Conductive polyurethane/PEGylated graphene oxide composite for 3D-printed nerve guidance conduits

Farzan, Afsoon; Borandeh, Sedigheh; Seppälä, Jukka

doi:10.1016/j.eurpolymj.2022.111068

Cited by 17 publications

(9 citation statements)

References 54 publications

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“…Farzan et al, 177 have put forward the PU/PEGylated graphene composite as a nerve conduit. The incorporation of polyethylene glycol (PEG) molecules on graphene surface was intended to not only improve its dispersion in polymer matrix but also suppress its toxicity toward the living cells and tissues.…”

Section: Polyurethanesmentioning

confidence: 99%

A review on electrically conductive polyurethane nanocomposites: From principle to application

Jafarzadeh,

Farzaneh,

Haddadi‐Asl

et al. 2023

Polymer Composites

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Polyurethanes (PUs) thanks to the occurrence of phase separation and biphasic structure prevail over other polymer matrixes for impregnation of conductive fillers and production of conductive composites. A number of carbonous fillers including carbon black, carbon fiber, carbon nanotube, graphite and its derivatives, and fullerene can be loaded into the PU matrixes to impart electrical conductivity. The properties of the carbonous fillers, the filler/PU interactions, and the method of compositing determine the conductive performance of the composite. It is possible to modulate the properties of the conductive PU composites and employ them for a number of electronic applications including but not limited to the strain sensors, electromagnetic interference shielding materials, supercapacitors, and tissue engineering scaffolds. In the present review, first, the distinctive properties of PU as a matrix of conductive composites have been discussed. Then, various carbon fillers loaded into the PU matrixes and their structural and conductive properties have been debated. Thereafter, the fabrication methods of the conductive composites as well as the influential parameters on the electrical properties of the composites have been reviewed to provide an insight into how fulfill a PU composite with the desired electrical performance. And finally, a number of applications of conductive PU composites have been put forward.Highlights Polyurethanes are very capable matrixes for conductive composites. Carbonous fillers can be loaded into the PU matrixes to impart conductivity. Conductive PU composites are employed for a number of electronic applications. Herein, properties, fillers, and applications of PU composites are reviewed.

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Section: Polyurethanesmentioning

confidence: 99%

A review on electrically conductive polyurethane nanocomposites: From principle to application

Jafarzadeh,

Farzaneh,

Haddadi‐Asl

et al. 2023

Polymer Composites

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“…The morphology acted as an effective direction for axonal stretching which can enhance the adequate connection of the nerve through the NGC. Except for conventional extruding method, SL as a distinguished 3D-printing technique in biomedical engineering can be used to build furrow patterns by sculpturing the tubes themselves [32,125]. It was reported that NGCs with topographical grooves produced by SL considerably increased the directionality of neurite growth [126].…”

Section: D-printed Functional Bioengineered Constructs With Topograph...mentioning

confidence: 99%

3D printing of functional bioengineered constructs for neural regeneration: a review

Zhu

Wei

et al. 2023

Int. J. Extrem. Manuf.

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3D printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models. However, the complexity of nervous tissues poses great challenges to three-dimensional (3D)-printed bioengineered analogues, which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration. In this work, we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs. Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages. We highlight the advanced strategies by integrating topographical, biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration. The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues, bio-electronics interfacing with native nervous system, neural-on-chips as well as brain-like tissue models are demonstrated. The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.

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“…A potential solution to this problem is to combine graphene with other printable materials, such as polymers. Farzan et al have used PEGylated GO to make 3D-printed conductive nerve guidance conduits with precise geometrical features that support cell elongation in a suitable direction [72]. However, the fabrication of graphene-based composite in a complicated shape and larger construction remains a challenge and needs more research.…”

Section: Fabrication Of Scaffoldmentioning

confidence: 99%

Electrical Stimulation-Mediated Differentiation of Neural Cells on Conductive Carbon Nanofiller-Based Scaffold

Kaushik

Khatua

Ghosh

et al. 2022

Biomedical Materials & Devices

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An important strategy in neural tissue engineering involves imparting electrical properties to the regenerative template to encourage cell proliferation and differentiation. Several clinical studies have confirmed that direct or indirect electrical stimulation therapy greatly impacts the treatment of peripheral and central nerve injury. Nerve regeneration can be accelerated by the application of electrical stimulations of different methods and with varying parameters. For a long period, electrical stimulation along with conventional conductive polymers have played an important role in nerve tissue regeneration, due to their conductivity. However, the low biocompatibility of these materials has brought attention toward the need for the alternative of the conductive polymers. Carbon nanofillers (graphene, nanotubes, and their derivatives) have been showing promising results in bioimaging, biosensing, and composites, simultaneously, proving themselves as a prospective biomaterial in neural tissue repair and regeneration due to their excellent electrical and mechanical properties, alongside, biocompatibility. Therefore, carbon nanofiller-based scaffolds synchronized with electrical stimulation may lead to a breakthrough in the treatment of nerve injury. This review article focuses on the influence of the electrical properties of carbon-based material on nerve tissue engineering. In this article, we explicitly focus on the different methods to deliver electrical stimulation and the pathways involved in the differentiation of neuronal cells. Emphasis is given to the analysis of the suitable fabrication strategies of carbon-based neural scaffold and the way its interfaces interact with neurons for promoting neuronal differentiation. Furthermore, this review summarizes the ongoing advancements to augment the conductivity and biological activities (cell adhesion, proliferation, neural differentiation, neurite outgrowth), as well as to reduce the potential toxicity in conductive carbon nanofiller-based scaffolds.

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Conductive polyurethane/PEGylated graphene oxide composite for 3D-printed nerve guidance conduits

Cited by 17 publications

References 54 publications

A review on electrically conductive polyurethane nanocomposites: From principle to application

A review on electrically conductive polyurethane nanocomposites: From principle to application

3D printing of functional bioengineered constructs for neural regeneration: a review

Electrical Stimulation-Mediated Differentiation of Neural Cells on Conductive Carbon Nanofiller-Based Scaffold

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