Configurational Structure of 1, 3-Indandione Derivatives by<sup>13</sup>C-Nuclear Magnetic Resonance

“…Titration of 1-methylimidazoline-2-thione, a weak organic acid, with NaOH solution with conductometric determination of the equivalence point was described in [82]. This method can be used for routine assays at the quality control stage.…”

Section: Titrimetric and Electrotitrimetric Analysis Methodsmentioning

confidence: 99%

Analysis of thyrostatic heteroaromatic thioamides (review)

Dolinkin

Chernov’yants

2010

Pharm Chem J

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This review discusses methods widely used in pharmaceutical and clinical practice for the identification and assay of the thyrostatic agents imidazoline-2-thione and uracil-2-thiones. Sample preparation stages (solid-phase and liquid extraction from biological materials) are discussed, along with chemical modification of drug molecules. A scheme for a hypothetical model of the inhibitory action of thyrostatic agents on thyroid hormone biosynthesis is presented. The analytical characteristics of individual methods for assaying thyrostatic agents discussed in this review can be used in manufacturing at the quality control stage.

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“…Further reaction of 6 with sodium azide in hot aqueous DMSO according to ref. [22] yielded 7, which was utilized to prepare the saturated compound 8 and the desired unsaturated derivatives 9, 10, and 11. Catalytic hydrogenation of 7 using palladium/charcoal followed by treatment with phthalic anhydride in acetic acid yielded 8.…”

Section: Chemistrymentioning

confidence: 99%

5′-Substituted Thalidomide Analogs as Modulators of TNF-α

Teubert

Zwingenberger²,

Wnendt

et al. 1998

Arch. Pharm. Pharm. Med. Chem.

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The synthesis of 5′‐substituted thalidomide analogs is described. The amino acids 2 necessary to synthesize the target compounds were prepared by Michael reaction. Condensation of 2 with phthalic anhydrides followed by reaction with urea yielded 4 as diastereomeric mixtures. Furthermore glutethimide (5) was brominated by an improved method and the resulting compound 6 was reacted in several steps with sodium azide, hydrogen, and phthalic anhydride to give 8. In a similar manner, 6 was reacted with sodium azide and various phthalic anhydrides to give 9, 10, and 11. All final compounds were tested in vitro for their inhibitory activity on the release of TNF‐α, using stimulated peripheral mononuclear blood cells (PBMCs). Compounds with an additional aromatic substituent in position 5’ of the thalidomide molecule were more active than thalidomide. Compound 11 was able to reduce increased levels of IL‐2 in vitro.

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Configurational Structure of 1, 3-Indandione Derivatives by¹³C-Nuclear Magnetic Resonance

Abstract: 13C-NMR studies of certain 2-acyl-l , 3-indandiones indicate that the preferred tautomeric form is the enol structure and not the triketo structure. and 2-benzoyl-1,3-indandiones are discussed.The I'C-NMR spectral assignment of 2-propionyl Introduction:

Cited by 3 publications

References 1 publication

Solution Structures of Pyrophthalones, I Structure and Conformation of 1,3-Indandionato-2(2-pyridinium)-betaïn — a ¹H/¹³C NMR Approach

Solution Structures of Pyrophthalones, I Structure and Conformation of 1,3-Indandionato-2(2-pyridinium)-betaïn — a ¹H/¹³C NMR Approach

Analysis of thyrostatic heteroaromatic thioamides (review)

5′-Substituted Thalidomide Analogs as Modulators of TNF-α

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Configurational Structure of 1, 3-Indandione Derivatives by13C-Nuclear Magnetic Resonance

Abstract: 13C-NMR studies of certain 2-acyl-l , 3-indandiones indicate that the preferred tautomeric form is the enol structure and not the triketo structure. and 2-benzoyl-1,3-indandiones are discussed.The I'C-NMR spectral assignment of 2-propionyl Introduction:

Cited by 3 publications

References 1 publication

Solution Structures of Pyrophthalones, I Structure and Conformation of 1,3-Indandionato-2(2-pyridinium)-betaïn — a 1H/13C NMR Approach

Solution Structures of Pyrophthalones, I Structure and Conformation of 1,3-Indandionato-2(2-pyridinium)-betaïn — a 1H/13C NMR Approach

Analysis of thyrostatic heteroaromatic thioamides (review)

5′-Substituted Thalidomide Analogs as Modulators of TNF-α

Contact Info

Product

Resources

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Configurational Structure of 1, 3-Indandione Derivatives by¹³C-Nuclear Magnetic Resonance

Solution Structures of Pyrophthalones, I Structure and Conformation of 1,3-Indandionato-2(2-pyridinium)-betaïn — a ¹H/¹³C NMR Approach

Solution Structures of Pyrophthalones, I Structure and Conformation of 1,3-Indandionato-2(2-pyridinium)-betaïn — a ¹H/¹³C NMR Approach