Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor

Kondoh, Keisuke; Koyama, Hiroyuki; Miyata, Tetsuro; Takato, Tsuyoshi; Hamada, Hirohumi; Shigematsu, Hiroshi

doi:10.1016/j.cardiores.2003.10.003

Cited by 66 publications

(69 citation statements)

References 26 publications

(62 reference statements)

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“…We used a sustained release of bFGF because bFGF shows not only potential for angiogenesis and arteriogenesis, but also synergistic effects with other angiogenic agents such as VEGF, 30 HGF, 24,31 or PDGF-BB. 32 In addition, we have shown that a combination of bFGF and sarpogrelate, a serotonin blocker, 22 or heparin, 23 enhanced collateral vessel flow effectively.…”

Section: Discussionmentioning

confidence: 99%

A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel An Initial Report of the Phase I-IIa Study

Marui

Tabata

Kojima

et al. 2007

Circ J

121

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Section: Discussionmentioning

confidence: 99%

A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel An Initial Report of the Phase I-IIa Study

Marui

Tabata

Kojima

et al. 2007

Circ J

121

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“…There is evidence to suggest that specific functions unique to individual angiogenic factors may exist during distinct phases of angiogenesis. For example, VEGF has been recognized as a primary initiator of new capillary growth while FGF was implicated in the formation of large collaterals or arteriogenesis in later stages of angiogenesis [35][36][37]. It is apparent that establishing a fully functional neovasculature is likely to require temporal and sequential interaction of several major angiogenic factors in a sustained and coordinated manner.…”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model

Shim

Zhang

et al. 2006

J Biomed Sci

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SummaryThis study investigates the long-term angiogenic effects of ANG-1 and VEGF in a swine chronic myocardial ischemia model. Four-weeks after gradual occlusion of the left circumflex coronary artery by ameroid constrictor, animals were injected with recombinant adenoviral vectors carrying either human ANG-1 (n=9), human VEGF 165 (n=10) or empty vector (n=7) into the left ventricle free wall supplied by the constricted artery. Left ventricular perfusion in animals that received AdANG-1 (3.25±0.16 ml/min/g, p<0.05) recovered robustly 4 weeks after gene transfer while ischemia persisted in the AdVEGF (1.09±0.13 ml/min/ g) and empty vector (1.20±0.03 ml/min/g) groups. Microvascular densities in the left ventricles of animals that received AdANG-1 (19.61±1.76/0.572 mm 2 myocardial tissue, p<0.05) and AdVEGF (18.17±1.43/ 0.572 mm 2 myocardial tissue, p<0.05) were significantly higher than animals that received empty vector (13.53±0.92/0.572 mm 2 myocardial tissue) 12 weeks after gene transfer. ANG-1, but not VEGF, contributed to enhanced regional perfusion by increasing arteriolar density (1.9±0.4/0.572 mm 2 myocardial tissue vs. 0.7±0.2/0.572 mm 2 myocardial tissue, p<0.05) of large-sized (50-100 lm) arterioles. These data demonstrate that gene transfer of ANG-1 and VEGF enhances angiogenesis, but ANG-1 promotes sustained improvement of ventricular perfusion that expedites recovery of ischemic myocardium via arteriogenesis.

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“…These studies have shown that FGF-2 accelerates arteriogenesis, 31 and that gene delivery of VEGF combined with FGF-2 has additive and synergistic effects on collateral development. 32 Moreover, FGF receptor-1 and syndecan-4 protein and mRNA are increased during the early phase of collateral development. 33 Inhibition of FGF in this hindlimb ischemia model inhibited monocyte chemoattractant protein-1-stimulated arteriogenesis.…”

Section: Model Of Collateral Growthmentioning

confidence: 99%

Bradycardia Stimulates Vascular Growth During Gradual Coronary Occlusion

Lamping

Zheng

Xing

et al. 2005

ATVB

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Objective-In cultured endothelium, stretch induces release of growth factors that contribute to angiogenesis. We tested the hypothesis that bradycardia, which prolongs ventricular diastolic filling time and volume, promotes collateral vessel growth. Methods and Results-An ameroid occluder was placed on coronary arteries of dogs with normal heart rates (AM) or bradycardia (55 bpm; AMϩBC). A third group had normal heart rates and no ameroid (control [CON]). Four weeks after occluder placement, myocardial blood flow at rest and maximal vasodilation (adenosine) at equivalent heart rates and vascular morphometry of hearts were measured. In AM dogs, conductance (myocardial flow/diastolic pressure) of collateral-dependent myocardium was similar to collateral-independent myocardium during rest but increased to only one third of CON during maximal vasodilation. In contrast, in AMϩBC dogs, conductance was similar in collateral-dependent and -independent regions during maximal vasodilation. Arteriolar length density in collateraldependent myocardium was 80% greater in AMϩBC than AM dogs. Capillary length density in collateral-dependent region of AM dogs was lower than CON but normal in AMϩBC dogs. The angiopoietin receptor Tie-2 increased in collateral-dependent regions of AM and AMϩBC groups, whereas vascular endothelial growth factor increased in collateral-dependent and -independent regions only in AMϩBC dogs. Conclusion-Chronic

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Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor

Cited by 66 publications

References 26 publications

A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel An Initial Report of the Phase I-IIa Study

A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel An Initial Report of the Phase I-IIa Study

Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model

Bradycardia Stimulates Vascular Growth During Gradual Coronary Occlusion

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