Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Liang, Shuang; Xiao, Xiao; Bai, Lei; Liu, Bin; Yuan, Meng; Ma, Ping’an; Pang, Maolin; Cheng, Ziyong; Lin, Jun

doi:10.1002/adma.202100333

Cited by 228 publications

(200 citation statements)

References 54 publications

(18 reference statements)

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“…Inorganic sonosensitizers such as TiO 2 nanoparticles are extensively used for ECDT‐SDT bimodal anticancer therapy because of their high chemical stability, reduced phototoxicity, and intrinsic horseradish peroxidase (HRP)‐like nanozyme activity to catalyze H 2 O 2 and produce •OH. [ 130 ] Wang et al. developed ultrafine peptide monoxide nanorods (TiO 1+ x NRs) with enhanced sonosensitization and Fenton‐like catalytic activities for ECDT‐SDT bimodal anticancer therapy.…”

Section: Enhanced Chemodynamic Therapy‐based Multimodal Synergistic Therapymentioning

confidence: 99%

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

et al. 2021

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Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective tumor treatment. However, the limited intratumoral Fenton reaction efficiency restricts the therapeutic efficacy of CDT. Recent years have witnessed the impressive development of various strategies to increase the efficiency of intratumoral Fenton reaction. The introduction of these reinforcement strategies can dramatically improve the treatment efficiency of CDT and further promote the development of enhanced CDT (ECDT)‐based multimodal anticancer treatments. In this review, the authors systematically introduce these reinforcement strategies, from their basic working principles, reinforcement mechanisms to their representative clinical applications. Then, ECDT‐based multimodal anticancer therapy is discussed, including how to integrate these emerging Fenton reinforcement strategies for accelerating the development of multimodal anticancer therapy, as well as the synergistic mechanisms of ECDT and other treatment methods. Eventually, future direction and challenges of ECDT and ECDT‐based multimodal synergistic therapies are elaborated, highlighting the key scientific problems and unsolved technical bottlenecks to facilitate clinical translation.

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Section: Enhanced Chemodynamic Therapy‐based Multimodal Synergistic Therapymentioning

confidence: 99%

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

et al. 2021

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“…[175] Sonosensitizers based on SDT can not only generate enormous ROS to induce tumor cells apoptosis but also have better treatment effects on tumors in deep tissue due to their high penetration depth and target specificity. [9,176] TiO 2 NPs are a common sonosensitizer that has exhibited excellent SDT performance to tumor cells under US irradiation. [177] To further improve their stability and biocompatibility, Park's group reported hydrophilized HTiO 2 NPs via loading carboxymethyl dextran on the NPs' surface.…”

Section: Ros-induced Tumor Apoptosismentioning

confidence: 99%

“…[7] Besides, photodynamic therapy (PDT) and sonodynamic therapy (SDT) that employ light and ultrasound sensitive characteristics can also assist and promote ROS generation. [8][9][10]…”

mentioning

confidence: 99%

ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Cao

Xiang

et al. 2021

Adv Funct Materials

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The extensive research into developing new nanomedicines during the past few years has witnessed significant progress in diverse biomedical fields, especially for combating drug resistance in antitumor and antibacterial therapies. Recently, transition-metal-based enzymatic nanoagents (TM-EnzNAs) with catalytic production of reactive oxygen species (ROS) have been designed and intensively explored, which have become powerful nanoplatforms and exciting research frontiers in constructing next-generation nanotherapeutics to combat drug-resistant tumors and bacteria. Here, the focus is on the recent design, fundamental principles, and material chemistries in developing and applications of TM-EnzNAs. At first, the different ROS-producing mechanisms and the key factors to enhance ROS level are carefully concluded, and the analytic methods are systematically summarized. Then, the rationally engineered TM-EnzNAs via different synthetic approaches with high ROS producing efficiencies are comprehensively discussed, especially the catalytic activities, mechanisms, and structure-function relationships. After that, the representative applications of these ROS-catalytic TM-EnzNAs for antitumor and bacterial eradication are summarized in detail. Finally, the primary challenges and future perspectives have also been outlined. It is anticipated new therapeutic insights into combating drug-resistant tumors and bacteria will be provided, and significant new inspiration for designing future enzymatic nanoagents is offered.

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“…Surely, in addition to the above three metals, there are many other transition metals with similar catalytic capabilities, such as Ti, Co, and Mo. Liang et al [ 42 ] constructed a defect-rich Ti-based metal–organic framework (MOF) (D-MOF(Ti)). Benefiting from the components of Ti 3+ ions.…”

Section: Fenton/fenton-like Reaction Catalyzed By Metal-based Nanoparticlesmentioning

confidence: 99%

Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy

et al. 2021

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Chemodynamic therapy (CDT) catalyzed by transition metal and starvation therapy catalyzed by intracellular metabolite oxidases are both classic tumor treatments based on nanocatalysts. CDT monotherapy has limitations including low catalytic efficiency of metal ions and insufficient endogenous hydrogen peroxide (H2O2). Also, single starvation therapy shows limited ability on resisting tumors. The “metal-oxidase” cascade catalytic system is to introduce intracellular metabolite oxidases into the metal-based nanoplatform, which perfectly solves the shortcomings of the above-mentioned monotherapiesIn this system, oxidases can not only consume tumor nutrients to produce a “starvation effect”, but also provide CDT with sufficient H2O2 and a suitable acidic environment, which further promote synergy between CDT and starvation therapy, leading to enhanced antitumor effects. More importantly, the “metal-oxidase” system can be combined with other antitumor therapies (such as photothermal therapy, hypoxia-activated drug therapy, chemotherapy, and immunotherapy) to maximize their antitumor effects. In addition, both metal-based nanoparticles and oxidases can activate tumor immunity through multiple pathways, so the combination of the “metal-oxidase” system with immunotherapy has a powerful synergistic effect. This article firstly introduced the metals which induce CDT and the oxidases which induce starvation therapy and then described the “metal-oxidase” cascade catalytic system in detail. Moreover, we highlight the application of the “metal-oxidase” system in combination with numerous antitumor therapies, especially in combination with immunotherapy, expecting to provide new ideas for tumor treatment.

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Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Cited by 228 publications

References 54 publications

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

ROS‐Catalytic Transition‐Metal‐Based Enzymatic Nanoagents for Tumor and Bacterial Eradication

Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy

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