Conductive PANI patterns on electrospun PCL/gelatin scaffolds modified with bioactive particles for bone tissue engineering

Rajzer, I.; Rom, Monika; Menaszek, E.; Pasierb, P.

doi:10.1016/j.matlet.2014.09.077

Cited by 46 publications

(33 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…64, 132 Additionally, PANI possesses a wide range of electrical conductivity at a very low operational voltage. 132 Like PPY, scaffolds derived from PANI have been also explored as a scaffold material in the possible application of bone, 59, 60 cardiac, 61–63 and skeletal muscle tissue engineering. 133 Thermoset PANI is insoluble in any organic solvents, thus making it impossible to fabricate structures by thermal and solution casting methods once it is polymerized.…”

Section: Conductive Polymers For Nerve Growth Conduitsmentioning

confidence: 99%

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Anderson

Shelke

Manoukian

et al. 2015

Crit Rev Biomed Eng

View full text Add to dashboard Cite

Treatment of large peripheral nerve damages ranges from the use of an autologous nerve graft to a synthetic nerve growth conduit. Biological grafts, in spite of many merits, show several limitations in terms of availability and donor site morbidity, and outcomes are suboptimal due to fascicle mismatch, scarring, and fibrosis. Tissue engineered nerve graft substitutes utilize polymeric conduits in conjunction with cues both chemical and physical, cells alone and or in combination. The chemical and physical cues delivered through polymeric conduits play an important role and drive tissue regeneration. Electrical stimulation (ES) has been applied toward the repair and regeneration of various tissues such as muscle, tendon, nerve, and articular tissue both in laboratory and clinical settings. The underlying mechanisms that regulate cellular activities such as cell adhesion, proliferation, cell migration, protein production, and tissue regeneration following ES is not fully understood. Polymeric constructs that can carry the electrical stimulation along the length of the scaffold have been developed and characterized for possible nerve regeneration applications. We discuss the use of electrically conductive polymers and associated cell interaction, biocompatibility, tissue regeneration, and recent basic research for nerve regeneration. In conclusion, a multifunctional combinatorial device comprised of biomaterial, structural, functional, cellular, and molecular aspects may be the best way forward for effective peripheral nerve regeneration.

show abstract

Section: Conductive Polymers For Nerve Growth Conduitsmentioning

confidence: 99%

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Anderson

Shelke

Manoukian

et al. 2015

Crit Rev Biomed Eng

View full text Add to dashboard Cite

show abstract

“…In addition, the encapsulation of nanomaterials, such as CNTs into the hydrogel was demonstrated to be a suitable method to provide the desired mechanical properties required to efficiently facilitate the integration of Au microelectrodes. [11] Challenges arise when developing a controllable soft robotics system, as electrical components are typically bulky, brittle and fragile, whereas bio-inspired robots have a high elasticity and low elastic modulus. Therefore, flexible Au microelectrodes were designed to deform in line with the bio-inspired soft robot without cracking or disrupting the polymeric layers and to generate pulses for localized electrical stimulation.…”

Section: Introductionmentioning

confidence: 99%

Electrically Driven Microengineered Bioinspired Soft Robots

et al. 2018

View full text Add to dashboard Cite

To create life‐like movements, living muscle actuator technologies have borrowed inspiration from biomimetic concepts in developing bioinspired robots. Here, the development of a bioinspired soft robotics system, with integrated self‐actuating cardiac muscles on a hierarchically structured scaffold with flexible gold microelectrodes is reported. Inspired by the movement of living organisms, a batoid‐fish‐shaped substrate is designed and reported, which is composed of two micropatterned hydrogel layers. The first layer is a poly(ethylene glycol) hydrogel substrate, which provides a mechanically stable structure for the robot, followed by a layer of gelatin methacryloyl embedded with carbon nanotubes, which serves as a cell culture substrate, to create the actuation component for the soft body robot. In addition, flexible Au microelectrodes are embedded into the biomimetic scaffold, which not only enhance the mechanical integrity of the device, but also increase its electrical conductivity. After culturing and maturation of cardiomyocytes on the biomimetic scaffold, they show excellent myofiber organization and provide self‐actuating motions aligned with the direction of the contractile force of the cells. The Au microelectrodes placed below the cell layer further provide localized electrical stimulation and control of the beating behavior of the bioinspired soft robot.

show abstract

“…It was reported that genipin was about 5000∼10,000 times less toxic than glutaraldehyde . Therefore, genipin is widely used to replace glutaraldehyde and formaldehyde as the biological cross‐linking agent for protein , . The extent of cross‐linking between protein and genipin can be high (about 80–86%) even at a low addition (0.67–2 wt %) of genipin .…”

Section: Introductionmentioning

confidence: 99%

“…20 Therefore, genipin is widely used to replace glutaraldehyde and formaldehyde as the biological cross-linking agent for protein. 14,15 , [21][22][23] The extent of cross-linking between protein and genipin can be high (about 80-86%) even at a low addition (0.67-2 wt %) of genipin. 14 The water resistance, mechanical properties, and thermal stability of genipin-fixed protein materials can be significantly enhanced.…”

Section: Introductionmentioning

confidence: 99%

Short‐range and long‐range cross‐linking effects of polygenipin on gelatin‐based composite materials

Liang

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

Genipin is an ideal cross-linking agent in biomedical applications, which can undergo ring-opening polymerization in alkaline condition. The polygenipin can create short-range and long-range intermolecular cross-linking between protein chains. In this article, the polygenipin with different degree of polymerization was successfully prepared and used to fix gelatin composite materials. The short-range and long-range cross-linking effects of polygenipin were systematically studied. The results show that the composite materials present porous structure with tunable pore sizes in the gel state, which can be easily controlled by adjusting the degree of polymerization of polygenipin. Long-range cross-linking can increase the pore size of the gel. However, during the drying process, the composite films cross-linked by polygenipin with higher degree of polymerization shrank to smaller size to create more compact structure, resulting in the improvement of water resistance properties, thermal stability, tensile strength, and darker color for the composite films. It is interesting that the composite films can partly swell to the original gel structure when in contact with water and saturated water vapor. All the composite films have excellent barrier properties against UV light. However, the compatibility of gelatin and polygenipin is reduced when the degree of polymerization of polygenipin increases to a certain extent, which will result in the formation of phase separation structure. The obtained composite films are ideal candidates for food and pharmaceutical packaging materials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2712-2722, 2016.

show abstract

Conductive PANI patterns on electrospun PCL/gelatin scaffolds modified with bioactive particles for bone tissue engineering

Cited by 46 publications

References 16 publications

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Electrically Driven Microengineered Bioinspired Soft Robots

Short‐range and long‐range cross‐linking effects of polygenipin on gelatin‐based composite materials

Contact Info

Product

Resources

About