Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

Tan, Hui; Teow, Sin-Yeang; Pushpamalar, Janarthanan

doi:10.3390/bioengineering6010017

Cited by 103 publications

(71 citation statements)

References 95 publications

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“…Since the used bioink is a composite material containing 90% hydroxyapatite with the remaining mostly composed of PLGA, the SPIONs may allow for the formation of microcracks, diminished fusion of printed layers, or bulk material instability. This is mainly due to the fact that the SPION-loaded bioink solution is a colloidal matrix and no chemical bonding occurs when preparing the ink [ 35 , 36 ]. It has been also previously reported that the geometry and porosity of 3D printed HB constructs can significantly affect the ultimate mechanical behavior [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration

et al. 2021

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Current strategies for regeneration of large bone fractures yield limited clinical success mainly due to poor integration and healing. Multidisciplinary approaches in design and development of functional tissue engineered scaffolds are required to overcome these translational challenges. Here, a new generation of hyperelastic bone (HB) implants, loaded with superparamagnetic iron oxide nanoparticles (SPIONs), are 3D bioprinted and their regenerative effect on large non-healing bone fractures is studied. Scaffolds are bioprinted with the geometry that closely correspond to that of the bone defect, using an osteoconductive, highly elastic, surgically friendly bioink mainly composed of hydroxyapatite. Incorporation of SPIONs into HB bioink results in enhanced bacteriostatic properties of bone grafts while exhibiting no cytotoxicity. In vitro culture of mouse embryonic cells and human osteoblast-like cells remain viable and functional up to 14 days on printed HB scaffolds. Implantation of damage-specific bioprinted constructs into a rat model of femoral bone defect demonstrates significant regenerative effect over the 2-week time course. While no infection, immune rejection, or fibrotic encapsulation is observed, HB grafts show rapid integration with host tissue, ossification, and growth of new bone. These results suggest a great translational potential for 3D bioprinted HB scaffolds, laden with functional nanoparticles, for hard tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration

et al. 2021

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“…They are also classified according to the type of incorporated nanomaterials, which is the more common type of classification (Sharma et al, 2018;Vashist et al, 2018;Rafieian et al, 2019). Frequently reported nanofillers in NC hydrogels are silica such as nano-clay (Jin et al, 2018) and fumed silica (Kehr et al, 2013), carbon in the form of carbon nanotubes, graphene (Servant et al, 2014) and graphene oxide (GO) (Rasoulzadeh and Namazi, 2017;Tarashi et al, 2019), metal and metal oxide nanoparticles (Tan et al, 2019) such as gold, silver, iron oxide, titanium oxide (TiO 2 ), nanohydroxyapatite, alumina and zirconia, and polymeric nanoparticles such as nano-scaled cellulose (NSC) (Dutta et al, 2019), including cellulose nanofibers, nanocrystals, and nanowhiskers. In general, depending on the surface chemistry of the nanomaterials, they can act as physical or chemical crosslinkers in NC hydrogels.…”

Section: Nc Hydrogelsmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

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Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

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“…The application of technologies based on biomagnetic nanoparticles has allowed the development of methods for the differentiation of human osteoblasts with an external alternating magnetic field. Thus, MNPs are becoming promising tools for a wide range of applications in biomedicine and, in particular, regenerative biomedicine [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Aptamers Increase Biocompatibility and Reduce the Toxicity of Magnetic Nanoparticles Used in Biomedicine

Zamay

Lukyanenko

et al. 2020

Biomedicines

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Aptamer-based approaches are very promising tools in nanomedicine. These small single-stranded DNA or RNA molecules are often used for the effective delivery and increasing biocompatibility of various therapeutic agents. Recently, magnetic nanoparticles (MNPs) have begun to be successfully applied in various fields of biomedicine. The use of MNPs is limited by their potential toxicity, which depends on their biocompatibility. The functionalization of MNPs by ligands increases biocompatibility by changing the charge and shape of MNPs, preventing opsonization, increasing the circulation time of MNPs in the blood, thus shielding iron ions and leading to the accumulation of MNPs only in the necessary organs. Among various ligands, aptamers, which are synthetic analogs of antibodies, turned out to be the most promising for the functionalization of MNPs. This review describes the factors that determine MNPs’ biocompatibility and affect their circulation time in the bloodstream, biodistribution in organs and tissues, and biodegradation. The work also covers the role of the aptamers in increasing MNPs’ biocompatibility and reducing toxicity.

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Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

Cited by 103 publications

References 95 publications

3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration

3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

Aptamers Increase Biocompatibility and Reduce the Toxicity of Magnetic Nanoparticles Used in Biomedicine

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