Conductive double-network hydrogel composed of sodium alginate, polyacrylamide, and reduced graphene oxide

Kim, Byongyeon; Park, Junggeon; Lee, Jae Young

doi:10.1007/s11814-022-1311-0

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…Secondly, the uniformly distributed rGO within the scaffolds forms an excellent electronic pathway, facilitating the transmission of electrical signals. [37,38] Furthermore, the addition of graphene provides the hydrogels with advantageous oxygen radical scavenging and antioxidant properties. [39,40] This hydrogel acts as a bridge of bioelectric field, sealing the wound and turning the "short circuit" at the injured site into a "completed circuit" (Figure 1a).…”

Section: Resultsmentioning

confidence: 99%

From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing

Zhou,

Dai,

Yan

et al. 2024

Adv Healthcare Materials

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The primary challenges posed by oral mucosal diseases are their high incidence and the difficulty in managing symptoms. Inspired by the ability of bioelectricity to activate cells, accelerate metabolism, and enhance immunity, we have developed a conductive polyacrylamide/sodium alginate crosslinked hydrogel composite containing reduced graphene oxide (PAA‐SA@rGO). This composite possesses antibacterial, anti‐inflammatory, and antioxidant properties, serving as a bridge to turn the “short circuit” of the injured site into a “completed circuit”, thereby prompting fibroblasts in proximity to the wound site to secrete growth factors and expedite tissue regeneration. Simultaneously, the PAA‐SA@rGO hydrogel effectively seals wounds to form a barrier, exhibit antibacterial and anti‐inflammatory properties, and prevent foreign bacterial invasion. As the electric field of the wound was rebuilt and repaired by the PAA‐SA@rGO hydrogel, a 5 × 5 mm2 wound in the full‐thickness buccal mucosa of rats can be expeditiously mended within mere 7 days. The theoretical calculations indicate that the PAA‐SA@rGO hydrogel can aggregate and express SOX2, PITX1 and PITX2 at the wound site, which had a promoting effect on rapid wound healing. Importantly, this PAA‐SA@rGO hydrogel has a fast curative effect and only needs to be applied for the first three days, which significantly improves patient satisfaction during treatment.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing

Zhou,

Dai,

Yan

et al. 2024

Adv Healthcare Materials

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“…S5a† presents the XRD profile for R-GO synthesized using hammer's process (GO preparation) and then reduced using hydrothermal synthesis at 180 °C for 20 h. 34 The XRD peaks at 24.28° and 42.54° represent the (022) and (100) planes of R-GO. 35 The broader peak at 2 θ = 24.28° was ascribed to the removal of oxygen-containing functional groups during chemical reduction. Raman spectroscopic analysis of R-GO (Fig.…”

Section: Resultsmentioning

confidence: 99%

Enhancing high-performance supercapattery electrodes: harnessing structural and compositional synergies via phosphorus doping on bimetallic boride for rapid charging

Sivagurunathan,

Kavinkumar,

Seenivasan

et al. 2023

J. Mater. Chem. A

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“…While phantoms can be good alternatives for animal and human testing, as they are lower cost and easier to store [34], they must properly mimic the biomechanical properties of human skin to validate microneedle models. When utilizing hydrogels as skin phantoms, factors, such as crosslinking density, rehydration, and creating double networks, improve the mechanical strength and toughness of the hydrogel [43][44][45][46] and thus phantom performance.…”

Section: Introductionmentioning

confidence: 99%

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

Defelippi,

Kwong,

Appleget

et al. 2024

Applied Mechanics

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A variety of hollow microneedle (HMN) designs has emerged for minimally invasive therapies and monitoring systems. In this study, a design change limiting the indentation depth of the (3D) printed custom microneedle assembly (circular array of five conical frusta with and without a stopper, aspect ratio = 1.875) fabricated using stereolithography has been experimentally validated and modeled in silico. The micro-indentation profiles generated in confined compression on 1 mm ± 0.073 mm alginate films enabled the generation of a Prony series, where displacement ranged from 100 to 250 µm. These constants were used as intrinsic properties simulating experimental ramp/release profiles. Puncture occurred on two distinct hydrogel formulations at the design depth of 150 µm and indentation rate of 0.1 mm/s characterized by a peak force of 3.5 N (H = 31 kPa) and 8.3 N (H = 36.5 kPa), respectively. Experimental and theoretical alignments for peak force trends were obtained when the printing resolution was simulated. Higher puncture force and uniformity inferred by the stopper was confirmed via microscopy and profilometry. Meanwhile, poroviscoelasticity characterization is required to distinguish mass loss vs. redistribution post-indentation through pycnometry. Results from this paper highlight the feasibility of insertion-depth control within the epidermis thickness for the first time in solid HMN literature.

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Conductive double-network hydrogel composed of sodium alginate, polyacrylamide, and reduced graphene oxide

Cited by 6 publications

References 34 publications

From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing

From Short Circuit to Completed Circuit: Conductive Hydrogel Facilitating Oral Wound Healing

Enhancing high-performance supercapattery electrodes: harnessing structural and compositional synergies via phosphorus doping on bimetallic boride for rapid charging

An Integrated Approach to Control the Penetration Depth of 3D-Printed Hollow Microneedles

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