Confirmed case of Zika virus congenital infection, Spain, March 2016

Pérez, Sonia Alanya; Tato, Rubén; Cabrera, Jorge Julio; Lopez, A Lopez; Robles, Olga; Paz, Eugenio; Coira, Amparo; Sánchez-Seco, María Paz; Vázquez, Ana; Carballo, Raquel; Quintas, Carlos; Pousa, Anxela

doi:10.2807/1560-7917.es.2016.21.24.30261

Cited by 33 publications

(28 citation statements)

References 17 publications

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“…Two reports contained information on pregnancies in French Polynesia, 22,27 29 in Brazil, and one each in the US, Spain and Finland with exposure outside the countries of birth. 11,13,18 For discussion purposes, these clinical components can be divided into structural and functional components recognizing the overlap between these categories. Structural components include cranial morphology, brain anomalies, ocular anomalies, and congenital contractures.…”

Section: Congenital Zika Syndromementioning

confidence: 99%

“…In the recent case series, most infants with probable congenital ZIKV infection were noted to have craniofacial disproportion (95.8%) and to a lesser degree biparietal depression (83.3%), prominent occiput (75%) and excess nuchal skin (47.9%). 36 Features supportive of the FBDS phenotype scattered through published reports include redundant scalp, 25,34,37,39 occipital prominence and/or overlapping sutures 12,18,20–22,24,25,36 and typical craniofacial appearance with disproportion. 11,25,31,32,38 The FBDS phenotype is also prevalent in ZIKV-related media (http://www.apimages.com/Collection/Landing/Photographer-Felipe-Dana-Brazil-Zika-Birth-Defects/5437af63923a4384a8b27854132305a5).…”

Section: Congenital Zika Syndromementioning

confidence: 99%

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Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians

et al. 2017

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ontracted through the bite of an infected mosquito or through sexual or other modes of transmission, Zika virus (ZIKV) infection can be prenatally passed from mother to fetus. 1 The virus was first identified in the region of the Americas in early 2015, when local transmission was reported in Brazil. 2 Six months later, a notable increase in the number of infants with congenital microcephaly was observed in northeast Brazil. 3,4 Clinical, epidemiologic, and laboratory evidence led investigators to conclude that intrauterine ZIKV infection was a cause of microcephaly and serious brain anomalies. [5][6][7] However, as with other newly recognized teratogens, these features likely represent a portion of a broader spectrum.A comprehensive review of the English literature, identified by searching Medline and EMBASE for Zika from inception through Sep-tember 30, 2016, was done to better characterize the spectrum of anomalies in fetuses and infants with presumed or laboratoryconfirmed ZIKV infection. A constellation of anomalies that is both consistent and unique, called congenital Zika syndrome (CZS), has emerged but specific components and presumed pathogenetic mechanisms previously have not been well-delineated. [8][9][10] Zika virus infection has spread to more than 45 countries in the Americas and 3 US territories, and, most recently, local transmission was confirmed in the continental United States in the state of Florida. 11 Mosquito-borne transmission of ZIKV in other areas of the United States is possible based on the estimated range of its vectors (Aedes aegypti and Aedes albopictus). 12 Recognition of the CZS phenotype by pediatric clinicians will help ensure appropriate and timely evaluation and follow-up of affected infants.IMPORTANCE Zika virus infection can be prenatally passed from a pregnant woman to her fetus. There is sufficient evidence to conclude that intrauterine Zika virus infection is a cause of microcephaly and serious brain anomalies, but the full spectrum of anomalies has not been delineated. To inform pediatric clinicians who may be called on to evaluate and treat affected infants and children, we review the most recent evidence to better characterize congenital Zika syndrome.OBSERVATIONS We reviewed published reports of congenital anomalies occurring in fetuses or infants with presumed or laboratory-confirmed intrauterine Zika virus infection. We conducted a comprehensive search of the English literature using Medline and EMBASE for Zika from inception through September 30, 2016. Congenital anomalies were considered in the context of the presumed pathogenetic mechanism related to the neurotropic properties of the virus. We conclude that congenital Zika syndrome is a recognizable pattern of structural anomalies and functional disabilities secondary to central and, perhaps, peripheral nervous system damage. Although many of the components of this syndrome, such as cognitive, sensory, and motor disabilities, are shared by other congenital infections, there are 5 features that are rarely seen w...

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Section: Congenital Zika Syndromementioning

confidence: 99%

Section: Congenital Zika Syndromementioning

confidence: 99%

Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians

et al. 2017

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“…8 ZIKV RNA has been detected in semen, 9 urine, 10 saliva, 11 cerebrospinal fluid, 12 vaginal or cervical secretions, 13,14 and other body fluids. 15-18 Most transmissions through sexual contact have been from men with symptomatic infection to their female partners.…”

mentioning

confidence: 99%

Persistence of Zika Virus in Body Fluids — Final Report

Paz–Bailey¹,

Rosenberg²,

et al. 2018

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BACKGROUND To estimate the frequency and duration of detectable Zika virus (ZIKV) RNA in human body fluids, we prospectively assessed a cohort of newly infected participants in Puerto Rico. METHODS We evaluated samples obtained from 150 participants (including 55 men) in whom ZIKV RNA was detected on reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay in urine or blood in an enhanced arboviral clinical surveillance site. We collected serum, urine, saliva, semen, and vaginal secretions weekly for the first month and then at 2, 4, and 6 months. All specimens were tested by means of RT-PCR, and serum was tested with the use of anti–ZIKV IgM enzyme-linked immunosorbent assay. Among the participants with ZIKV RNA in any specimen at week 4, biweekly collection continued until all specimens tested negative. We used parametric Weibull regression models to estimate the time until the loss of ZIKV RNA detection in each body fluid and reported the findings in medians and 95th percentiles. RESULTS The medians and 95th percentiles for the time until the loss of ZIKV RNA detection were 14 days (95% confidence interval [CI], 11 to 17) and 54 days (95% CI, 43 to 64), respectively, in serum; 8 days (95% CI, 6 to 10) and 39 days (95% CI, 31 to 47) in urine; and 34 days (95% CI, 28 to 41) and 81 days (95% CI, 64 to 98) in semen. Few participants had detectable ZIKV RNA in saliva or vaginal secretions. CONCLUSIONS The prolonged time until ZIKV RNA clearance in serum in this study may have implications for the diagnosis and prevention of ZIKV infection. Current sexual-prevention guidelines recommend that men use condoms or abstain from sex for 6 months after ZIKV exposure; in 95% of the men in this study, ZIKV RNA was cleared from semen after about 3 months. (Funded by the Centers for Disease Control and Prevention.)

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“…Fetal malformations such as brain microcalcifications and arthrogryposis were also observed in ultrasound scan [53] .…”

Section: Vertical Transmissionmentioning

confidence: 96%

Advances in research on Zika virus

Ali

Wahid

Rafique

et al. 2017

Asian Pacific Journal of Tropical Medicine

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Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence, neurological complications and other teratogenic outcomes as well as pathogenesis.

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Confirmed case of Zika virus congenital infection, Spain, March 2016

Cited by 33 publications

References 17 publications

Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians

Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians

Persistence of Zika Virus in Body Fluids — Final Report

Advances in research on Zika virus

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