Diabetic wound infection has always been a huge threat
to human’s
healthcare, and most of the existing therapies have reduced efficacy,
drug resistance and toxic side effects. Therefore, there is an urgent
need to develop innovative therapeutic strategies for diabetic wound
management. At present, the intelligence of stimulus-responsive bioactive
hydrogels in diabetic wound healing has received extensive attention.
This intelligence is mainly reflected in the on-demand release of
active substances in response to physical, chemical or biological
stimuli. This paper focuses on the potential of various stimulus-responsive
bioactive hydrogels and their biological applications in diabetic
wound healing, and briefly discusses the factors of slow diabetic
wound healing and the preparation methods of smart bioactive hydrogels.
Finally, the future development of stimulus-responsive bioactive hydrogels
in the further management of diabetic wounds is presented.