Condylomata acuminata in a case of Hailey‐Hailey disease with a novel mutation

Li, Furong; Zhang, Yuexin; Li, Qianxi; Li, Hang; Wang, Mingyue

doi:10.1111/ddg.14299

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…There are some clinical variants in this disease, such as generalized, segmental, vesiculobullous, condylomatous, circinate or annular, lichenoid, and psoriasiform HHD ( Hwang et al, 2003 ; Vilmer and Dehen, 2004 ; Ghosh et al, 2017 ; Plaza et al, 2017 ; Ni et al, 2018 ; Leducq et al, 2020 ; Ting et al, 2021 ). HHD was concomitant with bullous pemphigoid, eczema herpeticum, and human papillomavirus infection in a few cases ( Chan et al, 2007 ; Shah et al, 2020 ; Li et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Case of Hailey–Hailey Disease Mimicking Condyloma Acuminatum and a Novel Splice-Site Mutation of ATP2C1 Gene

Dai

Wang

et al. 2021

Front. Genet.

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Hailey–Hailey disease (HHD) is a rare autosomal-dominant blistering disorder characterized by recurrent vesicular and erosive lesions at intertriginous sites. We described a 24-year-old male who presented with multiple bright red verrucous papules in his mons pubis, bilateral groins, scrotum, perineum, and crissum, clinically resembling condyloma acuminatum. The histopathology showed extensive acantholysis with the characteristic appearance of a dilapidated brick-wall. The mutation analysis revealed a novel splice-site mutation in the ATP2C1 gene. The patient was definitely diagnosed with HHD. The antibacterial treatments resulted in a dramatic improvement. Our findings help to broaden the understanding of clinical manifestations of HHD and improve the clinical diagnosis and treatment of this disease.

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Section: Discussionmentioning

confidence: 99%

Case Report: A Case of Hailey–Hailey Disease Mimicking Condyloma Acuminatum and a Novel Splice-Site Mutation of ATP2C1 Gene

Dai

Wang

et al. 2021

Front. Genet.

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“…Patients with HHD are susceptible to infections owing to skin barrier damage, but few reports exist of HHD concomitant with HPV6, 16 and 39 infections. 4 Since typical cauliflower-like papules and genital involvement were absent, and PDT resulted in negative HPV58 and koilocytosis, it is unclear whether the HPV58 positivity represented transient colonization or subclinical infection in this case. Nevertheless, HPV infection could complicate the course and prognosis of HHD.…”

mentioning

confidence: 83%