“…Conferin (10), the 3 0 -methyl ether of 6,7,3 0 ,4 0 -tetrahydroxyiso-avone, is another example of a 5-deoxyisoavone, and a minor constituent of the whole plant of Caragana conferta. 43 The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of 10 (IC 50 ¼ 19.1 AE 0.11 mM), ascribed to ortho-dihydroxy substitution of the A-ring, was superior to that of the control, butylated hydroxyanisole (IC 50 ¼ 44.3 AE 0.09 mM). In other assays, conferin (10) showed moderate inhibition of lipoxygenase compared to baicalein (5,6,7-trihydroxyavone).…”
Section: Isoflavonesmentioning
confidence: 99%
“…In other assays, conferin (10) showed moderate inhibition of lipoxygenase compared to baicalein (5,6,7-trihydroxyavone). 43 Another minor constituent from the whole plant of C. conferta was described as caragin (11), but in a separate publication. 44 An uncommon C-methylated isoavone (12) characterised as the 6-C-methyl derivative of biochanin A (5,7dihydroxy-4 0 -methoxyisoavone) has been obtained from MeOH extracts of the young stems of Millettia pinnata (published under the synonym Derris indica).…”
Section: Isoflavonesmentioning
confidence: 99%
“…65 Both compounds, which derive from 6,8-diprenylbiochanin A and 6,8-diprenylgenistein, respectively, have oxidised prenyl groups at C-8 of the A-ring, a feature that may account for their low cytotoxicity compared to analogues with non-oxidised prenyl substituents. In addition to 13, stem bark extracts of Erythrina poeppigiana yielded 41-44, which are prenylated derivatives either of genistein 7-methyl ether (41, 42) or 2 0 -hydroxygenistein 7-methyl ether (43,44). 46 Three of the latter (42)(43)(44) were evaluated in assays to measure binding affinity for the estrogen receptors ERa and ERb, but were only weakly active compared to 17b-estradiol.…”
Section: Isoflavonesmentioning
confidence: 99%
“…In addition to 13, stem bark extracts of Erythrina poeppigiana yielded 41-44, which are prenylated derivatives either of genistein 7-methyl ether (41, 42) or 2 0 -hydroxygenistein 7-methyl ether (43,44). 46 Three of the latter (42)(43)(44) were evaluated in assays to measure binding affinity for the estrogen receptors ERa and ERb, but were only weakly active compared to 17b-estradiol. 46 The genus Flemingia Roxb.…”
This account describes 275 new isoflavonoids published between 2008 and 2011 as constituents of the Leguminosae, commenting on their source, identification, biological activity, synthesis, and ecological or chemosystematic significance. Applications of hyphenated analytical techniques to the characterisation of Leguminosae isoflavonoids are also reviewed, together with advances in biosynthetic studies. A checklist of new compounds by species is given, and 226 references are cited.
“…Conferin (10), the 3 0 -methyl ether of 6,7,3 0 ,4 0 -tetrahydroxyiso-avone, is another example of a 5-deoxyisoavone, and a minor constituent of the whole plant of Caragana conferta. 43 The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of 10 (IC 50 ¼ 19.1 AE 0.11 mM), ascribed to ortho-dihydroxy substitution of the A-ring, was superior to that of the control, butylated hydroxyanisole (IC 50 ¼ 44.3 AE 0.09 mM). In other assays, conferin (10) showed moderate inhibition of lipoxygenase compared to baicalein (5,6,7-trihydroxyavone).…”
Section: Isoflavonesmentioning
confidence: 99%
“…In other assays, conferin (10) showed moderate inhibition of lipoxygenase compared to baicalein (5,6,7-trihydroxyavone). 43 Another minor constituent from the whole plant of C. conferta was described as caragin (11), but in a separate publication. 44 An uncommon C-methylated isoavone (12) characterised as the 6-C-methyl derivative of biochanin A (5,7dihydroxy-4 0 -methoxyisoavone) has been obtained from MeOH extracts of the young stems of Millettia pinnata (published under the synonym Derris indica).…”
Section: Isoflavonesmentioning
confidence: 99%
“…65 Both compounds, which derive from 6,8-diprenylbiochanin A and 6,8-diprenylgenistein, respectively, have oxidised prenyl groups at C-8 of the A-ring, a feature that may account for their low cytotoxicity compared to analogues with non-oxidised prenyl substituents. In addition to 13, stem bark extracts of Erythrina poeppigiana yielded 41-44, which are prenylated derivatives either of genistein 7-methyl ether (41, 42) or 2 0 -hydroxygenistein 7-methyl ether (43,44). 46 Three of the latter (42)(43)(44) were evaluated in assays to measure binding affinity for the estrogen receptors ERa and ERb, but were only weakly active compared to 17b-estradiol.…”
Section: Isoflavonesmentioning
confidence: 99%
“…In addition to 13, stem bark extracts of Erythrina poeppigiana yielded 41-44, which are prenylated derivatives either of genistein 7-methyl ether (41, 42) or 2 0 -hydroxygenistein 7-methyl ether (43,44). 46 Three of the latter (42)(43)(44) were evaluated in assays to measure binding affinity for the estrogen receptors ERa and ERb, but were only weakly active compared to 17b-estradiol. 46 The genus Flemingia Roxb.…”
This account describes 275 new isoflavonoids published between 2008 and 2011 as constituents of the Leguminosae, commenting on their source, identification, biological activity, synthesis, and ecological or chemosystematic significance. Applications of hyphenated analytical techniques to the characterisation of Leguminosae isoflavonoids are also reviewed, together with advances in biosynthetic studies. A checklist of new compounds by species is given, and 226 references are cited.
“…Therefore, antioxidants are vital inhibitors of lipid peroxidation not only for food protection but also as a defense mechanism of living cells against oxidative damage (Ibrahim et al, 2012). It has been reported that antioxidants prevent the destruction of b-cells and to prevent or inhibit oxidative stress in the human body as well as food products (Khan et al, 2010a). DPPH is a primary spectrophotometric method for evaluation of antioxidant potential of test compounds.…”
The purpose of the current study was to estimate the antioxidant profile of two compounds, diosgenin and santonin, isolated from Polygonatum verticillatum rhizomes. Stable free radical, 2, 2-diphenyl-1-picrylhydrazyl and reducing power assays were employed for this purpose. The results showed profound free radical scavenging effect of both diosgenin and santonin in a concentration-dependent manner. The calculated half maximal inhibitory concentration (IC50) values for both diosgenin and santonin was 65.80 and 50.03 μg/ml, respectively. Similarly, in reducing power assay, diosgenin and santonin exhibited marked quenching effect. The corresponding IC50 values for both the compounds were 62.10 and 46.40 μg/ml, respectively. In conclusion, both the isolated compounds have strong antioxidant potential, which is consistent with the results of the extracts of the plant.
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