Conductive biomaterials in cardiac tissue engineering

Ye, Genlan; Qiu, Xiaozhong

doi:10.21037/biotarget.2017.08.01

Cited by 10 publications

(19 citation statements)

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“…An electroconductive environment can facilitate intercellular communication that is based on ionic conduction and thereby promoting synchronous and efficient contraction in cardiomyocytes. Electrically conductive materials in various forms, such as electrically conductive polymers (polyaniline (PANi), polypyrrole, and polythiophene), carbon nanotubes, and gold and silver nanoparticles, have been incorporated into scaffolds for cardiac tissue engineering . PANi is one of the widely studied conductive polymers, and it offers a facile synthesis, environmental stability, and tunable electrical properties .…”

Section: Introductionmentioning

confidence: 99%

“…Electrically conductive materials in various forms, such as electrically conductive polymers (polyaniline (PANi), polypyrrole, and polythiophene), carbon nanotubes, and gold and silver nanoparticles, have been incorporated into scaffolds for cardiac tissue engineering. [15] PANi is one of the widely studied conductive polymers, and it offers a facile synthesis, environmental stability, and tunable electrical properties. [16] Additionally, its biocompatibility has been shown in vitro, and PANi does not provoke inflammatory responses in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

Roshanbinfar

Vogt

Ruther

et al. 2019

Adv Funct Materials

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Cardiac tissue engineering is a promising strategy to prevent functional deterioration or even to enhance cardiac function upon myocardial infarction. Here, electrospun fiber mats containing different combinations of electrically conductive polyaniline, collagen, and/or hyaluronic acid are assessed regarding material properties and compatibility with cardiomyocyte attachment and function. Microstructure analysis reveals that collagen fiber mats contain a wide range of fiber diameters after crosslinking (from ≈300 nm to ≈5 µm); all other fiber mats contain fibers in the range of ≈120 to ≈300 nm. Fiber mats exhibit comparable electrical conductivity to and greater mechanical properties than the native human myocardium, which is considered beneficial. Cell–matrix interaction analysis utilizing postnatal rat cardiomyocytes reveals that the fiber mats are non‐cytotoxic and permit cell attachment and contraction. Fiber mats containing collagen (9.89%), hyaluronic acid (1.1%), and polyaniline (PANi, 1.34%) exhibit the most favorable properties with longer contraction time, higher contractile amplitude, and lower beating rates. Improved contraction is accompanied by increased connexin 43 expression. Importantly, this fiber mat is a suitable material for human‐induced pluripotent stem cell–derived cardiomyocytes regarding cytotoxicity, cell attachment, and function. Collectively, these data demonstrate that fiber mats made of collagen, hyaluronic acid, and polyaniline are promising materials for cardiac tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

Roshanbinfar

Vogt

Ruther

et al. 2019

Adv Funct Materials

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“…[1][2][3][4][5][6][7][8] Conductive nanocomposite scaffolds are typically fabricated by incorporating electrically conductive nanomaterials, such as gold nanomaterials (GNMs), 2,3 carbon nanotubes (CNTs), 5,9 and reduced grapheme oxide (rGO), 6 within the macroporous matrix of scaffolding biomaterials, including hydrogels or electrospun nanofibers. [10][11][12] The addition of conductive nanomaterials has been argued to facilitate electrical signal propagation within the scaffold via bridging the insulating matrix pore walls, resulting in a biomimetic matrix similar to the native heart extracellular matrix (ECM), leading to enhanced electrical coupling and excitability of cardiomyocytes (CMs). 2,3,5,9 In addition, as a secondary influence, conductive nanocomposite scaffolds have been shown to promote cellular adhesion and retention 2,13,14 as well as expression of cardiac-specific proteins.…”

Section: Introductionmentioning

confidence: 99%

The influence of electrically conductive and non-conductive nanocomposite scaffolds on the maturation and excitability of engineered cardiac tissues

et al. 2019

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“…In the human body, the heart is a strong power pump due to the myocardium that is made up of tightly packed uniaxial cytoarchitecture and electrically conductive Purkinje fibers, which supply an electrical conductive signal through the whole heart [83]. The regeneration of damaged cardiac tissue after myocardial infarction remains challenging due to the lack of electrical property of most of the implanted scaffolds.…”

Section: Application Of Noble Metal Np–hydrogel Composites In Tissmentioning

confidence: 99%

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

2019

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Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. On the other hand, noble metal particles, particularly gold (Au) and silver (Ag) nanoparticles (NPs), can be incorporated into the hydrogel matrix to form NP–hydrogel composite scaffolds with enhanced physical and biological properties. This review aims to highlight the potential of these hybrid materials in tissue engineering applications. Additionally, the main approaches that have been used for the synthesis of NP–hydrogel composites and the possible limitations and challenges associated with the application of these materials are discussed.

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Conductive biomaterials in cardiac tissue engineering

Cited by 10 publications

References 0 publications

Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

Nanofibrous Composite with Tailorable Electrical and Mechanical Properties for Cardiac Tissue Engineering

The influence of electrically conductive and non-conductive nanocomposite scaffolds on the maturation and excitability of engineered cardiac tissues

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

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