughout the central nervous system, multifocal lesions affecting the gray and white matter or cerebellar atrophy can be found histologically , .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging Characteristics in Four Dogs With Central Nervous System Neosporosis

Parzefall

Driver

Benigni

et al. 2014

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Confirmed clinical Neospora caninum infection in a boxer puppy from Argentina

Cited by 23 publications

References 10 publications

Immunoanalysis of three litters born to a Doberman bitch infected with Neospora caninum

Immunoanalysis of three litters born to a Doberman bitch infected with Neospora caninum

Occurrence of antibodies against Neospora caninum and/or Toxoplasma gondii in dogs with neurological signs

Magnetic Resonance Imaging Characteristics in Four Dogs With Central Nervous System Neosporosis

Contact Info

Product

Resources

About